Slit2 (slit guidance ligand 2) - Rat Genome Database

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Gene: Slit2 (slit guidance ligand 2) Chinchilla lanigera
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Symbol: Slit2
Name: slit guidance ligand 2
RGD ID: 8740232
Description: ENCODES a protein that exhibits chemorepellent activity (ortholog); GTPase inhibitor activity (ortholog); heparan sulfate proteoglycan binding (ortholog); INVOLVED IN aortic valve morphogenesis (ortholog); apoptotic process involved in luteolysis (ortholog); axon extension involved in axon guidance (ortholog); PARTICIPATES IN glypican signaling pathway; ASSOCIATED WITH acute promyelocytic leukemia (ortholog); anti-basement membrane glomerulonephritis (ortholog); atrial fibrillation (ortholog); FOUND IN axon (ortholog); cell body (ortholog); cell projection (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: slit homolog 2
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554803,984,586 - 4,313,908 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554803,982,977 - 4,314,160 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aortic valve morphogenesis  (ISO)
apoptotic process involved in luteolysis  (ISO)
axon extension involved in axon guidance  (ISO)
axon guidance  (ISO)
axonogenesis  (ISO)
branching morphogenesis of an epithelial tube  (ISO)
cell migration involved in sprouting angiogenesis  (ISO)
cell-cell adhesion  (ISO)
cellular response to heparin  (ISO)
cellular response to hormone stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration  (ISO)
chemorepulsion involved in postnatal olfactory bulb interneuron migration  (ISO)
corticospinal neuron axon guidance through spinal cord  (ISO)
dorsal/ventral axon guidance  (ISO)
in utero embryonic development  (ISO)
induction of negative chemotaxis  (ISO)
kidney development  (ISO)
mammary duct terminal end bud growth  (ISO)
mammary gland duct morphogenesis  (ISO)
metanephros development  (ISO)
motor neuron axon guidance  (ISO)
negative chemotaxis  (ISO)
negative regulation of actin filament polymerization  (ISO)
negative regulation of axon extension  (ISO)
negative regulation of cell growth  (ISO)
negative regulation of cell migration  (ISO)
negative regulation of cell population proliferation  (ISO)
negative regulation of cellular response to growth factor stimulus  (ISO)
negative regulation of chemokine-mediated signaling pathway  (ISO)
negative regulation of endothelial cell migration  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of lamellipodium assembly  (ISO)
negative regulation of leukocyte chemotaxis  (ISO)
negative regulation of monocyte chemotaxis  (ISO)
negative regulation of mononuclear cell migration  (ISO)
negative regulation of neutrophil chemotaxis  (ISO)
negative regulation of protein phosphorylation  (ISO)
negative regulation of retinal ganglion cell axon guidance  (ISO)
negative regulation of small GTPase mediated signal transduction  (ISO)
negative regulation of smooth muscle cell chemotaxis  (ISO)
negative regulation of smooth muscle cell migration  (ISO)
negative regulation of vascular permeability  (ISO)
neuron projection extension  (ISO)
neuron projection morphogenesis  (ISO)
olfactory bulb development  (ISO)
positive regulation of apoptotic process  (ISO)
positive regulation of synapse assembly  (ISO)
pulmonary valve morphogenesis  (ISO)
response to cortisol  (ISO)
response to nutrient levels  (ISO)
retinal ganglion cell axon guidance  (ISO)
Roundabout signaling pathway  (ISO)
spinal cord development  (ISO)
synapse maturation  (ISO)
telencephalon cell migration  (ISO)
ureteric bud development  (ISO)
ventricular septum morphogenesis  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Slit2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554803,984,586 - 4,313,908 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554803,982,977 - 4,314,160 (-)NCBIChiLan1.0ChiLan1.0
SLIT2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38420,251,905 - 20,620,561 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl420,251,905 - 20,620,561 (+)EnsemblGRCh38hg38GRCh38
GRCh37420,253,528 - 20,622,184 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36419,864,333 - 20,229,886 (+)NCBINCBI36Build 36hg18NCBI36
Build 34419,931,503 - 20,297,057NCBI
Celera420,712,350 - 21,077,291 (+)NCBICelera
Cytogenetic Map4p15.31NCBI
HuRef419,604,199 - 19,969,514 (+)NCBIHuRef
CHM1_1420,253,276 - 20,618,733 (+)NCBICHM1_1
T2T-CHM13v2.0420,234,597 - 20,602,238 (+)NCBIT2T-CHM13v2.0
Slit2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39548,138,633 - 48,465,077 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl548,140,480 - 48,465,075 (+)EnsemblGRCm39 Ensembl
GRCm38547,981,291 - 48,307,735 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl547,983,138 - 48,307,733 (+)EnsemblGRCm38mm10GRCm38
MGSCv37548,374,394 - 48,697,017 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36548,273,041 - 48,593,759 (+)NCBIMGSCv36mm8
Celera545,381,658 - 45,708,133 (+)NCBICelera
Cytogenetic Map5B3NCBI
cM Map526.05NCBI
Slit2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81466,829,661 - 67,168,517 (-)NCBIGRCr8
mRatBN7.21462,616,337 - 62,955,934 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1462,617,067 - 62,955,948 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1467,016,997 - 67,353,404 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01468,330,637 - 68,667,055 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01464,727,393 - 65,063,822 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01466,831,848 - 67,171,491 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1466,831,848 - 67,170,361 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01466,864,065 - 67,202,691 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41467,546,283 - 67,891,840 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11467,624,799 - 67,894,206 (-)NCBI
Celera1461,665,582 - 62,001,006 (-)NCBICelera
Cytogenetic Map14q11NCBI
SLIT2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2320,490,764 - 20,869,771 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1420,698,666 - 21,066,091 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0414,654,448 - 15,023,708 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1419,946,369 - 20,314,656 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl420,158,952 - 20,314,656 (+)Ensemblpanpan1.1panPan2
