Grb10 (growth factor receptor bound protein 10) - Rat Genome Database

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Gene: Grb10 (growth factor receptor bound protein 10) Chinchilla lanigera
Analyze
Symbol: Grb10
Name: growth factor receptor bound protein 10
RGD ID: 8745881
Description: ENCODES a protein that exhibits identical protein binding (ortholog); insulin receptor binding (ortholog); protein-macromolecule adaptor activity (ortholog); INVOLVED IN ERK1 and ERK2 cascade (ortholog); gene expression (ortholog); insulin receptor signaling pathway (ortholog); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; platelet-derived growth factor signaling pathway; ASSOCIATED WITH COVID-19 (ortholog); genetic disease (ortholog); pleomorphic xanthoastrocytoma (ortholog); FOUND IN protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: growth factor receptor-bound protein 10
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554563,470,330 - 3,509,667 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554563,405,730 - 3,508,967 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Grb10
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554563,470,330 - 3,509,667 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554563,405,730 - 3,508,967 (+)NCBIChiLan1.0ChiLan1.0
GRB10
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38750,590,068 - 50,793,453 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl750,590,063 - 50,793,462 (-)EnsemblGRCh38hg38GRCh38
GRCh37750,657,765 - 50,861,150 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36750,625,259 - 50,828,652 (-)NCBINCBI36Build 36hg18NCBI36
Build 34750,431,974 - 50,574,259NCBI
Celera750,722,672 - 50,926,043 (-)NCBICelera
Cytogenetic Map7p12.1NCBI
HuRef750,507,724 - 50,673,735 (-)NCBIHuRef
CHM1_1750,660,053 - 50,863,458 (-)NCBICHM1_1
T2T-CHM13v2.0750,751,214 - 50,954,643 (-)NCBIT2T-CHM13v2.0
CRA_TCAGchr7v2750,663,826 - 50,867,195 (-)NCBI
Grb10
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391111,880,499 - 11,987,428 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1111,880,508 - 11,988,683 (-)EnsemblGRCm39 Ensembl
GRCm381111,930,499 - 12,037,428 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1111,930,508 - 12,038,683 (-)EnsemblGRCm38mm10GRCm38
MGSCv371111,830,502 - 11,937,423 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361111,830,511 - 11,937,358 (-)NCBIMGSCv36mm8
Celera1112,389,743 - 12,487,174 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map117.15NCBI
Grb10
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81490,708,653 - 90,816,399 (-)NCBIGRCr8
mRatBN7.21486,495,051 - 86,602,800 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1486,495,054 - 86,602,806 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1490,900,844 - 91,008,544 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01492,145,178 - 92,252,882 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01488,612,820 - 88,720,522 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01492,021,851 - 92,122,249 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1492,021,851 - 92,117,923 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01491,818,383 - 91,914,937 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41492,814,797 - 92,911,442 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
Celera1485,495,882 - 85,591,916 (-)NCBICelera
Cytogenetic Map14q21NCBI
GRB10
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2655,467,134 - 55,670,188 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan17103,791,857 - 103,995,352 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0751,230,945 - 51,434,560 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1751,474,166 - 51,676,864 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl751,474,166 - 51,666,638 (-)Ensemblpanpan1.1panPan2
GRB10
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1181,890,689 - 2,014,836 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl181,890,792 - 2,014,839 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha181,881,459 - 2,037,594 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0181,948,998 - 2,105,497 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl181,949,030 - 2,072,043 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1181,921,393 - 2,077,726 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0181,917,858 - 2,074,464 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0182,055,100 - 2,210,940 (-)NCBIUU_Cfam_GSD_1.0
Grb10
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118105,243,956 - 105,420,568 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366861,201,882 - 1,279,600 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366861,102,706 - 1,279,594 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
GRB10
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl9136,580,362 - 136,741,756 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.19136,580,363 - 136,742,552 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.29150,268,567 - 150,398,500 (-)NCBISscrofa10.2Sscrofa10.2susScr3
GRB10
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1218,022,483 - 8,225,339 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl218,063,238 - 8,225,664 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606214,134,900 - 14,353,540 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Grb10
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247403,628,252 - 3,668,151 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247403,562,758 - 3,668,761 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000017492   ⟹   ENSCLAP00000017323
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554563,470,330 - 3,509,667 (+)Ensembl
RefSeq Acc Id: XM_005396599   ⟹   XP_005396656
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554563,405,730 - 3,508,967 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005396600   ⟹   XP_005396657
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554563,405,730 - 3,508,967 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013520627   ⟹   XP_013376081
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554563,405,730 - 3,508,967 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005396656 (Get FASTA)   NCBI Sequence Viewer  
  XP_005396657 (Get FASTA)   NCBI Sequence Viewer  
  XP_013376081 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000017323
  ENSCLAP00000017323.1
Reference Protein Sequences
RefSeq Acc Id: XP_005396656   ⟸   XM_005396599
- Peptide Label: isoform X2
- UniProtKB: A0A8C2VTK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005396657   ⟸   XM_005396600
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VTK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013376081   ⟸   XM_013520627
- Peptide Label: isoform X1
- UniProtKB: A0A8C2VTK4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000017323   ⟸   ENSCLAT00000017492
Protein Domains
PH   Ras-associating   SH2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011895 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000017492 ENTREZGENE
  ENSCLAT00000017492.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.29.30 UniProtKB/TrEMBL
  3.30.505.10 UniProtKB/TrEMBL
InterPro BPS-dom UniProtKB/TrEMBL
  GRB/APBB1IP UniProtKB/TrEMBL
  Grb10_SH2 UniProtKB/TrEMBL
  PH-like_dom_sf UniProtKB/TrEMBL
  PH_APBB1IP UniProtKB/TrEMBL
  PH_domain UniProtKB/TrEMBL
  RA_dom UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
  SH2_dom_sf UniProtKB/TrEMBL
  Ubiquitin-like_domsf UniProtKB/TrEMBL
NCBI Gene Grb10 ENTREZGENE
PANTHER PTHR11243 UniProtKB/TrEMBL
  PTHR11243:SF4 UniProtKB/TrEMBL
Pfam BPS UniProtKB/TrEMBL
  PF00169 UniProtKB/TrEMBL
  PF00788 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
PRINTS SH2DOMAIN UniProtKB/TrEMBL
PROSITE PH_DOMAIN UniProtKB/TrEMBL
  PS50200 UniProtKB/TrEMBL
  SH2 UniProtKB/TrEMBL
SMART SH2 UniProtKB/TrEMBL
  SM00233 UniProtKB/TrEMBL
  SM00314 UniProtKB/TrEMBL
Superfamily-SCOP PH domain-like UniProtKB/TrEMBL
  SSF54236 UniProtKB/TrEMBL
  SSF55550 UniProtKB/TrEMBL
UniProt A0A8C2VTK4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Grb10  growth factor receptor bound protein 10    growth factor receptor-bound protein 10  Symbol and/or name change 5135510 APPROVED