Tyk2 (tyrosine kinase 2) - Rat Genome Database

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Gene: Tyk2 (tyrosine kinase 2) Chinchilla lanigera
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Symbol: Tyk2
Name: tyrosine kinase 2
RGD ID: 8761052
Description: ENCODES a protein that exhibits growth hormone receptor binding (ortholog); non-membrane spanning protein tyrosine kinase activity (ortholog); protein tyrosine kinase activity (ortholog); INVOLVED IN cell population proliferation (ortholog); cell surface receptor signaling pathway via JAK-STAT (ortholog); interleukin-10-mediated signaling pathway (ortholog); PARTICIPATES IN angiotensin II signaling pathway via AT1 receptor; Interleukin-10 signaling pathway; interleukin-12 signaling pathway; ASSOCIATED WITH autistic disorder (ortholog); Cocaine-Related Disorders (ortholog); COVID-19 (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: non-receptor tyrosine-protein kinase TYK2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,617,999 - 1,636,068 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,618,099 - 1,637,996 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytoplasm  (ISO)
nucleus  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tyk2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,617,999 - 1,636,068 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,618,099 - 1,637,996 (-)NCBIChiLan1.0ChiLan1.0
TYK2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,350,533 - 10,380,572 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1910,350,528 - 10,380,608 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,461,209 - 10,491,248 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,322,209 - 10,352,211 (-)NCBINCBI36Build 36hg18NCBI36
Build 341910,322,208 - 10,352,211NCBI
Celera1910,356,496 - 10,385,954 (-)NCBICelera
Cytogenetic Map19p13.2NCBI
HuRef1910,041,213 - 10,071,290 (-)NCBIHuRef
CHM1_11910,461,760 - 10,491,969 (-)NCBICHM1_1
T2T-CHM13v2.01910,476,657 - 10,506,988 (-)NCBIT2T-CHM13v2.0
Tyk2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39921,015,364 - 21,042,689 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl921,015,364 - 21,042,539 (-)EnsemblGRCm39 Ensembl
GRCm38921,104,068 - 21,131,393 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl921,104,068 - 21,131,243 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,908,512 - 20,935,719 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36920,854,476 - 20,881,612 (-)NCBIMGSCv36mm8
Celera918,372,782 - 18,399,989 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.71NCBI
Tyk2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8827,918,054 - 27,943,319 (-)NCBIGRCr8
mRatBN7.2819,641,881 - 19,667,157 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl819,641,884 - 19,667,044 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx823,661,293 - 23,682,384 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0821,959,148 - 21,980,237 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0819,871,547 - 19,892,652 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0822,118,224 - 22,149,807 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl822,124,560 - 22,150,005 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0822,180,760 - 22,205,979 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4820,096,969 - 20,149,004 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1820,128,873 - 20,148,992 (-)NCBI
Celera821,036,299 - 21,057,402 (-)NCBICelera
Cytogenetic Map8q13NCBI
TYK2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22015,268,167 - 15,299,165 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11914,266,820 - 14,297,826 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0199,901,612 - 9,932,623 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11910,565,490 - 10,596,647 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,565,490 - 10,594,541 (-)Ensemblpanpan1.1panPan2
TYK2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,747,145 - 50,770,008 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,748,329 - 50,769,216 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,617,718 - 50,639,776 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02051,269,592 - 51,291,659 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2051,269,646 - 51,291,659 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12050,475,504 - 50,497,770 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02050,904,500 - 50,926,568 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02051,145,386 - 51,167,670 (+)NCBIUU_Cfam_GSD_1.0
