Dnmt1 (DNA methyltransferase 1) - Rat Genome Database

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Gene: Dnmt1 (DNA methyltransferase 1) Chinchilla lanigera
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Symbol: Dnmt1
Name: DNA methyltransferase 1
RGD ID: 8716438
Description: ENCODES a protein that exhibits chromatin binding (ortholog); DNA (cytosine-5-)-methyltransferase activity (ortholog); DNA binding (ortholog); INVOLVED IN aging (ortholog); brain development (ortholog); cellular response to amino acid stimulus (ortholog); PARTICIPATES IN DNA modification pathway; glycine N-methyltransferase deficiency pathway; homocysteine metabolic pathway; ASSOCIATED WITH acute myeloid leukemia (ortholog); adenocarcinoma (ortholog); Alcoholic Fatty Liver (ortholog); FOUND IN cytoplasm (ortholog); female germ cell nucleus (ortholog); germ cell nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: DNA (cytosine-5)-methyltransferase 1; DNA (cytosine-5-)-methyltransferase 1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,465,480 - 1,505,462 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,465,529 - 1,505,379 (-)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute myeloid leukemia  (ISO)
adenocarcinoma  (ISO)
Alcoholic Fatty Liver  (ISO)
alopecia areata  (ISO)
anxiety disorder  (ISO)
asthma  (ISO)
Ataxia  (ISO)
autoimmune disease  (ISO)
autosomal dominant cerebellar ataxia, deafness and narcolepsy  (ISO)
Beckwith-Wiedemann syndrome  (ISO)
Binge Drinking  (ISO)
Brain Injuries  (ISO)
Breast Neoplasms  (ISO)
bronchiolo-alveolar adenocarcinoma  (ISO)
Carcinogenesis  (ISO)
carcinoma  (ISO)
cardiomyopathy  (ISO)
cerebellar ataxia  (ISO)
Charcot-Marie-Tooth disease  (ISO)
choline deficiency disease  (ISO)
chronic myeloid leukemia  (ISO)
clear cell renal cell carcinoma  (ISO)
Colonic Neoplasms  (ISO)
Colorectal Neoplasms  (ISO)
congenital heart disease  (ISO)
congestive heart failure  (ISO)
dementia  (ISO)
Endometrial Neoplasms  (ISO)
Endometrioid Carcinomas  (ISO)
endometriosis  (ISO)
endometriosis of uterus  (ISO)
Experimental Arthritis  (ISO)
Fetal Growth Retardation  (ISO)
Graves' disease  (ISO)
Hearing Loss  (ISO)
hepatocellular carcinoma  (ISO)
hereditary sensory neuropathy  (ISO)
hereditary sensory neuropathy type 1E  (ISO)
Hyperalgesia  (ISO)
hypertrophic cardiomyopathy  (ISO)
liver cirrhosis  (ISO)
lung cancer  (ISO)
lung carcinoma  (ISO)
lung non-small cell carcinoma  (ISO)
medulloblastoma  (ISO)
meningioma  (ISO)
middle cerebral artery infarction  (ISO)
mucoepidermoid carcinoma  (ISO)
myelodysplastic syndrome  (ISO)
Neoplasm Invasiveness  (ISO)
Oral Lichen Planus  (ISO)
Ovarian Neoplasms  (ISO)
pancreatic ductal carcinoma  (ISO)
Pancreatic Intraepithelial Neoplasia  (ISO)
Peritoneal Fibrosis  (ISO)
Pituitary Stalk Interruption Syndrome  (ISO)
prostate adenocarcinoma  (ISO)
prostate cancer  (ISO)
prostate carcinoma in situ  (ISO)
Prostatic Neoplasms  (ISO)
rheumatoid arthritis  (ISO)
schizophrenia  (ISO)
sleep disorder  (ISO)
spastic ataxia  (ISO)
Spastic Paraparesis  (ISO)
Stomach Neoplasms  (ISO)
systemic lupus erythematosus  (ISO)
type 2 diabetes mellitus  (ISO)
urinary bladder cancer  (ISO)
Uterine Cervical Neoplasms  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
brain development  (ISO)
cellular response to amino acid stimulus  (ISO)
cellular response to bisphenol A  (ISO)
cellular response to lead ion  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
DNA hypermethylation  (ISO)
DNA methylation  (ISO)
DNA methylation involved in embryo development  (ISO)
DNA methylation on cytosine  (ISO)
DNA methylation on cytosine within a CG sequence  (ISO)
DNA methylation-dependent heterochromatin formation  (ISO)
DNA-templated transcription  (ISO)
maintenance of DNA methylation  (ISO)
negative regulation of DNA-templated transcription  (ISO)
negative regulation of gene expression  (ISO)
negative regulation of histone H3-K9 methylation  (ISO)
negative regulation of transcription by RNA polymerase II  (ISO)
negative regulation of vascular associated smooth muscle cell apoptotic process  (ISO)
negative regulation of vascular associated smooth muscle cell differentiation involved in phenotypic switching  (ISO)
neuron differentiation  (ISO)
positive regulation of DNA methylation-dependent heterochromatin formation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of histone H3-K4 methylation  (ISO)
positive regulation of vascular associated smooth muscle cell proliferation  (ISO)
Ras protein signal transduction  (ISO)
regulation of cell population proliferation  (ISO)
regulation of gene expression  (ISO)
response to activity  (ISO)
response to caffeine  (ISO)
response to estradiol  (ISO)
response to ethanol  (ISO)
response to heat  (ISO)
response to ionizing radiation  (ISO)
response to lead ion  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to organic substance  (ISO)
response to testosterone  (ISO)
response to toxic substance  (ISO)
response to vitamin A  (ISO)
response to xenobiotic stimulus  (ISO)
S-adenosylmethionine metabolic process  (ISO)

