Adora2b (adenosine A2b receptor) - Rat Genome Database

Name: Adora2b
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

	Submit Data \| Help \| Video Tutorials \| News \| Publications \| FTP Download \| REST API \| Citing RGD \| Contact
	Search RGD Grant Resources Citing RGD About Us Contact Us Genes QTLs Strains Markers Genome Information Ontologies Cell Lines References FTP Download Submit Data OntoMate (Literature Search) JBrowse (Genome Browser) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) RatMine GViewer (Genome Viewer) Overgo Probe Designer ACP Haplotyper Genome Scanner Aging & Age-Related Disease Cancer Cardiovascular Disease COVID-19 Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease Find Models new Genetic Models Autism Models PhenoMiner (Quantitative Phenotypes) Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes GERRC (Gene Editing Rat Resource Center) Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive Pathways Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Poster Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
	Advanced Search (OLGA)

Gene: Adora2b (adenosine A2b receptor) Chinchilla lanigera

Analyze

Symbol:

Adora2b

Name:

adenosine A2b receptor

RGD ID:

8717272

Description:

ENCODES a protein that exhibits G protein-coupled receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); cellular response to extracellular stimulus (ortholog); negative regulation of cell population proliferation (ortholog); PARTICIPATES IN adenosine signaling pathway; ASSOCIATED WITH Neoplasm Metastasis (ortholog); Reperfusion Injury (ortholog); Sepsis (ortholog); FOUND IN cell surface (ortholog); glutamatergic synapse (ortholog); plasma membrane (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Also known as:

adenosine receptor A2b

RGD Orthologs

Human

Mouse

Rat

Bonobo

Dog

Squirrel

Pig

Green Monkey

Naked Mole-Rat

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	1,342,271 - 1,363,138 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955467	1,342,271 - 1,363,149 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

Neoplasm Metastasis (ISO)

Reperfusion Injury (ISO)

Sepsis (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (ISO)

cellular response to extracellular stimulus (ISO)

negative regulation of cell population proliferation (ISO)

negative regulation of collagen biosynthetic process (ISO)

obsolete positive regulation of blood vessel diameter (ISO)

positive regulation of cAMP-mediated signaling (ISO)

positive regulation of catecholamine secretion (ISO)

positive regulation of cell population proliferation (ISO)

positive regulation of cGMP-mediated signaling (ISO)

positive regulation of chemokine production (ISO)

positive regulation of chronic inflammatory response to non-antigenic stimulus (ISO)

positive regulation of endothelial cell migration (ISO)

positive regulation of endothelial cell proliferation (ISO)

positive regulation of guanylate cyclase activity (ISO)

positive regulation of interleukin-6 production (ISO)

positive regulation of mast cell degranulation (ISO)

positive regulation of norepinephrine secretion (ISO)

positive regulation of steroid biosynthetic process (ISO)

positive regulation of vascular endothelial growth factor production (ISO)

regulation of glucose metabolic process (ISO)

regulation of synaptic vesicle exocytosis (ISO)

relaxation of vascular associated smooth muscle (ISO)

response to angiotensin (ISO)

Cellular Component

cell surface (ISO)

glutamatergic synapse (ISO)

plasma membrane (ISO)

Schaffer collateral - CA1 synapse (ISO)

synapse (ISO)

Molecular Function

G protein-coupled receptor activity (ISO)

protein binding (ISO)

Molecular Pathway Annotations Click to see Annotation Detail View

adenosine signaling pathway (ISO)

References

References - curated


1.	Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations

Genomics

Comparative Map Data

Adora2b
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955467	1,342,271 - 1,363,138 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955467	1,342,271 - 1,363,149 (+)	NCBI	ChiLan1.0	ChiLan1.0

ADORA2B
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38.p13 Ensembl	17	15,944,917 - 15,975,746 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh38	17	15,927,782 - 15,975,746 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh37	17	15,848,444 - 15,879,210 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
GRCh37	17	15,848,231 - 15,879,210 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	15,788,956 - 15,819,935 (+)	NCBI	NCBI36		hg18	NCBI36
Build 34	17	15,788,955 - 15,819,935	NCBI
Celera	17	15,751,524 - 15,782,216 (+)	NCBI
Cytogenetic Map	17	p12	NCBI
HuRef	17	15,715,812 - 15,746,515 (+)	NCBI		HuRef
CHM1_1	17	15,856,999 - 15,887,687 (+)	NCBI		CHM1_1