SLIT2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1388,964,707 - 89,311,817 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl388,966,232 - 89,312,955 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha391,423,926 - 91,773,328 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0389,948,981 - 90,297,465 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl389,948,988 - 90,298,073 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1389,094,518 - 89,443,898 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0389,179,097 - 89,528,769 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0389,562,948 - 89,912,569 (-)NCBIUU_Cfam_GSD_1.0
Slit2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440528554,409,516 - 54,746,912 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049364778,109,228 - 8,446,653 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049364778,111,212 - 8,448,567 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
SLIT2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl814,758,335 - 15,148,133 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1814,758,426 - 15,149,515 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2814,998,769 - 15,257,500 (+)NCBISscrofa10.2Sscrofa10.2susScr3
SLIT2
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12729,650,589 - 30,020,105 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl2729,650,337 - 29,803,612 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366604776,267,556 - 76,654,726 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Slit2
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462475511,472,377 - 11,819,266 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462475511,470,810 - 11,819,800 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000001959   ⟹   ENSCLAP00000001915
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554803,984,586 - 4,313,908 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000001960   ⟹   ENSCLAP00000001916
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554803,984,586 - 4,313,908 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000001961   ⟹   ENSCLAP00000001917
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554803,984,586 - 4,313,908 (-)Ensembl
Ensembl Acc Id: ENSCLAT00000001962   ⟹   ENSCLAP00000001918
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554803,984,586 - 4,313,908 (-)Ensembl
RefSeq Acc Id: XM_005402476   ⟹   XP_005402533
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554803,982,977 - 4,314,160 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005402478   ⟹   XP_005402535
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554803,982,977 - 4,314,160 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005402479   ⟹   XP_005402536
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554803,982,977 - 4,314,160 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013503310   ⟹   XP_013358764
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554803,982,977 - 4,314,160 (-)NCBI
Sequence:
RefSeq Acc Id: XP_005402536   ⟸   XM_005402479
- Peptide Label: isoform X4
- UniProtKB: A0A8C2YIV9 (UniProtKB/TrEMBL),   A0A8C2UJR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005402533   ⟸   XM_005402476
- Peptide Label: isoform X2
- UniProtKB: A0A8C2UJR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005402535   ⟸   XM_005402478
- Peptide Label: isoform X3
- UniProtKB: A0A8C2YIV4 (UniProtKB/TrEMBL),   A0A8C2UJR6 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013358764   ⟸   XM_013503310
- Peptide Label: isoform X1
- UniProtKB: A0A8C2ULL3 (UniProtKB/TrEMBL),   A0A8C2UJR6 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000001917   ⟸   ENSCLAT00000001961
Ensembl Acc Id: ENSCLAP00000001916   ⟸   ENSCLAT00000001960
Ensembl Acc Id: ENSCLAP00000001918   ⟸   ENSCLAT00000001962
Ensembl Acc Id: ENSCLAP00000001915   ⟸   ENSCLAT00000001959
Protein Domains
CTCK   EGF-like   Laminin G


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001413 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000001959.1 UniProtKB/TrEMBL
  ENSCLAT00000001960 ENTREZGENE
  ENSCLAT00000001960.1 UniProtKB/TrEMBL
  ENSCLAT00000001961 ENTREZGENE
  ENSCLAT00000001961.1 UniProtKB/TrEMBL
  ENSCLAT00000001962 ENTREZGENE
  ENSCLAT00000001962.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.200 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
  Laminin UniProtKB/TrEMBL
InterPro ConA-like_dom_sf UniProtKB/TrEMBL
  Cys-rich_flank_reg_C UniProtKB/TrEMBL
  Cys_knot_C UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_CS UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  EGF-type_Asp/Asn_hydroxyl_site UniProtKB/TrEMBL
  EGF_Ca-bd_CS UniProtKB/TrEMBL
  Fol_N UniProtKB/TrEMBL
  Laminin_G UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  LRR_dom_sf UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
  Notch/Slit_guidance UniProtKB/TrEMBL
NCBI Gene Slit2 ENTREZGENE
PANTHER SLIT HOMOLOG UniProtKB/TrEMBL
  SLIT HOMOLOG 2 PROTEIN UniProtKB/TrEMBL
Pfam EGF UniProtKB/TrEMBL
  hEGF UniProtKB/TrEMBL
  Laminin_G_1 UniProtKB/TrEMBL
  LRR_1 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
PROSITE ASX_HYDROXYL UniProtKB/TrEMBL
  CTCK_1 UniProtKB/TrEMBL
  CTCK_2 UniProtKB/TrEMBL
  EGF_1 UniProtKB/TrEMBL
  EGF_2 UniProtKB/TrEMBL
  EGF_3 UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  LAM_G_DOMAIN UniProtKB/TrEMBL
  LRR UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  FOLN UniProtKB/TrEMBL
  LamG UniProtKB/TrEMBL
  LRR_SD22 UniProtKB/TrEMBL
  LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  LRRNT UniProtKB/TrEMBL
  SM00041 UniProtKB/TrEMBL
Superfamily-SCOP EGF/Laminin UniProtKB/TrEMBL
  L domain-like UniProtKB/TrEMBL
  SSF49899 UniProtKB/TrEMBL
UniProt A0A8C2UJR6 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2ULL3 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YIV4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YIV9 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Slit2  slit guidance ligand 2    slit homolog 2 (Drosophila)  Symbol and/or name change 5135510 APPROVED