Fgl2 (fibrinogen like 2) - Rat Genome Database

Name: Fgl2
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

Gene: Fgl2 (fibrinogen like 2) Chinchilla lanigera

Analyze

Symbol:

Fgl2

Name:

fibrinogen like 2

RGD ID:

8717850

Description:

ENCODES a protein that exhibits peptidase activator activity (ortholog); INVOLVED IN negative regulation of defense response to virus (ortholog); negative regulation of dendritic cell antigen processing and presentation (ortholog); negative regulation of macrophage antigen processing and presentation (ortholog); ASSOCIATED WITH allergic contact dermatitis (ortholog); autoimmune glomerulonephritis (ortholog); Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB (ortholog); FOUND IN cell surface (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

fibrinogen-like 2; fibroleukin

RGD Orthologs

Alliance Genes

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	FGL2 (fibrinogen like 2)	NCBI	Ortholog
Mus musculus (house mouse):	Fgl2 (fibrinogen-like protein 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Rattus norvegicus (Norway rat):	Fgl2 (fibrinogen-like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	FGL2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	FGL2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Fgl2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	FGL2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	FGL2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Fgl2 (fibrinogen like 2)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	7,899,309 - 7,902,722 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955410	7,899,263 - 7,903,499 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

allergic contact dermatitis (ISO)

autoimmune glomerulonephritis (ISO)

Chromosome 7q11.23 Deletion Syndrome, Distal, 1.2-MB (ISO)

COVID-19 (ISO)

Experimental Autoimmune Myocarditis (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

pleomorphic xanthoastrocytoma (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

negative regulation of defense response to virus (ISO)

negative regulation of dendritic cell antigen processing and presentation (ISO)

negative regulation of macrophage antigen processing and presentation (ISO)

negative regulation of memory T cell differentiation (ISO)

T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell (ISO)

Cellular Component

cell surface (ISO)

Molecular Function

peptidase activator activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Additional References at PubMed

PMID:30032202

Genomics

Comparative Map Data

Fgl2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955410	7,899,309 - 7,902,722 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955410	7,899,263 - 7,903,499 (+)	NCBI	ChiLan1.0	ChiLan1.0

FGL2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	7	77,193,369 - 77,199,819 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	7	77,193,369 - 77,199,848 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	7	76,822,686 - 76,829,136 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	7	76,660,624 - 76,667,086 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	7	76,470,142 - 76,473,795	NCBI
Celera	7	71,523,351 - 71,529,814 (-)	NCBI		Celera
Cytogenetic Map	7	q11.23	NCBI
HuRef	7	71,425,321 - 71,431,783 (-)	NCBI		HuRef
CHM1_1	7	76,752,975 - 76,759,437 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	7	78,444,483 - 78,450,933 (-)	NCBI		T2T-CHM13v2.0
CRA_TCAGchr7v2	7	76,155,751 - 76,162,213 (-)	NCBI

Fgl2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	5	21,577,671 - 21,583,384 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	5	21,577,640 - 21,583,372 (+)	Ensembl		GRCm39 Ensembl
GRCm38	5	21,372,673 - 21,378,386 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	5	21,372,642 - 21,378,374 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	5	20,878,491 - 20,884,204 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	5	20,884,527 - 20,890,197 (+)	NCBI		MGSCv36	mm8
Celera	5	18,336,281 - 18,342,004 (+)	NCBI		Celera
Cytogenetic Map	5	A3	NCBI
cM Map	5	9.83	NCBI

Fgl2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	4	14,602,762 - 14,608,405 (-)	NCBI		GRCr8
mRatBN7.2	4	13,710,566 - 13,716,207 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	4	13,710,575 - 13,716,207 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	4	18,837,881 - 18,843,545 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	4	14,647,254 - 14,652,909 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	4	13,023,530 - 13,029,194 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	4	10,323,598 - 10,329,241 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	4	10,323,607 - 10,329,241 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	4	10,315,666 - 10,321,309 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	4	9,176,333 - 9,181,976 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	4	9,178,562 - 9,181,975 (-)	NCBI
Celera	4	9,274,110 - 9,279,753 (-)	NCBI		Celera
Cytogenetic Map	4	q11	NCBI

FGL2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	6	95,044,215 - 95,109,732 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	7	143,308,854 - 143,374,372 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	7	69,114,082 - 69,120,575 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	7	82,926,035 - 82,932,550 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	7	82,926,266 - 82,932,550 (-)	Ensembl	panpan1.1		panPan2