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISS annotations to Chinchilla, Squirrel, Bonobo and/or Dog genes from Human gene annotations
2. OMIM Disease Annotation Pipeline OMIM Disease Annotation Pipeline

Genomics

Comparative Map Data
Dnmt1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554951,465,480 - 1,505,462 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554951,465,529 - 1,505,379 (-)NCBIChiLan1.0ChiLan1.0
DNMT1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381910,133,346 - 10,194,953 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1910,133,342 - 10,231,286 (-)EnsemblGRCh38hg38GRCh38
GRCh371910,244,022 - 10,305,629 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361910,105,022 - 10,166,811 (-)NCBINCBI36hg18NCBI36
Build 341910,105,022 - 10,166,811NCBI
Celera1910,139,454 - 10,201,147 (-)NCBI
Cytogenetic Map19p13.2NCBI
HuRef199,824,670 - 9,886,268 (-)NCBIHuRef
CHM1_11910,244,307 - 10,306,021 (-)NCBICHM1_1
T2T-CHM13v2.01910,259,569 - 10,321,116 (-)NCBI
Dnmt1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39920,818,501 - 20,871,184 (-)NCBIGRCm39mm39
GRCm39 Ensembl920,818,505 - 20,871,184 (-)Ensembl
GRCm38920,907,206 - 20,959,888 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl920,907,209 - 20,959,888 (-)EnsemblGRCm38mm10GRCm38
MGSCv37920,711,653 - 20,757,317 (-)NCBIGRCm37mm9NCBIm37
MGSCv36920,657,611 - 20,703,267 (-)NCBImm8
Celera918,175,907 - 18,221,569 (-)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.66NCBI
Dnmt1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2819,440,611 - 19,486,659 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl819,440,611 - 19,486,659 (-)Ensembl
Rnor_6.0821,922,515 - 21,968,495 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl821,922,515 - 21,968,495 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0821,978,830 - 22,024,656 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4819,926,995 - 19,973,256 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1819,927,666 - 19,973,220 (-)NCBI
Celera820,835,612 - 20,881,380 (-)NCBICelera
Cytogenetic Map8q13NCBI
DNMT1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11910,342,478 - 10,390,397 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1910,342,478 - 10,406,972 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0199,681,847 - 9,745,334 (-)NCBIMhudiblu_PPA_v0panPan3
DNMT1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12050,872,213 - 50,928,352 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2050,879,527 - 50,928,029 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2050,741,748 - 50,797,884 (+)NCBI
ROS_Cfam_1.02051,393,895 - 51,450,128 (+)NCBI
ROS_Cfam_1.0 Ensembl2051,401,720 - 51,450,127 (+)Ensembl
UMICH_Zoey_3.12050,599,735 - 50,657,798 (+)NCBI
UNSW_CanFamBas_1.02051,028,945 - 51,085,072 (+)NCBI
UU_Cfam_GSD_1.02051,269,676 - 51,325,956 (+)NCBI
Dnmt1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118209,789,213 - 209,834,531 (+)NCBI
SpeTri2.0NW_004936659520,181 - 565,496 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DNMT1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl268,981,566 - 69,029,844 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1268,981,564 - 69,040,364 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2269,309,511 - 69,357,838 (-)NCBISscrofa10.2Sscrofa10.2susScr3
DNMT1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.169,199,006 - 9,263,890 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl69,199,003 - 9,263,607 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366607410,795,260 - 10,857,063 (+)NCBIVero_WHO_p1.0
Dnmt1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248282,315,251 - 2,358,711 (-)EnsemblHetGla_female_1.0hetGla2
HetGla 1.0NW_0046248282,316,042 - 2,358,866 (-)NCBIHetGla_female_1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000014001   ⟹   ENSCLAP00000013845
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554951,465,480 - 1,505,462 (-)Ensembl
RefSeq Acc Id: ENSCLAT00000014002   ⟹   ENSCLAP00000013846
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_0049554951,465,480 - 1,505,462 (-)Ensembl
RefSeq Acc Id: XM_005405582   ⟹   XP_005405639
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,465,529 - 1,505,379 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005405583   ⟹   XP_005405640
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,465,529 - 1,496,803 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505316   ⟹   XP_013360770
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,465,529 - 1,497,704 (-)NCBI
Sequence:
RefSeq Acc Id: XM_013505317   ⟹   XP_013360771
RefSeq Status:
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_0049554951,465,529 - 1,504,933 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005405639 (Get FASTA)   NCBI Sequence Viewer  
  XP_005405640 (Get FASTA)   NCBI Sequence Viewer  
  XP_013360770 (Get FASTA)   NCBI Sequence Viewer  
  XP_013360771 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005405639   ⟸   XM_005405582
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005405640   ⟸   XM_005405583
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013360771   ⟸   XM_013505317
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013360770   ⟸   XM_013505316
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCLAP00000013845   ⟸   ENSCLAT00000014001
RefSeq Acc Id: ENSCLAP00000013846   ⟸   ENSCLAT00000014002
Protein Domains
BAH   CXXC-type   DMAP1-binding


