Otud4 (OTU deubiquitinase 4) - Rat Genome Database

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Gene: Otud4 (OTU deubiquitinase 4) Chinchilla lanigera
Analyze
Symbol: Otud4
Name: OTU deubiquitinase 4
RGD ID: 8738818
Description: ENCODES a protein that exhibits cysteine-type deubiquitinase activity (ortholog); K63-linked deubiquitinase activity (ortholog); molecular adaptor activity (ortholog); INVOLVED IN DNA alkylation repair (ortholog); negative regulation of interleukin-1-mediated signaling pathway (ortholog); negative regulation of toll-like receptor signaling pathway (ortholog); ASSOCIATED WITH amenorrhea (ortholog); genetic disease (ortholog); FOUND IN cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: OTU domain containing 4; OTU domain-containing protein 4
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554281,062,998 - 1,115,415 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554281,062,998 - 1,108,711 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
cytosol  (ISO)

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:30032202  


Genomics

Comparative Map Data
Otud4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554281,062,998 - 1,115,415 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554281,062,998 - 1,108,711 (-)NCBIChiLan1.0ChiLan1.0
OTUD4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh384145,133,650 - 145,180,589 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl4145,110,838 - 145,180,589 (-)EnsemblGRCh38hg38GRCh38
GRCh374146,054,802 - 146,101,741 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364146,274,252 - 146,320,282 (-)NCBINCBI36Build 36hg18NCBI36
Celera4143,382,143 - 143,428,339 (-)NCBICelera
Cytogenetic Map4q31.21NCBI
HuRef4141,786,122 - 141,832,147 (-)NCBIHuRef
CHM1_14146,031,068 - 146,077,284 (-)NCBICHM1_1
T2T-CHM13v2.04148,451,040 - 148,497,987 (-)NCBIT2T-CHM13v2.0
Otud4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39880,366,305 - 80,404,384 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl880,366,247 - 80,404,353 (+)EnsemblGRCm39 Ensembl
GRCm38879,639,676 - 79,677,755 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl879,639,618 - 79,677,724 (+)EnsemblGRCm38mm10GRCm38
MGSCv37882,163,575 - 82,201,654 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36882,535,748 - 82,573,827 (+)NCBIMGSCv36mm8
Celera883,915,553 - 83,953,642 (+)NCBICelera
Cytogenetic Map8C1NCBI
cM Map837.74NCBI
Otud4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81945,141,043 - 45,184,136 (-)NCBIGRCr8
mRatBN7.21928,236,713 - 28,279,815 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1928,236,713 - 28,279,815 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1935,097,012 - 35,140,127 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01935,751,086 - 35,794,201 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01937,985,978 - 38,029,120 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01931,895,753 - 31,942,509 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1931,899,087 - 31,942,180 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01942,799,728 - 42,846,155 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41930,124,849 - 30,167,942 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11930,129,291 - 30,172,543 (-)NCBI
Celera1927,744,764 - 27,787,846 (-)NCBICelera
Cytogenetic Map19q11NCBI
OTUD4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v23143,014,271 - 143,065,786 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan14143,379,154 - 143,430,674 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v04137,480,809 - 137,527,651 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.14149,141,513 - 149,187,333 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4149,135,900 - 149,182,476 (-)Ensemblpanpan1.1panPan2
OTUD4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11543,816,656 - 43,861,813 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1543,818,196 - 43,861,784 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1544,208,727 - 44,253,896 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01544,485,491 - 44,530,755 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1544,488,609 - 44,531,432 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11543,758,510 - 43,803,683 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01543,845,139 - 43,890,348 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01544,109,586 - 44,154,745 (-)NCBIUU_Cfam_GSD_1.0
Otud4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440530146,475,249 - 46,513,834 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365353,912,606 - 3,951,503 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365353,911,904 - 3,950,675 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
OTUD4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl883,240,754 - 83,288,234 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1883,240,759 - 83,288,237 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2888,519,444 - 88,558,932 (+)NCBISscrofa10.2Sscrofa10.2susScr3
OTUD4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1791,709,184 - 91,756,437 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl791,708,767 - 91,756,793 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603771,349,422 - 71,397,341 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Otud4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248534,091,316 - 4,140,201 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248534,091,591 - 4,145,344 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000006550   ⟹   ENSCLAP00000006443
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554281,062,998 - 1,108,102 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000006551   ⟹   ENSCLAP00000006444
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554281,066,721 - 1,115,415 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000006552   ⟹   ENSCLAP00000006445
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554281,066,721 - 1,108,102 (-)Ensembl
RefSeq Acc Id: XM_005386641   ⟹   XP_005386698
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554281,062,998 - 1,108,711 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013515277   ⟹   XP_013370731
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554281,062,998 - 1,108,711 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005386698 (Get FASTA)   NCBI Sequence Viewer  
  XP_013370731 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000006443
  ENSCLAP00000006443.1
  ENSCLAP00000006444.1
  ENSCLAP00000006445
  ENSCLAP00000006445.1
Reference Protein Sequences
RefSeq Acc Id: XP_005386698   ⟸   XM_005386641
- Peptide Label: isoform X1
- UniProtKB: A0A8C2YL11 (UniProtKB/TrEMBL),   A0A8C2UWQ0 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013370731   ⟸   XM_013515277
- Peptide Label: isoform X2
- UniProtKB: A0A8C2V1Z8 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000006445   ⟸   ENSCLAT00000006552
RefSeq Acc Id: ENSCLAP00000006444   ⟸   ENSCLAT00000006551
RefSeq Acc Id: ENSCLAP00000006443   ⟸   ENSCLAT00000006550
Protein Domains
OTU


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000004554 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000006550 ENTREZGENE
  ENSCLAT00000006550.1 UniProtKB/TrEMBL
  ENSCLAT00000006551.1 UniProtKB/TrEMBL
  ENSCLAT00000006552 ENTREZGENE
  ENSCLAT00000006552.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.70.80 UniProtKB/TrEMBL
InterPro OTU_dom UniProtKB/TrEMBL
  Papain-like_cys_pep_sf UniProtKB/TrEMBL
NCBI Gene Otud4 ENTREZGENE
PANTHER OTU DOMAIN CONTAINING PROTEIN UniProtKB/TrEMBL
  OTU DOMAIN-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
Pfam OTU UniProtKB/TrEMBL
PROSITE OTU UniProtKB/TrEMBL
Superfamily-SCOP SSF54001 UniProtKB/TrEMBL
UniProt A0A8C2UWQ0 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2V1Z8 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2YL11 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-08-25 Otud4  OTU deubiquitinase 4    OTU domain containing 4  Symbol and/or name change 5135510 APPROVED