Sik2 (salt inducible kinase 2) - Rat Genome Database

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Gene: Sik2 (salt inducible kinase 2) Chinchilla lanigera
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Symbol: Sik2
Name: salt inducible kinase 2
RGD ID: 8765904
Description: ENCODES a protein that exhibits ATP binding (ortholog); magnesium ion binding (ortholog); protein serine kinase activity (ortholog); INVOLVED IN insulin receptor signaling pathway (ortholog); intracellular signal transduction (ortholog); negative regulation of glycolytic process (ortholog); ASSOCIATED WITH ataxia telangiectasia (ortholog); BH4-deficient hyperphenylalaninemia A (ortholog); Carney-Stratakis syndrome (ortholog); FOUND IN cytoplasm (ortholog); endoplasmic reticulum membrane (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: salt-inducible kinase 2; serine/threonine-protein kinase SIK2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,342,032 - 13,457,563 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,342,032 - 13,458,076 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Sik2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541213,342,032 - 13,457,563 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541213,342,032 - 13,458,076 (+)NCBIChiLan1.0ChiLan1.0
SIK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811111,602,449 - 111,730,855 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11111,602,449 - 111,730,855 (+)EnsemblGRCh38hg38GRCh38
GRCh3711111,473,173 - 111,601,579 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3611110,978,380 - 111,102,845 (+)NCBINCBI36Build 36hg18NCBI36
Build 3411110,978,379 - 111,102,840NCBI
Celera11108,626,358 - 108,750,800 (+)NCBICelera
Cytogenetic Map11q23.1NCBI
HuRef11107,397,365 - 107,521,692 (+)NCBIHuRef
CHM1_111111,356,226 - 111,480,689 (+)NCBICHM1_1
T2T-CHM13v2.011111,612,584 - 111,741,007 (+)NCBIT2T-CHM13v2.0
Sik2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39950,800,944 - 50,920,432 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl950,804,101 - 50,920,373 (-)EnsemblGRCm39 Ensembl
GRCm38950,889,644 - 51,009,132 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl950,892,801 - 51,009,073 (-)EnsemblGRCm38mm10GRCm38
MGSCv37950,700,906 - 50,817,178 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36950,645,031 - 50,761,303 (-)NCBIMGSCv36mm8
Celera948,179,153 - 48,295,530 (-)NCBICelera
Cytogenetic Map9A5.3NCBI
cM Map927.75NCBI
Sik2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8860,121,913 - 60,221,707 (-)NCBIGRCr8
mRatBN7.2851,225,543 - 51,325,343 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl851,225,543 - 51,325,415 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.0855,309,005 - 55,408,608 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl855,308,757 - 55,408,464 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0853,905,730 - 54,005,295 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4854,240,307 - 54,337,976 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera850,772,712 - 50,871,786 (-)NCBICelera
Cytogenetic Map8q23NCBI
SIK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v29112,348,699 - 112,477,488 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan111113,440,776 - 113,571,851 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v011106,484,913 - 106,613,711 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.111110,329,237 - 110,453,543 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl11110,329,237 - 110,453,543 (+)Ensemblpanpan1.1panPan2
SIK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1521,354,127 - 21,479,891 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl521,358,902 - 21,479,841 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha521,276,144 - 21,401,711 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0521,382,313 - 21,503,342 (-)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1521,438,206 - 21,563,749 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0521,338,626 - 21,464,410 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0521,387,568 - 21,513,180 (-)NCBIUU_Cfam_GSD_1.0
Sik2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494793,894,634 - 94,013,880 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366122,691,524 - 2,810,981 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366122,691,729 - 2,810,975 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SIK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl939,368,599 - 39,483,515 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1939,368,555 - 39,483,519 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2944,262,713 - 44,269,792 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SIK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11102,944,171 - 103,070,973 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1102,944,281 - 103,068,823 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604322,907,785 - 23,034,098 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Sik2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247846,745,595 - 6,895,747 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247846,728,504 - 6,900,557 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Ensembl Acc Id: ENSCLAT00000019165   ⟹   ENSCLAP00000018980
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541213,342,032 - 13,457,563 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000019166   ⟹   ENSCLAP00000018981
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541213,342,081 - 13,456,854 (+)Ensembl
Ensembl Acc Id: ENSCLAT00000019167   ⟹   ENSCLAP00000018982
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541213,342,081 - 13,455,450 (+)Ensembl
RefSeq Acc Id: XM_005378076   ⟹   XP_005378133
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541213,342,032 - 13,458,076 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005378133 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000018980
  ENSCLAP00000018980.1
  ENSCLAP00000018981.1
  ENSCLAP00000018982.1
RefSeq Acc Id: XP_005378133   ⟸   XM_005378076
- UniProtKB: A0A8C2VXK6 (UniProtKB/TrEMBL),   A0A8C2VSF8 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000018982   ⟸   ENSCLAT00000019167
Ensembl Acc Id: ENSCLAP00000018980   ⟸   ENSCLAT00000019165
Ensembl Acc Id: ENSCLAP00000018981   ⟸   ENSCLAT00000019166
Protein Domains
Protein kinase   UBA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000012999 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019165 ENTREZGENE
  ENSCLAT00000019165.1 UniProtKB/TrEMBL
  ENSCLAT00000019166.1 UniProtKB/TrEMBL
  ENSCLAT00000019167.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ser/Thr_kinase_SIK1/2 UniProtKB/TrEMBL
  SIK UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
NCBI Gene Sik2 ENTREZGENE
PANTHER MAP/MICROTUBULE AFFINITY-REGULATING KINASE UniProtKB/TrEMBL
  NON-SPECIFIC SERINE/THREONINE PROTEIN KINASE UniProtKB/TrEMBL
Pfam Pkinase UniProtKB/TrEMBL
PIRSF Ser/Thr_PK_SNF1-like UniProtKB/TrEMBL
PROSITE PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  UBA UniProtKB/TrEMBL
SMART S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2VSF8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VUC3_CHILA UniProtKB/TrEMBL
  A0A8C2VXK6 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Sik2  salt inducible kinase 2    salt-inducible kinase 2  Symbol and/or name change 5135510 APPROVED