Tyk2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,650,169 - 209,673,217 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936659681,310 - 702,962 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936659681,463 - 704,484 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TYK2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl269,157,811 - 69,183,456 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1269,157,774 - 69,183,555 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,492,135 - 69,517,888 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TYK2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,399,945 - 9,420,054 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl69,399,775 - 9,417,630 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607410,583,417 - 10,634,844 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tyk2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,500,339 - 2,517,694 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248282,499,811 - 2,518,817 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000019747   ⟹   ENSCLAP00000019554
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554951,617,999 - 1,636,068 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000019748   ⟹   ENSCLAP00000019555
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554951,617,999 - 1,636,068 (-)Ensembl
RefSeq Acc Id: XM_005405593   ⟹   XP_005405650
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,618,099 - 1,636,993 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505151   ⟹   XP_013360605
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,619,956 - 1,636,993 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505152   ⟹   XP_013360606
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,619,956 - 1,637,820 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505153   ⟹   XP_013360607
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,619,956 - 1,637,996 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505154   ⟹   XP_013360608
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,619,956 - 1,636,718 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505155   ⟹   XP_013360609
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,619,956 - 1,636,987 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505156   ⟹   XP_013360610
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,619,956 - 1,635,550 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505157   ⟹   XP_013360611
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,619,956 - 1,636,993 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505158   ⟹   XP_013360612
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,619,956 - 1,637,017 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505159   ⟹   XP_013360613
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,619,924 - 1,636,993 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005405650   ⟸   XM_005405593
- Peptide Label: isoform X3
- UniProtKB: A0A8C2VRS4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013360613   ⟸   XM_013505159
- Peptide Label: isoform X5
- Sequence:
RefSeq Acc Id: XP_013360607   ⟸   XM_013505153
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013360606   ⟸   XM_013505152
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013360612   ⟸   XM_013505158
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_013360611   ⟸   XM_013505157
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_013360605   ⟸   XM_013505151
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013360609   ⟸   XM_013505155
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013360608   ⟸   XM_013505154
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_013360610   ⟸   XM_013505156
- Peptide Label: isoform X1
- Sequence:
Ensembl Acc Id: ENSCLAP00000019555   ⟸   ENSCLAT00000019748
Ensembl Acc Id: ENSCLAP00000019554   ⟸   ENSCLAT00000019747
Protein Domains
FERM   Protein kinase


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000013417 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000019747.1 UniProtKB/TrEMBL
  ENSCLAT00000019748 ENTREZGENE
  ENSCLAT00000019748.1 UniProtKB/TrEMBL
Gene3D-CATH Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro Band_41_domain UniProtKB/TrEMBL
  FERM_2 UniProtKB/TrEMBL
  FERM_domain UniProtKB/TrEMBL
  FERM_F1 UniProtKB/TrEMBL
  FERM_F2 UniProtKB/TrEMBL
  JAK UniProtKB/TrEMBL
  Jak1_PHL_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser-Thr/Tyr_kinase_cat_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Tyr_kinase_AS UniProtKB/TrEMBL
  Tyr_kinase_cat_dom UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_Jak/Tyk2 UniProtKB/TrEMBL
  Tyr_kinase_non-rcpt_TYK2_N UniProtKB/TrEMBL
NCBI Gene Tyk2 ENTREZGENE
PANTHER NON-RECEPTOR TYROSINE-PROTEIN KINASE TYK2 UniProtKB/TrEMBL
  TYROSINE-PROTEIN KINASE HOPSCOTCH UniProtKB/TrEMBL
Pfam FERM_F1 UniProtKB/TrEMBL
  FERM_F2 UniProtKB/TrEMBL
  Jak1_Phl UniProtKB/TrEMBL
  PK_Tyr_Ser-Thr UniProtKB/TrEMBL
  SH2_1 UniProtKB/TrEMBL
PRINTS JANUSKINASE UniProtKB/TrEMBL
  TYRKINASE UniProtKB/TrEMBL
  YKINASETYK2 UniProtKB/TrEMBL
PROSITE FERM_3 UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_TYR UniProtKB/TrEMBL
SMART B41 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  TyrKc UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF47031 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2VRS4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YS92_CHILA UniProtKB/TrEMBL