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000009575 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCLAP00000013845 UniProtKB/TrEMBL
  ENSCLAP00000013846 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000014001 UniProtKB/TrEMBL
  ENSCLAT00000014002 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.490 UniProtKB/TrEMBL
  3.40.50.150 UniProtKB/TrEMBL
InterPro BAH_dom UniProtKB/TrEMBL
  BAH_sf UniProtKB/TrEMBL
  C5_DNA_meth_AS UniProtKB/TrEMBL
  C5_MeTfrase UniProtKB/TrEMBL
  C5_meth_CS UniProtKB/TrEMBL
  Cytosine_MeTrfase1_RFD UniProtKB/TrEMBL
  DMAP1-bd UniProtKB/TrEMBL
  DNMT1-like UniProtKB/TrEMBL
  SAM-dependent_MTases UniProtKB/TrEMBL
  Znf_CXXC UniProtKB/TrEMBL
NCBI Gene Dnmt1 ENTREZGENE
Pfam BAH UniProtKB/TrEMBL
  DMAP_binding UniProtKB/TrEMBL
  DNA_methylase UniProtKB/TrEMBL
  DNMT1-RFD UniProtKB/TrEMBL
  zf-CXXC UniProtKB/TrEMBL
PIRSF DNMT1 UniProtKB/TrEMBL
PRINTS C5METTRFRASE UniProtKB/TrEMBL
PROSITE BAH UniProtKB/TrEMBL
  C5_MTASE_1 UniProtKB/TrEMBL
  C5_MTASE_2 UniProtKB/TrEMBL
  DMAP1_BIND UniProtKB/TrEMBL
  SAM_MT_C5 UniProtKB/TrEMBL
  ZF_CXXC UniProtKB/TrEMBL
SMART BAH UniProtKB/TrEMBL
  DMAP_binding UniProtKB/TrEMBL
Superfamily-SCOP SSF53335 UniProtKB/TrEMBL
UniProt A0A8C2VD84_CHILA UniProtKB/TrEMBL
  A0A8C2VIL5_CHILA UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2016-08-09 Dnmt1  DNA methyltransferase 1    DNA (cytosine-5-)-methyltransferase 1  Symbol and/or name change 5135510 APPROVED