Ramp2 (receptor activity modifying protein 2)

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Gene: Ramp2 (receptor activity modifying protein 2) Chinchilla lanigera

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Symbol:

Ramp2

Name:

receptor activity modifying protein 2

RGD ID:

8712997

Description:

ENCODES a protein that exhibits adrenomedullin binding (ortholog); adrenomedullin receptor activity (ortholog); amylin receptor activity (ortholog); INVOLVED IN adenylate cyclase-activating G protein-coupled receptor signaling pathway (ortholog); adherens junction assembly (ortholog); adrenomedullin receptor signaling pathway (ortholog); ASSOCIATED WITH adenocarcinoma (ortholog); adult respiratory distress syndrome (ortholog); Cardiomegaly (ortholog); FOUND IN adrenomedullin receptor complex (ortholog); amylin receptor complex 2 (ortholog); cell surface (ortholog)

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

receptor (G protein-coupled) activity modifying protein 2; receptor activity-modifying protein 2

RGD Orthologs

Alliance Genes

More Info

more info ...

Latest Assembly:

ChiLan1.0 - Chinchilla ChiLan1.0 Assembly

NCBI Annotation Information:

Annotation category: partial on reference assembly

Position:

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955451	16,584,742 - 16,586,093 (+)	NCBI	ChiLan1.0	ChiLan1.0

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

adenocarcinoma (ISO)

adult respiratory distress syndrome (ISO)

Cardiomegaly (ISO)

colorectal cancer (ISO)

congestive heart failure (ISO)

Experimental Diabetes Mellitus (ISO)

Experimental Liver Cirrhosis (ISO)

genetic disease (ISO)

hypertension (ISO)

kidney disease (ISO)

Lung Neoplasms (ISO)

Lymphatic Metastasis (ISO)

Myocardial Ischemia (ISO)

Neoplasm Metastasis (ISO)

pulmonary hypertension (ISO)

spleen cancer (ISO)

Starvation (ISO)

Weight Gain (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

adenylate cyclase-activating G protein-coupled receptor signaling pathway (ISO)

adherens junction assembly (ISO)

adrenomedullin receptor signaling pathway (ISO)

amylin receptor signaling pathway (ISO)

angiogenesis (ISO)

basement membrane assembly (ISO)

bicellular tight junction assembly (ISO)

calcium ion transport (ISO)

cellular response to hormone stimulus (ISO)

cellular response to vascular endothelial growth factor stimulus (ISO)

female pregnancy (ISO)

G protein-coupled receptor signaling pathway (ISO)

heart development (ISO)

negative regulation of endothelial cell apoptotic process (ISO)

negative regulation of vascular permeability (ISO)

positive regulation of angiogenesis (ISO)

positive regulation of gene expression (ISO)

positive regulation of protein binding (ISO)

positive regulation of vasculogenesis (ISO)

protein localization to plasma membrane (ISO)

protein transport (ISO)

receptor internalization (ISO)

regulation of blood pressure (ISO)

response to estradiol (ISO)

response to hypoxia (ISO)

response to progesterone (ISO)

sprouting angiogenesis (ISO)

vascular associated smooth muscle cell development (ISO)

vasculogenesis (ISO)

Cellular Component

adrenomedullin receptor complex (ISO)

amylin receptor complex 2 (ISO)

cell surface (ISO)

cytoplasm (ISO)

plasma membrane (ISO)

receptor complex (ISO)

Molecular Function

adrenomedullin binding (ISO)

adrenomedullin receptor activity (ISO)

amylin receptor activity (ISO)

coreceptor activity (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Transitive Annotation Pipeline	Automated assignment of GO, PW and RDO ISO annotations across species

Genomics

Comparative Map Data

Ramp2
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0	NW_004955451	16,584,742 - 16,586,093 (+)	NCBI	ChiLan1.0	ChiLan1.0

RAMP2
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	17	42,761,227 - 42,763,041 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	17	42,758,447 - 42,763,041 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	17	40,913,245 - 40,915,059 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	17	38,166,738 - 38,168,585 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	17	38,166,737 - 38,168,580	NCBI
Celera	17	37,569,491 - 37,571,338 (+)	NCBI		Celera
Cytogenetic Map	17	q21.2	NCBI
HuRef	17	36,678,311 - 36,680,158 (+)	NCBI		HuRef
CHM1_1	17	41,148,776 - 41,150,623 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	17	43,618,368 - 43,620,182 (+)	NCBI		T2T-CHM13v2.0

Ramp2
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	11	101,137,160 - 101,139,076 (+)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	11	101,136,854 - 101,150,372 (+)	Ensembl		GRCm39 Ensembl
GRCm38	11	101,246,334 - 101,248,250 (+)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	11	101,246,028 - 101,259,546 (+)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	11	101,107,648 - 101,109,564 (+)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	11	101,062,424 - 101,064,340 (+)	NCBI		MGSCv36	mm8
Celera	11	112,542,561 - 112,544,477 (+)	NCBI		Celera
Cytogenetic Map	11	D	NCBI
cM Map	11	64.47	NCBI

Ramp2
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	10	86,187,366 - 86,190,692 (+)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	10	86,188,812 - 86,231,829 (+)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	10	91,226,790 - 91,228,598 (+)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	10	90,701,301 - 90,703,109 (+)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	10	86,094,462 - 86,096,270 (+)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	10	89,166,170 - 89,168,962 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	10	89,166,890 - 89,168,965 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	10	88,965,679 - 88,967,458 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	10	90,275,463 - 90,277,242	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	10	90,289,832 - 90,291,611	NCBI
Cytogenetic Map	10	q31	NCBI

