Krt6a (keratin 6A) - Rat Genome Database

Name: Krt6a
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Krt6a (keratin 6A) Chinchilla lanigera

Analyze

Symbol:

Krt6a

Name:

keratin 6A

RGD ID:

8752335

Description:

INVOLVED IN antimicrobial humoral immune response mediated by antimicrobial peptide (ortholog); defense response to Gram-positive bacterium (ortholog); intermediate filament organization (ortholog); ASSOCIATED WITH genetic disease (ortholog); pachyonychia congenita (ortholog); Pachyonychia Congenita 3 (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

keratin 6A, type II; keratin, type II cytoskeletal 6A

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	KRT6A (keratin 6A)	NCBI	Ortholog
Mus musculus (house mouse):	Krt6a (keratin 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	KRT6A (keratin 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	LOC486523 (keratin 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Krt6a (keratin 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	KRT6A (keratin 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	LOC103238356 (keratin, type II cytoskeletal 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Krt6a (keratin 6A)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955547	2,902,962 - 2,907,670 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

pachyonychia congenita (ISO)

Pachyonychia Congenita 3 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

antimicrobial humoral immune response mediated by antimicrobial peptide (ISO)

defense response to Gram-positive bacterium (ISO)

intermediate filament organization (ISO)

keratinization (ISO)

morphogenesis of an epithelium (ISO)

negative regulation of entry of bacterium into host cell (ISO)

Wnt signaling pathway (ISO)

wound healing (ISO)

Molecular Function

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species
2.	OMIM Disease Annotation Pipeline	OMIM Disease Annotation Pipeline

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Krt6a
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955547	2,902,962 - 2,907,670 (-)	NCBI	ChiLan1.0	ChiLan1.0

KRT6A
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	52,487,176 - 52,493,257 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	52,487,176 - 52,493,257 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	52,880,960 - 52,887,041 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	51,167,225 - 51,173,448 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	51,167,243 - 51,173,287	NCBI
Celera	12	52,527,198 - 52,533,425 (-)	NCBI		Celera
Cytogenetic Map	12	q13.13	NCBI
HuRef	12	49,924,865 - 49,931,092 (-)	NCBI		HuRef
CHM1_1	12	52,847,818 - 52,854,045 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	12	52,451,772 - 52,457,856 (-)	NCBI		T2T-CHM13v2.0

Krt6a
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	15	101,598,363 - 101,602,746 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	15	101,598,345 - 101,602,742 (-)	Ensembl		GRCm39 Ensembl
GRCm38	15	101,689,928 - 101,694,305 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	15	101,689,910 - 101,694,307 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	15	101,520,359 - 101,524,736 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	15	101,517,962 - 101,522,339 (-)	NCBI		MGSCv36	mm8
Celera	15	103,843,812 - 103,848,189 (-)	NCBI		Celera
Cytogenetic Map	15	F2	NCBI
cM Map	15	56.97	NCBI

KRT6A
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	41,703,387 - 41,709,464 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	41,700,149 - 41,706,227 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	36,270,961 - 36,277,035 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	37,048,390 - 37,054,607 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	37,048,390 - 37,054,607 (+)	Ensembl	panpan1.1		panPan2

LOC486523
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	27	2,609,414 - 2,623,810 (+)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	27	43,630,209 - 43,644,448 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	27	2,607,992 - 2,613,493 (+)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	27	2,625,515 - 2,631,019 (+)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	27	2,610,753 - 2,625,394 (+)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	27	44,028,444 - 44,042,667 (-)	NCBI		UU_Cfam_GSD_1.0

Krt6a
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404945	63,256,954 - 63,261,682 (+)	NCBI		HiC_Itri_2
SpeTri2.0	NW_004936512	9,903,206 - 9,908,009 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

KRT6A
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	5	17,780,928 - 17,868,402 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	5	17,830,147 - 17,851,113 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	5	18,185,925 - 18,188,037 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

LOC103238356
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	48,636,023 - 48,643,854 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	48,636,573 - 48,642,096 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023667010	7 - 5,553 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Krt6a
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624904	631,684 - 639,693 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005411944	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01072301	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01262090	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005411944 ⟹ XP_005412001

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955547	2,902,962 - 2,907,670 (-)	NCBI

