Ptpn5 (protein tyrosine phosphatase non-receptor type 5) - Rat Genome Database

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Gene: Ptpn5 (protein tyrosine phosphatase non-receptor type 5) Chinchilla lanigera
Analyze
Symbol: Ptpn5
Name: protein tyrosine phosphatase non-receptor type 5
RGD ID: 8724324
Description: ENCODES a protein that exhibits identical protein binding (ortholog); phosphotyrosine residue binding (ortholog); protein tyrosine phosphatase activity (ortholog); INVOLVED IN exploration behavior (ortholog); negative regulation of MAP kinase activity (ortholog); peptidyl-tyrosine dephosphorylation (ortholog); PARTICIPATES IN dopamine signaling pathway; ASSOCIATED WITH Alzheimer's disease (ortholog); Brain Hypoxia-Ischemia (ortholog); hypertrophic cardiomyopathy 12 (ortholog); FOUND IN axon (ortholog); neuronal cell body (ortholog); perikaryon (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: tyrosine-protein phosphatase non-receptor type 5
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541433,377,322 - 33,437,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541433,381,783 - 33,436,974 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Ptpn5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541433,377,322 - 33,437,118 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495541433,381,783 - 33,436,974 (-)NCBIChiLan1.0ChiLan1.0
PTPN5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381118,727,928 - 18,792,721 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1118,727,928 - 18,792,721 (-)EnsemblGRCh38hg38GRCh38
GRCh371118,749,475 - 18,814,268 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361118,706,051 - 18,769,965 (-)NCBINCBI36Build 36hg18NCBI36
Build 341118,706,052 - 18,769,874NCBI
Celera1118,885,312 - 18,948,746 (-)NCBICelera
Cytogenetic Map11p15.1NCBI
HuRef1118,434,330 - 18,498,764 (-)NCBIHuRef
CHM1_11118,748,812 - 18,813,611 (-)NCBICHM1_1
T2T-CHM13v2.01118,825,966 - 18,890,761 (-)NCBIT2T-CHM13v2.0
Ptpn5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39746,727,543 - 46,783,774 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl746,727,543 - 46,783,432 (-)EnsemblGRCm39 Ensembl
GRCm38747,077,795 - 47,134,026 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl747,077,795 - 47,133,684 (-)EnsemblGRCm38mm10GRCm38
MGSCv37754,333,168 - 54,389,054 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36746,945,824 - 47,001,706 (-)NCBIMGSCv36mm8
Celera742,560,280 - 42,616,180 (-)NCBICelera
Cytogenetic Map7B3NCBI
cM Map730.7NCBI
Ptpn5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81106,756,896 - 106,817,369 (-)NCBIGRCr8
mRatBN7.2197,620,638 - 97,681,186 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl197,620,642 - 97,679,882 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1103,010,604 - 103,069,779 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01111,482,589 - 111,541,753 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01104,768,970 - 104,828,192 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01103,197,918 - 103,258,309 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1103,197,915 - 103,256,823 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01104,263,139 - 104,321,833 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4197,629,192 - 97,643,225 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.1197,707,302 - 97,721,336 (-)NCBI
Celera191,865,125 - 91,880,882 (-)NCBICelera
Cytogenetic Map1q22NCBI
PTPN5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2921,037,528 - 21,101,209 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11120,997,916 - 21,061,597 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01118,758,285 - 18,822,845 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11118,672,360 - 18,737,167 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1118,673,366 - 18,711,885 (-)Ensemblpanpan1.1panPan2
PTPN5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12141,097,563 - 41,154,247 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2141,097,569 - 41,136,706 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2140,576,516 - 40,632,837 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02142,220,694 - 42,277,125 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2142,137,874 - 42,277,086 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12141,223,899 - 41,280,192 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02141,401,047 - 41,457,402 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02141,778,556 - 41,834,892 (-)NCBIUU_Cfam_GSD_1.0
Ptpn5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440494744,491,082 - 44,552,326 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936528525,769 - 586,327 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936528523,884 - 586,306 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PTPN5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl240,459,049 - 40,521,461 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1240,458,865 - 40,521,470 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2243,468,196 - 43,530,692 (+)NCBISscrofa10.2Sscrofa10.2susScr3
PTPN5
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1146,134,109 - 46,197,246 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl146,153,340 - 46,199,002 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_023666038143,475,470 - 143,539,473 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Ptpn5
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476610,147,840 - 10,204,238 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476610,147,859 - 10,204,657 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000024119   ⟹   ENSCLAP00000023893
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541433,377,322 - 33,437,118 (-)Ensembl
RefSeq Acc Id: XM_005380426   ⟹   XP_005380483
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541433,381,783 - 33,436,974 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013512076   ⟹   XP_013367530
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541433,381,783 - 33,436,974 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005380483 (Get FASTA)   NCBI Sequence Viewer  
  XP_013367530 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000023893
  ENSCLAP00000023893.1
RefSeq Acc Id: XP_005380483   ⟸   XM_005380426
- Peptide Label: isoform X1
- UniProtKB: A0A8C2W8T4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013367530   ⟸   XM_013512076
- Peptide Label: isoform X2
- Sequence:
Ensembl Acc Id: ENSCLAP00000023893   ⟸   ENSCLAT00000024119

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016396 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000024119 ENTREZGENE
  ENSCLAT00000024119.1 UniProtKB/TrEMBL
Gene3D-CATH 3.90.190.10 UniProtKB/TrEMBL
InterPro Prot-tyrosine_phosphatase-like UniProtKB/TrEMBL
  PTP_cat UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/TrEMBL
  Tyr_Pase_dom UniProtKB/TrEMBL
  Tyr_Pase_KIM-con UniProtKB/TrEMBL
  Tyr_Pase_rcpt_R/non-rcpt_5 UniProtKB/TrEMBL
NCBI Gene Ptpn5 ENTREZGENE
PANTHER PTHR46198 UniProtKB/TrEMBL
  TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 5 UniProtKB/TrEMBL
Pfam Y_phosphatase UniProtKB/TrEMBL
PIRSF PTPRR UniProtKB/TrEMBL
PRINTS KIMPTPASE UniProtKB/TrEMBL
  PRTYPHPHTASE UniProtKB/TrEMBL
PROSITE TYR_PHOSPHATASE_1 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/TrEMBL
SMART PTPc UniProtKB/TrEMBL
  PTPc_motif UniProtKB/TrEMBL
Superfamily-SCOP SSF52799 UniProtKB/TrEMBL
UniProt A0A8C2W8T4 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2019-02-19 Ptpn5  protein tyrosine phosphatase non-receptor type 5    protein tyrosine phosphatase, non-receptor type 5  Symbol and/or name change 5135510 APPROVED
2016-08-03 Ptpn5  protein tyrosine phosphatase, non-receptor type 5    protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)  Symbol and/or name change 5135510 APPROVED