RAMP2
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1	17	24,112,840 - 24,115,133 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	17	14,554,888 - 14,557,175 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	17	14,779,666 - 14,781,481 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	17	14,779,666 - 14,781,481 (-)	Ensembl	panpan1.1		panPan2

RAMP2
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	9	20,250,711 - 20,252,485 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
Dog10K_Boxer_Tasha	9	19,712,023 - 19,713,795 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	9	20,969,093 - 20,970,865 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	9	20,969,095 - 20,971,385 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	9	19,753,999 - 19,755,771 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	9	20,020,208 - 20,021,980 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	9	20,122,921 - 20,124,693 (-)	NCBI		UU_Cfam_GSD_1.0

Ramp2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024405602	19,593,351 - 19,595,280 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936490	17,479,650 - 17,482,716 (+)	Ensembl	SpeTri2.0
SpeTri2.0	NW_004936490	17,479,899 - 17,481,788 (+)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

RAMP2
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	12	20,092,196 - 20,094,469 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	12	20,092,204 - 20,094,426 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	12	20,346,948 - 20,349,170 (-)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

RAMP2
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	16	63,526,915 - 63,529,697 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	16	63,526,305 - 63,528,767 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666077	34,320,238 - 34,322,154 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Ramp2
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla 1.0	NW_004624795	1,435,121 - 1,436,421 (-)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Expression

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_005394475	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AGCD01043695	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBCB01022684	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	GBDJ01020216	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

RefSeq Acc Id:

XM_005394475 ⟹ XP_005394532

Type:

CODING

Position:

Chinchilla Assembly	Chr	Position (strand)	Source
ChiLan1.0	NW_004955451	16,584,742 - 16,586,093 (+)	NCBI

Sequence:

show sequence

GCCCTGGGTTCGGGGCTGTGCGCCAGCGCCGCGAACACACACGCGGTGCACCCCGCACCGCAGG
GCTCGGGGCCGCACCCTGGCTTCCCGCTGCAGCCGCGTCCTCGGGGGACCGTGTCCTCTCGCCT
GGGTCTGGACCCCGGGACGGTGTCTGCACTCGGCTGTCCCCTCCGCCGGGCTCCGTGGGGCCGC
TGGCCTCTCTCCCGGGTGTGGCCGACGCCCGTGGGTGTCCCCGGGAAAGGCCCGCTCCCGCTCC
GCCCTGCCTGGCCCGGCTCGCTCGGCGCCGCAGGCCCGGCCCCCGCCCCCCACGTGGCCGCCGC
CGCCGGGCCGGCGAGGAAGCGCGGCTTCCTGCGGCGGACAGAGAGGGGCGCCCGCTGCTCGCCA
TGGCCGCGCACCTCCGCCTGCTGCTGGCTCTGCTCGCGCTGGGAACTGCCCTGCGCCCCCAGGA
GACCCTGGCTCAGCCTCTTCCCACCACCGAGACCCCCGAGTCAGAAGGCAGGATGGTGGACAGC
TATGAGGCCAGCGCCCAGCTTTGCTGGGCCGAATATAAGGGGAATATGGACTTTCTGGAGAAGG
ACTGGTGCAACTGGACCGTGATCAGCAGGCCCTACAGTGCCCTGCGAGACTGCCTGGAGGTGGA
GGCGGAAGTCTTCAGCCTGGGCTTCCCCAACCCCCTGGCCGAGAGGATCATCTTCGAGACCCAC
CAGCTGCACTTCGCCAACTGCTCCCTGGAGCAGCCCACCTTCTGCGACCCCCCGGAGGACGTGC
TCCTGGCCATGATCATAGCCCCCATCTGCCTCATCCCATTTTTCGTCACCCTCGTGGTATGGAG
AAGCAAGGGCACTGAGGTGCAGGCCTAGGGTGGGCGGTGCTGCCAGCGAGATCCCGAGCCTCTC
CCCGCGCCCCCTCTGTGGGGTGCCCCCTCTCACTGCCCCTTCCGAGCCTGGCGCTGGGGTCCTG
GAGCCAGTTTTGTAACCTTCAAAATAAAACTTTTTTTTTTTTGTACGTCA

hide sequence

Protein Sequences


Protein RefSeqs	XP_005394532	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	XP_005394532 ⟸ XM_005394475
- UniProtKB:	A0A8C2VXV5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MAAHLRLLLALLALGTALRPQETLAQPLPTTETPESEGRMVDSYEASAQLCWAEYKGNMDFLEK DWCNWTVISRPYSALRDCLEVEAEVFSLGFPNPLAERIIFETHQLHFANCSLEQPTFCDPPEDV LLAMIIAPICLIPFFVTLVVWRSKGTEVQA hide sequence

Additional Information

External Database Links

Database	Acc Id	Source(s)
Ensembl Genes	ENSCLAG00000015276	UniProtKB/TrEMBL
Ensembl Protein	ENSCLAP00000022274.1	UniProtKB/TrEMBL
Ensembl Transcript	ENSCLAT00000022479.1	UniProtKB/TrEMBL
Gene3D-CATH	Receptor activity modifying family	UniProtKB/TrEMBL
InterPro	RAMP	UniProtKB/TrEMBL
	RAMP_sf	UniProtKB/TrEMBL
NCBI Gene	Ramp2	ENTREZGENE
PANTHER	RECEPTOR ACTIVITY MODIFYING PROTEIN RAMP	UniProtKB/TrEMBL
	RECEPTOR ACTIVITY-MODIFYING PROTEIN 2	UniProtKB/TrEMBL
Pfam	RAMP	UniProtKB/TrEMBL
UniProt	A0A8C2VXV5	ENTREZGENE, UniProtKB/TrEMBL

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2016-08-03	Ramp2	receptor activity modifying protein 2		receptor (G protein-coupled) activity modifying protein 2	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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