Sequence:

show sequence

TCTTTCACTCACCCTTCTCAGCTCTGCTCTCAGCCTCTCACGCCTTCCCAGCCTACTCAGCCCC
AGGAAACATGTCTAGCAAAACCACCGTGAGGACCCAAAGCAGCAGCCGCCGGGGCTTCAGTGCC
AGCTCAGCCAGAGTCCCTGGGCTCAGCCGCTCCGGCTTCAGCAGTGTCTCTGTGTGCCGCTCCA
GGGGCAGTGGCGGCATTGGGGCAGCGTATGGAGGAGCTGGCTTTGGCAGCAGGAGCCTCTATGG
CCTGGGAGGTTCCAAGAGGATCTCCATCGGAGGGGGCAGCTGTGCCATCGGAGGAGGATATGGC
AGCAGAGTTGGAGGTGGCTTTGGCTTTGGAGGCGGAGCCGGCAGTGGATTTGGTTATGGTGGTG
GAGTTGGTAGCGGTTTTGGGCTCGGTGGCGGAGCTGGCTTTGGTGGTGGCTATGGGGGCGCTGG
CTTTCCTGTGTGTCCCCCTGGCGGCATCCAAGAGGTCACCATCAACCAGAGCCTCCTCACTCCT
CTGAACCTGGAAATCGACCCCACCATCCAGCGGGTGAGGACGGAGGAGCGTGAGCAGATCAAGA
CCCTCAACAACAAGTTCGCCTCCTTCATCGACAAGGTGCGCTTCCTGGAGCAACAGAACAAGGT
CCTGGACACCAAGTGGACCCTGCTCCAGGAGCAGGGCACCAAGACAGTCAGGCAGAACCTGGAG
CCTCTGTTTGAGCAGTACATCAACAACCTCAGGAGGCAGCTGGACTCCATCCTTGGAGAGAGAG
GCCGCCTGGACTCAGAGCTGAGGAACATGCAGGACACAGTGGAGGACTACAAGCACAAATATGA
AGATGAAATCAACAAGCGCACAGCAGCAGAGAATGAATTTGTGACCTTGAAAAAGGATGTGGAT
GCTGCCTACATGAACAAGACTGAACTGCAAACCAAGGCAGACAGCCTCATCGATGAGATCAACT
TCCTGAGAACCTTGTATGAGGCCGAGCTGGCTCAGATGCAAACCCACATCTCAGACACTTCTGT
GGTCCTGTCCATGGATAACAACCGCAGCTTGGACCTGGACAGCATCATTGCTGAAGTCAAGGCC
CAGTATGAGGAGATCGCTCAGAGAAGCCGGGCTGAGGCTGAGTCCTGGTACCAGACCAAGTATG
AGGAGCTGCAAGTCACAGCGGGCAGACACGGGGACGACCTGCGCAACACCAAGCAGGAAATCGC
TGAGATCAACCGCATGATCCAGAGGCTGAGATCTGAGATCGACCACGTCAAGAAGCAGTGCACC
AATCTGCAGGCCGCCATCGCTGATGCTGAGCAGCGTGGGGAGCTGGCCCTCAAGGATGCCAGGA
ACAAGCTGGAAGGGCTGGAGGATGCCTTGCAGAAGGCCAAGCAGGACATGGCCAGGCTGCTCAA
GGAGTACCAGGAGCTCATGAATGTCAAACTGGCCTTGGACGTCGAGATCGCCACCTACAGGAAG
CTGCTGGAAGGAGAAGAGTGCAGGCTGAATGGCGAAGGTGTTGGACAGGTCAACATCTCTGTGA
CCCAGTCCACCGTCTCCAGCGGCTATGGCGGTGCCAGCGGCATGGGCGGTGGCGTAGGCCTGGG
GGGAGGCAGCGGCTACTCCTACAGCTCTGGTCACAGCCTTGGAGGTGGCTTCAGTTCTGGCAGT
GGCAGAGGCATCAGCATTGGAGGCGGCCTGAGCTCTGTTGGGGGCAGCACATCCTCCATCAAGT
ACACCAGCTCCTCCTCCAGCAGGAAAAGCTACAAGCACTGAAGTCCTCAGCTCCTGGATAGGTG
CTTGGCCCTCTGGCTACAGAGCTTCTTCTCAGGCCCTCATCCTCCCTTGGCCTCTGCTCTGTAG
TTAGAGCTGAGAATGGGCAAGCCCCTACTTTCACTCTTTGTACCCCTTCTTCCATAGTTGCTGG
CCTTCAGAATCTCAATCTCTGATACAACATTGTGATTTACTCACGTGTAGGTCCTCACCGTATT
GCTCCGTTATCAAGGTCTTACCTGTGTTGTGTTATCACTGAAGTTGAACACTGCAGGGGAATTA
TCTACAACACTTTGCTACCACAAGTCCTTGCTTGAGACTTACTTAAGAACAGGGCAGCTCCCCT
TTGGTCTCAGTTGACCAAACAATACCCCATCTTTCACATGTTGTGAGACTGTCTTGCAGTGACT
GTGATAGCACAAGCCCTTCAGTGTATAGACCTATATCCCTGTGATGCCTTCACTACTCCTTGCT
TTCTTGTAACTTTTAAATAAAGCAAATTTATGATATAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005412001	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000001238
	ENSCLAP00000001238.1

