Gtf2h3 (general transcription factor IIH subunit 3)

Gene: Gtf2h3 (general transcription factor IIH subunit 3) Chinchilla lanigera

Analyze

Symbol:

Gtf2h3

Name:

general transcription factor IIH subunit 3

RGD ID:

8735776

Description:

ENCODES a protein that exhibits RNA polymerase II general transcription initiation factor activity (ortholog); INVOLVED IN transcription by RNA polymerase II (ortholog); PARTICIPATES IN RNA polymerase II transcription initiation pathway; ASSOCIATED WITH genetic disease (ortholog); Joubert syndrome 1 (ortholog); FOUND IN core TFIIH complex portion of holo TFIIH complex (ortholog); nucleoplasm (ortholog); nucleus (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

general transcription factor IIH, polypeptide 3, 34kDa

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	5,365,142 - 5,380,047 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955482	5,365,669 - 5,380,047 (-)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Joubert syndrome 1 (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

transcription by RNA polymerase II (ISO)

Cellular Component

core TFIIH complex portion of holo TFIIH complex (ISO)

nucleoplasm (ISO)

nucleus (ISO)

transcription factor TFIID complex (ISO)

transcription factor TFIIH holo complex (ISO)

transcription preinitiation complex (ISO)

Molecular Function

protein binding (ISO)

RNA polymerase II general transcription initiation factor activity (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

RNA polymerase II transcription initiation pathway (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:22301074	PMID:30032202

Genomics

Comparative Map Data

Gtf2h3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955482	5,365,142 - 5,380,047 (-)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955482	5,365,669 - 5,380,047 (-)	NCBI	ChiLan1.0	ChiLan1.0

GTF2H3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	12	123,633,829 - 123,662,604 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	12	123,633,739 - 123,662,604 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	12	124,118,376 - 124,147,151 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	12	122,684,334 - 122,711,287 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	12	122,643,260 - 122,670,214	NCBI
Celera	12	123,714,817 - 123,741,772 (+)	NCBI		Celera
Cytogenetic Map	12	q24.31	NCBI
HuRef	12	121,079,532 - 121,108,395 (+)	NCBI		HuRef
CHM1_1	12	123,939,235 - 123,968,101 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	12	123,632,693 - 123,661,470 (+)	NCBI		T2T-CHM13v2.0

Gtf2h3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	124,717,211 - 124,735,743 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	124,717,203 - 124,735,743 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	124,579,148 - 124,597,680 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	124,579,140 - 124,597,680 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	125,029,157 - 125,047,689 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	124,839,789 - 124,857,459 (+)	NCBI		MGSCv36	mm8
Celera	5	121,655,848 - 121,674,546 (+)	NCBI		Celera
Cytogenetic Map	5	F	NCBI
cM Map	5	63.67	NCBI

Gtf2h3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	12	37,669,995 - 37,687,505 (-)	NCBI		GRCr8
mRatBN7.2	12	32,009,010 - 32,025,484 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	12	32,009,014 - 32,025,497 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	12	33,187,754 - 33,203,819 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	12	33,799,075 - 33,815,140 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	12	32,850,942 - 32,867,007 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	12	37,427,556 - 37,444,027 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	12	37,427,546 - 37,444,282 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	12	39,298,569 - 39,315,037 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	12	33,121,881 - 33,138,233 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	12	32,985,270 - 33,001,621 (-)	NCBI
Celera	12	33,698,431 - 33,714,902 (-)	NCBI		Celera
Cytogenetic Map	12	q15	NCBI

GTF2H3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	10	131,708,349 - 131,737,682 (+)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	12	131,704,710 - 131,734,059 (+)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	12	121,218,813 - 121,246,807 (+)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	12	125,445,381 - 125,473,763 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	12	125,445,381 - 125,473,763 (+)	Ensembl	panpan1.1		panPan2

GTF2H3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	26	5,985,094 - 6,011,253 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	26	5,985,798 - 6,011,163 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	26	6,147,525 - 6,174,121 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	26	6,234,737 - 6,261,341 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	26	6,234,495 - 6,261,295 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	26	6,168,228 - 6,194,816 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	26	6,260,228 - 6,287,181 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	26	6,213,786 - 6,240,388 (-)	NCBI		UU_Cfam_GSD_1.0

Gtf2h3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	158,283,347 - 158,304,710 (+)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936558	1,173,064 - 1,196,063 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936558	1,176,154 - 1,196,028 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

GTF2H3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	14	29,335,582 - 29,355,435 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	14	29,335,715 - 29,355,465 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	14	31,029,684 - 31,047,752 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

GTF2H3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	11	118,961,907 - 118,989,906 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	11	118,967,974 - 118,989,391 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666037	126,285,426 - 126,313,975 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Gtf2h3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624747	23,422,319 - 23,435,926 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624747	23,422,289 - 23,437,193 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005403024	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01057326	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDI01067699	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000013925 ⟹ ENSCLAP00000013770

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955482	5,365,142 - 5,380,047 (-)	Ensembl

RefSeq Acc Id:

XM_005403024 ⟹ XP_005403081

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955482	5,365,669 - 5,380,047 (-)	NCBI

