Fap (fibroblast activation protein alpha) - Rat Genome Database

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Gene: Fap (fibroblast activation protein alpha) Chinchilla lanigera
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Symbol: Fap
Name: fibroblast activation protein alpha
RGD ID: 8729092
Description: ENCODES a protein that exhibits dipeptidyl-peptidase activity (ortholog); endopeptidase activity (ortholog); identical protein binding (ortholog); INVOLVED IN endothelial cell migration (ortholog); melanocyte apoptotic process (ortholog); melanocyte proliferation (ortholog); ASSOCIATED WITH autistic disorder (ortholog); esophagus squamous cell carcinoma (ortholog); genetic disease (ortholog); FOUND IN apical part of cell (ortholog); basal part of cell (ortholog); cell surface (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: fibroblast activation protein, alpha; prolyl endopeptidase FAP
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544911,623,741 - 11,694,335 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544911,623,838 - 11,694,256 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Fap
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495544911,623,741 - 11,694,335 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495544911,623,838 - 11,694,256 (+)NCBIChiLan1.0ChiLan1.0
FAP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh382162,170,684 - 162,243,445 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl2162,170,684 - 162,245,151 (-)EnsemblGRCh38hg38GRCh38
GRCh372163,027,194 - 163,099,955 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 362162,735,446 - 162,808,291 (-)NCBINCBI36Build 36hg18NCBI36
Build 342162,852,708 - 162,925,552NCBI
Celera2156,637,516 - 156,710,361 (-)NCBICelera
Cytogenetic Map2q24.2NCBI
HuRef2154,909,562 - 154,982,406 (-)NCBIHuRef
CHM1_12163,033,090 - 163,105,931 (-)NCBICHM1_1
T2T-CHM13v2.02162,627,338 - 162,700,099 (-)NCBIT2T-CHM13v2.0
Fap
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39262,331,280 - 62,404,365 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl262,331,287 - 62,404,419 (-)EnsemblGRCm39 Ensembl
GRCm38262,500,936 - 62,575,509 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl262,500,943 - 62,574,075 (-)EnsemblGRCm38mm10GRCm38
MGSCv37262,339,002 - 62,412,078 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36262,301,784 - 62,374,860 (-)NCBIMGSCv36mm8
Celera264,191,101 - 64,264,176 (-)NCBICelera
Cytogenetic Map2C1.3NCBI
cM Map235.85NCBI
Fap
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr8367,547,398 - 67,616,271 (-)NCBIGRCr8
mRatBN7.2347,138,823 - 47,207,671 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl347,138,813 - 47,225,545 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx350,493,843 - 50,562,306 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0359,077,377 - 59,145,833 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0356,850,389 - 56,919,037 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.0348,467,781 - 48,536,242 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl348,467,781 - 48,536,235 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0355,133,418 - 55,201,844 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4344,457,151 - 44,525,602 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1344,353,522 - 44,421,639 (-)NCBI
Celera346,780,390 - 46,848,693 (-)NCBICelera
Cytogenetic Map3q21NCBI
FAP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21364,862,801 - 64,937,455 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan12B64,877,776 - 64,951,037 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v02B49,464,199 - 49,537,284 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.12B166,832,669 - 166,905,515 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2B166,832,963 - 166,904,950 (-)Ensemblpanpan1.1panPan2
FAP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1367,574,364 - 7,647,448 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl367,575,161 - 7,647,226 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha367,718,907 - 7,791,280 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0367,706,897 - 7,779,228 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl367,706,899 - 7,778,929 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1367,725,598 - 7,797,918 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0367,766,525 - 7,838,827 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0367,874,009 - 7,946,310 (-)NCBIUU_Cfam_GSD_1.0
Fap
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405303124,728,654 - 124,802,072 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493646916,817,232 - 16,888,773 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_00493646916,817,000 - 16,889,066 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
FAP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1568,830,730 - 68,902,379 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11568,831,281 - 68,902,416 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21576,323,040 - 76,394,182 (-)NCBISscrofa10.2Sscrofa10.2susScr3
FAP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11047,578,164 - 47,652,179 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1047,577,888 - 47,652,689 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666040151,875,647 - 151,947,663 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Fap
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247323,275,025 - 3,345,977 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247323,273,339 - 3,346,207 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


RefSeq Acc Id: ENSCLAT00000016292   ⟹   ENSCLAP00000016128
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544911,623,741 - 11,694,335 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000016293   ⟹   ENSCLAP00000016129
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544911,625,358 - 11,694,027 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000016294   ⟹   ENSCLAP00000016130
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495544911,625,358 - 11,694,027 (+)Ensembl
RefSeq Acc Id: XM_005393316   ⟹   XP_005393373
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495544911,623,838 - 11,694,256 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005393373 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000016128
  ENSCLAP00000016128.1
  ENSCLAP00000016129.1
  ENSCLAP00000016130.1
RefSeq Acc Id: XP_005393373   ⟸   XM_005393316
- UniProtKB: A0A8C2VIH4 (UniProtKB/TrEMBL),   A0A8C2VII1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000016129   ⟸   ENSCLAT00000016293
RefSeq Acc Id: ENSCLAP00000016128   ⟸   ENSCLAT00000016292
RefSeq Acc Id: ENSCLAP00000016130   ⟸   ENSCLAT00000016294

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000011098 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000016292 ENTREZGENE
  ENSCLAT00000016292.1 UniProtKB/TrEMBL
  ENSCLAT00000016293.1 UniProtKB/TrEMBL
  ENSCLAT00000016294.1 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.1820 UniProtKB/TrEMBL
  Dipeptidylpeptidase IV, N-terminal domain UniProtKB/TrEMBL
InterPro AB_hydrolase UniProtKB/TrEMBL
  Pept_S9_AS UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/TrEMBL
  Peptidase_S9B_N UniProtKB/TrEMBL
NCBI Gene Fap ENTREZGENE
PANTHER PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED UniProtKB/TrEMBL
  PTHR11731:SF136 UniProtKB/TrEMBL
Pfam DPPIV_N UniProtKB/TrEMBL
  Peptidase_S9 UniProtKB/TrEMBL
PROSITE PRO_ENDOPEP_SER UniProtKB/TrEMBL
Superfamily-SCOP DPP6 N-terminal domain-like UniProtKB/TrEMBL
  SSF53474 UniProtKB/TrEMBL
UniProt A0A8C2VIC4_CHILA UniProtKB/TrEMBL
  A0A8C2VIH4 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2VII1 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-16 Fap  fibroblast activation protein alpha    fibroblast activation protein, alpha  Symbol and/or name change 5135510 APPROVED