RefSeq Acc Id:

XP_005412001 ⟸ XM_005411944

- UniProtKB:

A0A8C2ULR2 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MSSKTTVRTQSSSRRGFSASSARVPGLSRSGFSSVSVCRSRGSGGIGAAYGGAGFGSRSLYGLG
GSKRISIGGGSCAIGGGYGSRVGGGFGFGGGAGSGFGYGGGVGSGFGLGGGAGFGGGYGGAGFP
VCPPGGIQEVTINQSLLTPLNLEIDPTIQRVRTEEREQIKTLNNKFASFIDKVRFLEQQNKVLD
TKWTLLQEQGTKTVRQNLEPLFEQYINNLRRQLDSILGERGRLDSELRNMQDTVEDYKHKYEDE
INKRTAAENEFVTLKKDVDAAYMNKTELQTKADSLIDEINFLRTLYEAELAQMQTHISDTSVVL
SMDNNRSLDLDSIIAEVKAQYEEIAQRSRAEAESWYQTKYEELQVTAGRHGDDLRNTKQEIAEI
NRMIQRLRSEIDHVKKQCTNLQAAIADAEQRGELALKDARNKLEGLEDALQKAKQDMARLLKEY
QELMNVKLALDVEIATYRKLLEGEECRLNGEGVGQVNISVTQSTVSSGYGGASGMGGGVGLGGG
SGYSYSSGHSLGGGFSSGSGRGISIGGGLSSVGGSTSSIKYTSSSSSRKSYKH

hide sequence

Protein Domains

IF rod

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000000943	ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000001279	ENTREZGENE
	ENSCLAT00000001279.1	UniProtKB/TrEMBL
Gene3D-CATH	1.20.5.170	UniProtKB/TrEMBL
	Single helix bin	UniProtKB/TrEMBL
	Vasodilator-stimulated phosphoprotein	UniProtKB/TrEMBL
InterPro	IF_conserved	UniProtKB/TrEMBL
	IF_rod_dom	UniProtKB/TrEMBL
	Keratin_2_head	UniProtKB/TrEMBL
	Keratin_II	UniProtKB/TrEMBL
NCBI Gene	LOC102010416	ENTREZGENE
PANTHER	GATA-TYPE DOMAIN-CONTAINING PROTEIN	UniProtKB/TrEMBL
	KERATIN, TYPE II CYTOSKELETAL 6A-RELATED	UniProtKB/TrEMBL
Pfam	Filament	UniProtKB/TrEMBL
	Keratin_2_head	UniProtKB/TrEMBL
PRINTS	TYPE2KERATIN	UniProtKB/TrEMBL
PROSITE	IF_ROD_1	UniProtKB/TrEMBL
	IF_ROD_2	UniProtKB/TrEMBL
SMART	Filament	UniProtKB/TrEMBL
Superfamily-SCOP	Intermediate filament protein, coiled coil region	UniProtKB/TrEMBL
UniProt	A0A8C2ULR2	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Krt6a	keratin 6A		keratin 6A, type II	Symbol and/or name change	5135510	APPROVED
2015-08-25	Krt6a	keratin 6A, type II	LOC102010416	keratin, type II cytoskeletal 6A-like	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - OMIM

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Imported Disease Annotations - ClinVar

Imported Disease Annotations - OMIM