Sequence:

show sequence

CGCCGGAAGTCGGGGTGCGCAGGCTTCAGAACGCTCGCCACACGGCTGCTCGCTTTGCTTTGAG
AGCAGGGAGTCGCCATGGTTTCTGACGAAGATGAATTGAATCTTCTGGTCATCGTAGTTGATAC
CAACCCAATTTGGTGGGGGAAGCAAGCATTAAAGGAATCTCAGTTCACCCTGTCCCGATGCATG
GATGCCGTGCTGGTGCTGGGGAACGCCCACCTGTTCATGAACCGCTGCAACCAGCTGGCCGTGA
TCGCCAGCCACATTCATGAGAGTCGATTCTTGTATCCTGGGAAGAACGGCAGACTGGGAGACTT
CTTTGGAGACCCCGGCAACCCCCCTCCTGAATACAATCCCTCGGGGAGTAAAGACGGCAAATAT
GAGCTGTTGACGGCAGCCAACGATGTGATAGTGGAGGAGATGAAAGATCTGATGACCAAGAGTG
ACATAAAGGGTCAACACACAGAGACTCTGCTGGCCGGATCCCTCGCCAAAGCCCTGTGCTATAT
TCATAGAATGAACAAAGAAGTTAAAGATAATCAAGAGATGAAGTCAAGGATATTGGTGATCAAG
GCCGCGGAGGACAGCGCCCTGCAATACATGAACTTCATGAACGTCATCTTTGCCGCGCAGAAGC
AGAGTATTTTGATCGATGCCTGTGTTTTAGACTCCGACTCAGGACTCCTCCAGCAGGCCTGTGA
CATCACGGGAGGACTATACCTCAAGGTGCCCCAGATGACGTCCCTGCTGCAGTACTTACTGTGG
GTTTTTCTCCCTGATCAAGATCAGAGAACACAGTTAATCCTCCCGCCCCCGATTCATGTTGACT
ACCGGGCGGCTTGCTTCTGTCACCGGAATCTCATTGAGATCGGCTACGTGTGCTCTGTGTGTCT
GTCGATCTTCTGCAACTTCAGCCCCATCTGCACCACGTGTGAGACGGCCTTTAAGATCTCTCTC
CCACCTGTGCTGAAGGCCAAGAAGAAGAAACTGAAGTCATCTGCGTGATACAGCGGGATTTCTT
TAAGGCTTTTTTTTTTTGGTCCTGGAAATTGAACTCAGGACCTTGTGCCCGTCAGGCAGGATCT
TGGGCTGCTGAGCTGTGTCCCCGGCCCCTTTAAGGCTATTATGACTAATAAGCGTGTGGAAGAA
CCTTTGTGGGAAGACTGAACAACACAGATCTGTGCAGGGTGGCTTTAGTGTCGCAAGCGTCCCA
TGGGGCATAGTCCAAAGTGTCACCCCCCTGCGCCGCGCGCATCCTGCAGTCTGGTCTGGCCGGG
GGGAAGCGCAGCTTGGTGACTCTGACTTTATCAGTGGGCTCGGTGGTCAAAGCTGGCCTGCCGA
GACCAATCCTGGCTCCAGTCCTCTGCCCCGTTCTGCACACTCACTGTGACGTTGGAGCCGGCGC
TGGAGGCAGTGAGCGTGTGCAGAGCTCAGCTGTAACAGCAGCAGCACGAGTGAATCGGCATCGC
CTTTCCAGTGACCGAGCAGAAATAAAGCCTGTGTCTACCCTGGGGGTCAGCTGCAGA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005403081	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000013770
	ENSCLAP00000013770.1

RefSeq Acc Id:

XP_005403081 ⟸ XM_005403024

- UniProtKB:

A0A8C2VGU8 (UniProtKB/TrEMBL)

- Sequence:

show sequence

MVSDEDELNLLVIVVDTNPIWWGKQALKESQFTLSRCMDAVLVLGNAHLFMNRCNQLAVIASHI
HESRFLYPGKNGRLGDFFGDPGNPPPEYNPSGSKDGKYELLTAANDVIVEEMKDLMTKSDIKGQ
HTETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNVIFAAQKQSILI
DACVLDSDSGLLQQACDITGGLYLKVPQMTSLLQYLLWVFLPDQDQRTQLILPPPIHVDYRAAC
FCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAKKKKLKSSA

hide sequence

RefSeq Acc Id:

ENSCLAP00000013770 ⟸ ENSCLAT00000013925

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000009518	Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000013925	ENTREZGENE
	ENSCLAT00000013925.1	UniProtKB/TrEMBL
Gene3D-CATH	3.40.50.410	UniProtKB/TrEMBL
InterPro	TFIIH_Tfb4/GTF2H3	UniProtKB/TrEMBL
	vWFA_dom_sf	UniProtKB/TrEMBL
NCBI Gene	Gtf2h3	ENTREZGENE
PANTHER	GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 3	UniProtKB/TrEMBL
	PTHR12831	UniProtKB/TrEMBL
Pfam	Tfb4	UniProtKB/TrEMBL
UniProt	A0A8C2VGU8	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-16	Gtf2h3	general transcription factor IIH subunit 3		general transcription factor IIH, polypeptide 3, 34kDa	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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Imported Disease Annotations - ClinVar

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