FGL2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	17,328,794 - 17,335,429 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	17,331,780 - 17,335,401 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	16,987,483 - 16,994,083 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	17,648,480 - 17,655,066 (-)	NCBI		ROS_Cfam_1.0
UMICH_Zoey_3.1	18	17,399,538 - 17,406,132 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	17,338,550 - 17,345,153 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	17,607,841 - 17,614,446 (-)	NCBI		UU_Cfam_GSD_1.0

Fgl2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405118	59,496,212 - 59,501,673 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936479	20,619,931 - 20,652,981 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936479	20,619,955 - 20,625,416 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

FGL2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	9	102,868,802 - 102,875,576 (+)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	9	102,869,044 - 102,875,564 (+)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	9	113,105,965 - 113,115,736 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3
Pig Cytomap	9	q16-q17	NCBI

FGL2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	21	71,735,486 - 71,741,951 (+)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	21	71,735,253 - 71,742,954 (+)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666042	32,255,115 - 32,263,210 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Fgl2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624739	26,503,965 - 26,507,305 (-)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624739	26,501,149 - 26,507,305 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005377557	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01010726	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCE01075859	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDF01281505	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

ENSCLAT00000006969 ⟹ ENSCLAP00000006857

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955410	7,899,309 - 7,902,722 (+)	Ensembl

RefSeq Acc Id:

XM_005377557 ⟹ XP_005377614

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955410	7,899,263 - 7,903,499 (+)	NCBI

Sequence:

show sequence

ACGCCCCGCCCTTCCTGGGAACGCGCGCGGCCGCGGCCTGGCTATTAAAGCGCGCGGGCGCCCG
CCGGCCGCAGAGATGCAGCTCCCCGTCTGGTGCTGCCTGGGCGCCGCGCTCCTCGCCGCCCCGG
GGTGGGCGGCGGCGGCCGGGGCCGGGGCGGCGAGCCCGGAGCCGGGCGATGGCGCCGCGGGCCC
CGCGTGCGCCGCGCGGCTGGAGCTGGAGCCGGGGCCGGGCGGGCGCTGCGGCGGAGGCCAGGCC
GGCGAGTGCGCGCTGCAGGTGCGCCTGCCCGCGCTCACCATCCCGCTGCCCGCGCCGCTCGGCC
GGCTCGAGGAGGTGTTCAGGGAGGTCCAGACCCTCAAGGACGCCGTGGCCAGCCTGCAGAAGTC
CTGCCAGGACTGCAGGCTGCAGGCCGACGAGCACCGGGACCCCCCGCTGTCCCCCAGCCCGGGA
CCCCCGGGGGAGAACGGCGACCTCCGCGTGCAGGACCTGGAGAGCCAGGTGCACGAGCTGTCGT
CGGAGCTAAAGGGCGCCCGCGAGGAGATCGGCGCGCTCCACCGGCGCCTGGAGAAGCTGAGTCT
CGTAAATATGAACAACATCGAGAACTACGTTGACAGCAAAGTCGCCAATCTGACATTTGTGGTC
AACAGTTTGGACGGGAAGTGCTCGTCCCAGTGCCCCAGCCAAGAACAAATCCAGTCCCGCCCAG
TTCAACATCTGATATACAAAGACTGCTCTGACTACTACGTAATAGGCAGAAGAAGCAGCGAGAC
CTACAGAGTTACACCTGATCCCAAAAACAGCAGCTTCGAGGTGCCCTGCGACATGGAGAGGCTG
GGCGGAGGCTGGACGGTGCTGCAGGCGCGGCTGGATGGCAGCACCAACTTCTCCAGGAACTGGC
GCGACTACAAGGAAGGCTTTGGCAACCTCCACCGGGAGTTCTGGCTGGGAAACGATAAGATTCA
CCTTCTGACCAAGAGCAAGGAGATGATCCTGAGAATAGACCTCGAGGACTTTGAGGGTGTCAAG
CTGTACGCGGTGTATGACCACTTTTACGTGGCGAATGAGTTTCTCAAGTACCGTCTGCACGTTG
GGAGCTACAGCGGCACAGCTGGGGACGCCCTGCGTTTCAGTAAACATTACAACCACGACCTGAA
GTTCTTCACCACCCCGGACAGAGACAACGACCGCTATCCCTCGGGGAACTGCGGGCGCTACTAC
AGTTCGGGCTGGTGGTTTGATGCTTGTCTTTCAGCCAATTTAAATGGCAAATACTACCACCAGA
AGTACAGAGGTGTCCGTAATGGGATTTTCTGGGGCACCTGGCCTGGGGTGAGTGAGGCGCAGCC
TAATGGCTACAAGTCCTCCTTCAAAAGGGTCACGATGATGATTAGACCCAAGAACTTTAAGCCA
TAACAGCTGGGCTCATTTCACCAGGCATTTATATCTAATAGCGTGAGTCCTGCCTTTAGCACTT
TGGGGTGTGCCTTCTTTCGGATCTCTTTTCCACAGCCAACACATTATCTCTGAGCATAGGTTCT
TATGCTATATAGCATTTGGAATAAAGCTGAAAATATGCATTTTAAAGAGTCCTTTGCTGCTGTT
AACCAAGGAATGCATGGAAGCATTGGAAATCTTAAAATAGATTCTATTTATGTCTTTTAATTTC
TACTAATTAGAAATGTCTTTATTATTTGTATTACTTTCTATTATAAAAATGGCTTATTCAGCAA
ACTAGATGCTACACAAAGCAATCTCCACTTGGGCTGTGGCTGAACGTGCAAATTTGAAAATATA
TCACTCTTTTCAGGCTAGAAATGTTTATTTGTATATGTGTCCCTTAATACTGCAATGTTTGTTC
TAAGATAAACTCACTCACTTTATGGCGTTTATTTTGGGCCAGGAAGACCTTACAGTATCTTACT
TTCCAAGTAAAGGGAAATCATATATGTAATTAAACCTGTTCATGTAATACTCATGAAATCTAAA
ATATGGCATTTCCCTGCTGTTTTAATTTGGTACATATTTAATACTGTAAAATGAGGTATCTCAA
TGTCACCAACAAAACATTCAAAAAATAATGTAACTTTGAAAACTTTGGTTTAAAGTGCTTTGTT
CAGGGCCTATAACTTTTCAGAAGTCTGATCGTAAAAACTGCTTTAACATACAAATTATCTTCCT
CTGTTCTGCTTA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005377614	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSCLAP00000006857.1