Adora2b
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	62,139,810 - 62,157,278 (+)	NCBI	GRCm39		mm39
GRCm38	11	62,248,984 - 62,266,452 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	62,248,984 - 62,266,453 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	62,062,486 - 62,079,954 (+)	NCBI	GRCm37		mm9	NCBIm37
MGSCv36	11	62,065,179 - 62,082,647 (+)	NCBI			mm8
Celera	11	68,108,085 - 68,109,506 (+)	NCBI		Celera
Cytogenetic Map	11	B2	NCBI

Adora2b
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	46,940,394 - 46,956,772 (+)	NCBI
Rnor_6.0 Ensembl	10	48,569,555 - 48,586,365 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_6.0	10	48,569,563 - 48,586,366 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_5.0	10	48,358,068 - 48,374,871 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	48,421,592 - 48,437,967 (+)	NCBI	RGSC3.4		rn4	RGSC3.4
RGSC_v3.1	10	48,435,217 - 48,451,589 (+)	NCBI
Celera	10	46,186,295 - 46,202,681 (+)	NCBI		Celera
Cytogenetic Map	10	q23	NCBI

ADORA2B
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Mhudiblu_PPA_v0	17	34,849,466 - 34,880,088 (+)	NCBI	Mhudiblu_PPA_v0		panPan3

ADORA2B
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	5	39,884,375 - 39,908,214 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1

Adora2b
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
SpeTri2.0	NW_004936821	583,463 - 608,189 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

ADORA2B
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	59,393,220 - 59,449,692 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	59,431,834 - 59,449,701 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1

ADORA2B
(Chlorocebus sabaeus - African green monkey)

Vervet Assembly	Chr	Position (strand)	Source	Genome Browsers
Vervet Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	15,682,669 - 15,712,079 (-)	NCBI
ChlSab1.1 Ensembl	16	15,683,077 - 15,711,858 (-)	Ensembl

Adora2b
(Heterocephalus glaber - naked mole-rat)

Molerat Assembly	Chr	Position (strand)	Source	Genome Browsers
Molerat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624877	4,421,307 - 4,447,574 (-)	NCBI

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005399305	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01051262	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01175337	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSCLAT00000008868 ⟹ ENSCLAP00000008740

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0 Ensembl	NW_004955467	1,342,271 - 1,363,138 (+)	Ensembl

RefSeq Acc Id:

XM_005399305 ⟹ XP_005399362

RefSeq Status:

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955467	1,342,271 - 1,363,149 (+)	NCBI

Sequence:

show sequence

GCCGAGGCGCGGCGCGTGGTCTGCGGCCATGCCCGGCGGGTGCCCCGCGGTTGTCCCGCGTCTG
GCGCGAGGCTGGTAGGTGACCCGGGCCCGGCTGGCCGGCCATGCCGCTGGAGACTGAGGACGCG
CTGTACGTGGCGCTGGAGCTGGCCATCGCCGTGCTGTCGGTGACTGGCAACGTGCTGGTGTGCG
CGGCGGTGGGCTCGTCCAGCGCGCTGCAGACGCCCACCAACTACTTCCTGGTGTCCCTGGCTGC
GGCGGACGTGGCCGTGGGGCTGTTCGCCATCCCCTTTGCCATCACCATCAGCCTGGGCTTCTGC
ACGGACTTCCACAGCTGCCTCTTCCTCGCCTGCTTCGTGCTCGTGCTCACGCAGAGCTCCATCT
TCAGCCTCTTGGCCGTGGCGGTCGACAGGTACCTGGCCGTCCGCGTCCCGCTCAGGTATAAAAG
TTTGGTCACTGGGAGCCGAGCAAGAGGGGTCATTGCTGTCCTGTGGGTCCTTGCCTTTGGCATT
GGACTGACCCCATTCCTGGGGTGGAACAGTAAAGACAGTGCCACCAACAACTGCACAGAGCCCT
GGGATGGAGCCACAAACGAAAGCTGCTGCCTTGTGAAGTGTCTCTTTGAGAATGTGGTCCCCAT
GAGCTACATGGTGTATTTCAATTTCTTTGGGTGTGTCCTGCCCCCACTGCTCATAATGCTGGTG
ATCTACATCAAGATCTTCATGGTGGCCTGCAGGCAGCTTCAGCGTACTGAGCTGATGCACCACT
CGAGGACCACCCTCCAGCGGGAGATCCACGCGGCCAAGTCACTGGCTATGATCATGGGGATTTT
TGCTCTGTGCTGGCTTCCAGTACATGCTATCAACTGTGTCACTCTTTTTCAGCCATCTCTAGCT
AAGGATAAGCCCAAGTGGGCAATGAACACAGCCATTCTCTTGTCACATGCCAATTCAGTTGTCA
ATCCCATTGTTTATGCTTACAGGAACCGAGATTTCCGCTATACTTTTCACAAAATCATCTCCAG
GTATGTTCTCTGCCAGACAGATATCAAGAGTGGGAGTGGGCAGACTGGAATACAGCCTGCTTTC
AACGTGGGATTATGACCTAGGCTCTGGCCTCTTGGAGAGAAGGCACAGATCCAAAGTAAACAAC
GGGACAGGATATGACTGGCTGATTCTCACTGTGAAAAACAGCCACAGCTCACAAGCATATGGCT
GCCTCTTTTGAGTACTTGCCTAAAGTTACCATGTATCCAGCTGATATCGGTATGCTATTAGTAG
ATTCCACGGATTGACAAATATATTTACGGTCTTATTTGCCTGCTTTTAGTGTGTGGATGATGCT
GACAGCTTGAATGGATTCTAAAACTTTTGAAGAGTCTGCCTCACTCATGGTTGAAAATGACTGA
AACTATTTACTGTGAAATACCCTGAACTATTATATTGCAAATATTTTTAACATAGAGGCAGTAG
AAAAATAAAAATTGGCTGTACTAATCTATACTTGTTCTCAGGAGGGTAATCAAGAATACTGAAG
TATGATTCTTCAAACAAGAAAGGGCCCTATTAATTTAGGGAATGGTATTCTCCCAAGTTCTTAA
GTAGGATTCTCATCAAGTAACAACTGTACGTTCTGTTCTTTTCCATATACAAAACATTACTTAG
AAGAAGAAATTGGAAAAATGGGATCCATCCTTACAGGATTCTCCCTTTTAGAGCTAGGTACTGA
ATTGTGCTTCTCTCCCAAGTTCAACTTTGGTGAAGTTGTTGGAACCCAAAGTGTGAAAATTTTA
CTAAGCAAAATTATAAAACTGTGTATATTGTATGAAATAAATCTTTTTAAAAAAACAAA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005399362	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

XP_005399362 ⟸ XM_005399305

- Sequence:

show sequence

MPLETEDALYVALELAIAVLSVTGNVLVCAAVGSSSALQTPTNYFLVSLAAADVAVGLFAIPFA
ITISLGFCTDFHSCLFLACFVLVLTQSSIFSLLAVAVDRYLAVRVPLRYKSLVTGSRARGVIAV
LWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGATNESCCLVKCLFENVVPMSYMVYFNFFGCVL
PPLLIMLVIYIKIFMVACRQLQRTELMHHSRTTLQREIHAAKSLAMIMGIFALCWLPVHAINCV
TLFQPSLAKDKPKWAMNTAILLSHANSVVNPIVYAYRNRDFRYTFHKIISRYVLCQTDIKSGSG
QTGIQPAFNVGL

hide sequence

RefSeq Acc Id:

ENSCLAP00000008740 ⟸ ENSCLAT00000008868

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000006111	Ensembl, ENTREZGENE
Ensembl Protein	ENSCLAP00000008740	ENTREZGENE
Ensembl Transcript	ENSCLAT00000008868	ENTREZGENE
NCBI Gene	Adora2b	ENTREZGENE

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Imported Disease Annotations - CTD

Imported Annotations - SMPDB