Pappa2 (pappalysin 2) - Rat Genome Database

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Gene: Pappa2 (pappalysin 2) Chinchilla lanigera
Analyze
Symbol: Pappa2
Name: pappalysin 2
RGD ID: 8747732
Description: ENCODES a protein that exhibits metalloendopeptidase activity (ortholog); metallopeptidase activity (ortholog); INVOLVED IN bone morphogenesis (ortholog); proteolysis (ortholog); response to salt stress (ortholog); ASSOCIATED WITH 1q24 Deletion Syndrome (ortholog); autism spectrum disorder (ortholog); gastrointestinal stromal tumor (ortholog); FOUND IN apical plasma membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: pappalysin-2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540616,169,759 - 16,430,206 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540616,167,764 - 16,430,165 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074  


Genomics

Comparative Map Data
Pappa2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540616,169,759 - 16,430,206 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495540616,167,764 - 16,430,165 (+)NCBIChiLan1.0ChiLan1.0
PAPPA2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381176,463,175 - 176,845,601 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1176,463,171 - 176,845,601 (+)EnsemblGRCh38hg38GRCh38
GRCh371176,432,311 - 176,814,737 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361174,698,930 - 175,078,595 (+)NCBINCBI36Build 36hg18NCBI36
Build 341173,163,963 - 173,391,617NCBI
Celera1149,542,925 - 149,922,011 (+)NCBICelera
Cytogenetic Map1q25.2NCBI
HuRef1147,658,586 - 148,038,306 (+)NCBIHuRef
CHM1_11177,856,925 - 178,236,093 (+)NCBICHM1_1
T2T-CHM13v2.01175,818,447 - 176,200,273 (+)NCBIT2T-CHM13v2.0
Pappa2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391158,539,297 - 158,788,019 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1158,539,297 - 158,808,060 (-)EnsemblGRCm39 Ensembl
GRCm381158,711,727 - 158,960,451 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1158,711,727 - 158,980,490 (-)EnsemblGRCm38mm10GRCm38
MGSCv371160,641,862 - 160,887,569 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361160,548,404 - 160,794,115 (-)NCBIMGSCv36mm8
Celera1161,107,178 - 161,348,433 (-)NCBICelera
Cytogenetic Map1H1NCBI
cM Map168.49NCBI
Pappa2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81373,407,385 - 73,683,699 (-)NCBIGRCr8
mRatBN7.21370,873,918 - 71,147,874 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1370,876,794 - 71,147,779 (-)EnsemblmRatBN7.2 Ensembl
Rnor_6.01376,389,150 - 76,660,248 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1376,389,150 - 76,660,245 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01381,303,663 - 81,574,402 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41374,286,881 - 74,379,736 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1370,687,413 - 70,959,267 (-)NCBICelera
Cytogenetic Map13q22NCBI
PAPPA2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2172,873,318 - 73,515,794 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1172,543,742 - 73,186,283 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01151,727,598 - 152,369,670 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11155,675,710 - 156,066,753 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1155,769,395 - 156,063,989 (+)Ensemblpanpan1.1panPan2
PAPPA2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1722,769,594 - 23,038,458 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl722,772,715 - 23,036,517 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha722,294,142 - 22,562,649 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0722,516,581 - 22,785,586 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl722,519,707 - 22,982,506 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1722,422,261 - 22,697,383 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0722,522,272 - 22,790,785 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0722,665,408 - 22,932,430 (-)NCBIUU_Cfam_GSD_1.0
Pappa2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440934493,909,831 - 94,152,180 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648111,756,085 - 11,997,132 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493648111,756,580 - 11,998,919 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PAPPA2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9118,365,303 - 118,635,964 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19118,362,663 - 118,635,972 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29129,893,498 - 130,286,839 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PAPPA2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12552,432,178 - 52,729,671 (-)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366605554,003,379 - 54,316,468 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pappa2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247715,331,793 - 5,596,752 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247715,332,013 - 5,598,678 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000021958   ⟹   ENSCLAP00000021755
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495540616,169,759 - 16,430,206 (+)Ensembl
RefSeq Acc Id: XM_005374904   ⟹   XP_005374961
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540616,167,946 - 16,430,165 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013520972   ⟹   XP_013376426
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495540616,167,764 - 16,430,165 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005374961 (Get FASTA)   NCBI Sequence Viewer  
  XP_013376426 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000021755
  ENSCLAP00000021755.1
Reference Protein Sequences
RefSeq Acc Id: XP_005374961   ⟸   XM_005374904
- UniProtKB: A0A8C2W3R7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013376426   ⟸   XM_013520972
- UniProtKB: A0A8C2W3R7 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000021755   ⟸   ENSCLAT00000021958
Protein Domains
Sushi


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000014894 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000021958 ENTREZGENE
  ENSCLAT00000021958.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  3.40.390.10 UniProtKB/TrEMBL
  Complement Module, domain 1 UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  FN3_sf UniProtKB/TrEMBL
  LamG-like UniProtKB/TrEMBL
  MetalloPept_cat_dom_sf UniProtKB/TrEMBL
  Myxo_disulph_rpt UniProtKB/TrEMBL
  Notch_dom UniProtKB/TrEMBL
  PAPPA/PAPPA2 UniProtKB/TrEMBL
  Peptidase_M43 UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/TrEMBL
NCBI Gene Pappa2 ENTREZGENE
PANTHER PTHR46130 UniProtKB/TrEMBL
  PTHR46130:SF1 UniProtKB/TrEMBL
Pfam Laminin_G_3 UniProtKB/TrEMBL
  Notch UniProtKB/TrEMBL
  Peptidase_M43 UniProtKB/TrEMBL
  Sushi UniProtKB/TrEMBL
PROSITE SUSHI UniProtKB/TrEMBL
SMART CCP UniProtKB/TrEMBL
  LamGL UniProtKB/TrEMBL
  SM00004 UniProtKB/TrEMBL
Superfamily-SCOP Metalloproteases ('zincins'), catalytic domain UniProtKB/TrEMBL
  SSF49265 UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
  SSF57535 UniProtKB/TrEMBL
UniProt A0A8C2W3R7 ENTREZGENE, UniProtKB/TrEMBL