RefSeq Acc Id:

XP_005377614 ⟸ XM_005377557

- Sequence:

show sequence

MQLPVWCCLGAALLAAPGWAAAAGAGAASPEPGDGAAGPACAARLELEPGPGGRCGGGQAGECA
LQVRLPALTIPLPAPLGRLEEVFREVQTLKDAVASLQKSCQDCRLQADEHRDPPLSPSPGPPGE
NGDLRVQDLESQVHELSSELKGAREEIGALHRRLEKLSLVNMNNIENYVDSKVANLTFVVNSLD
GKCSSQCPSQEQIQSRPVQHLIYKDCSDYYVIGRRSSETYRVTPDPKNSSFEVPCDMERLGGGW
TVLQARLDGSTNFSRNWRDYKEGFGNLHREFWLGNDKIHLLTKSKEMILRIDLEDFEGVKLYAV
YDHFYVANEFLKYRLHVGSYSGTAGDALRFSKHYNHDLKFFTTPDRDNDRYPSGNCGRYYSSGW
WFDACLSANLNGKYYHQKYRGVRNGIFWGTWPGVSEAQPNGYKSSFKRVTMMIRPKNFKP

hide sequence

RefSeq Acc Id:

ENSCLAP00000006857 ⟸ ENSCLAT00000006969

Protein Domains

Fibrinogen C-terminal

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000004828	Ensembl, UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000006969.1	UniProtKB/TrEMBL
Gene3D-CATH	3.90.215.10	UniProtKB/TrEMBL
InterPro	Fibrinogen-like_C	UniProtKB/TrEMBL
	Fibrinogen_a/b/g_C_1	UniProtKB/TrEMBL
	Fibrinogen_a/b/g_C_dom	UniProtKB/TrEMBL
	Fibrinogen_CS	UniProtKB/TrEMBL
NCBI Gene	Fgl2	ENTREZGENE
PANTHER	FIBRINOGEN/TENASCIN/ANGIOPOEITIN	UniProtKB/TrEMBL
	PTHR19143:SF189	UniProtKB/TrEMBL
Pfam	Fibrinogen_C	UniProtKB/TrEMBL
PROSITE	FIBRINOGEN_C_1	UniProtKB/TrEMBL
	FIBRINOGEN_C_2	UniProtKB/TrEMBL
SMART	FBG	UniProtKB/TrEMBL
Superfamily-SCOP	SSF56496	UniProtKB/TrEMBL
UniProt	A0A8C2V2N4_CHILA	UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Fgl2	fibrinogen like 2		fibrinogen-like 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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