Tollip (toll interacting protein) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Gene: Tollip (toll interacting protein) Chinchilla lanigera
Analyze
Symbol: Tollip
Name: toll interacting protein
RGD ID: 8711048
Description: ENCODES a protein that exhibits interleukin-1, type I receptor binding (ortholog); kinase binding (ortholog); molecular adaptor activity (ortholog); INVOLVED IN epithelial cell differentiation (ortholog); interleukin-1-mediated signaling pathway (ortholog); positive regulation of protein sumoylation (ortholog); PARTICIPATES IN interleukin-1 signaling pathway; ASSOCIATED WITH chronic obstructive pulmonary disease (ortholog); delta beta-thalassemia (ortholog); developmental and epileptic encephalopathy (ortholog); FOUND IN nuclear body (ortholog); perinuclear region of cytoplasm (ortholog); protein-containing complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547610,987,223 - 11,010,808 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547610,987,223 - 11,009,134 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Tollip
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495547610,987,223 - 11,010,808 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495547610,987,223 - 11,009,134 (+)NCBIChiLan1.0ChiLan1.0
TOLLIP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38111,274,371 - 1,309,632 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl111,274,371 - 1,309,654 (-)EnsemblGRCh38hg38GRCh38
GRCh37111,295,601 - 1,330,862 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36111,252,177 - 1,287,415 (-)NCBINCBI36Build 36hg18NCBI36
Build 34111,252,176 - 1,287,415NCBI
Celera111,332,006 - 1,366,839 (-)NCBICelera
Cytogenetic Map11p15.5NCBI
HuRef111,087,157 - 1,122,196 (-)NCBIHuRef
CHM1_1111,294,507 - 1,328,900 (-)NCBICHM1_1
T2T-CHM13v2.0111,345,549 - 1,381,261 (-)NCBIT2T-CHM13v2.0
Tollip
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397141,435,317 - 141,456,198 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl7141,428,550 - 141,472,244 (-)EnsemblGRCm39 Ensembl
GRCm387141,881,580 - 141,902,461 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7141,874,813 - 141,918,507 (-)EnsemblGRCm38mm10GRCm38
MGSCv377149,067,490 - 149,088,311 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv367141,690,975 - 141,711,796 (-)NCBIMGSCv36mm8
Celera7141,635,280 - 141,656,101 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map787.34NCBI
Tollip
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81206,391,120 - 206,413,809 (-)NCBIGRCr8
mRatBN7.21196,961,585 - 196,984,252 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1196,950,771 - 196,983,625 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1205,305,293 - 205,326,118 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01212,423,637 - 212,444,459 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01205,097,793 - 205,118,619 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01214,823,993 - 214,844,861 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1214,823,978 - 214,844,858 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01221,737,397 - 221,758,265 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41202,008,799 - 202,029,669 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11202,170,336 - 202,189,385 (-)NCBI
Celera1194,590,002 - 194,610,866 (-)NCBICelera
Cytogenetic Map1q41NCBI
TOLLIP
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v293,691,091 - 3,727,594 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1112,903,417 - 2,940,145 (-)NCBINHGRI_mPanPan1
TOLLIP
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11845,559,385 - 45,578,467 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1845,560,681 - 45,578,449 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1844,170,829 - 44,189,892 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.01846,240,952 - 46,260,016 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl1846,240,952 - 46,308,721 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.11845,688,932 - 45,707,995 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01845,269,721 - 45,288,788 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01846,007,629 - 46,026,693 (-)NCBIUU_Cfam_GSD_1.0
Tollip
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024404947962,528 - 991,542 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936816216,546 - 245,606 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936816216,542 - 245,545 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TOLLIP
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2851,512 - 864,483 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12852,198 - 864,337 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
TOLLIP
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.111,094,535 - 1,127,342 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl11,094,582 - 1,125,045 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366603898,226,602 - 98,258,983 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Tollip
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_00462476621,365,680 - 21,388,471 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_00462476621,365,659 - 21,388,366 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSCLAT00000002040   ⟹   ENSCLAP00000001995
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495547610,987,223 - 11,010,808 (+)Ensembl
RefSeq Acc Id: ENSCLAT00000002041   ⟹   ENSCLAP00000001996
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495547610,994,625 - 11,006,658 (+)Ensembl
RefSeq Acc Id: XM_005401793   ⟹   XP_005401850
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495547610,987,223 - 11,009,134 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005401850 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSCLAP00000001995
  ENSCLAP00000001995.1
  ENSCLAP00000001996.1
Reference Protein Sequences
RefSeq Acc Id: XP_005401850   ⟸   XM_005401793
- UniProtKB: A0A8C2UQS4 (UniProtKB/TrEMBL),   A0A8C2UMN2 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCLAP00000001996   ⟸   ENSCLAT00000002041
RefSeq Acc Id: ENSCLAP00000001995   ⟸   ENSCLAT00000002040
Protein Domains
C2   CUE


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000001459 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000002040 ENTREZGENE
  ENSCLAT00000002040.1 UniProtKB/TrEMBL
  ENSCLAT00000002041.1 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.150 UniProtKB/TrEMBL
  DNA helicase RuvA subunit, C-terminal domain UniProtKB/TrEMBL
InterPro C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  CUE UniProtKB/TrEMBL
  TOLIP_CUE UniProtKB/TrEMBL
  Tollip_C2 UniProtKB/TrEMBL
  UBA-like_sf UniProtKB/TrEMBL
NCBI Gene Tollip ENTREZGENE
PANTHER TOLL-INTERACTING PROTEIN UniProtKB/TrEMBL
  TOLL-INTERACTING PROTEIN UniProtKB/TrEMBL
Pfam CUE UniProtKB/TrEMBL
  PF00168 UniProtKB/TrEMBL
PROSITE CUE UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
SMART CUE UniProtKB/TrEMBL
  SM00239 UniProtKB/TrEMBL
Superfamily-SCOP SSF46934 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
UniProt A0A8C2UMN2 ENTREZGENE, UniProtKB/TrEMBL
  A0A8C2UQS4 ENTREZGENE, UniProtKB/TrEMBL