Pkn1 (protein kinase N1) - Rat Genome Database

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Gene: Pkn1 (protein kinase N1) Chinchilla lanigera
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Symbol: Pkn1
Name: protein kinase N1
RGD ID: 8706603
Description: ENCODES a protein that exhibits chromatin binding (ortholog); diacylglycerol-dependent serine/threonine kinase activity (ortholog); histone binding (ortholog); INVOLVED IN B cell apoptotic process (ortholog); B cell homeostasis (ortholog); epithelial cell migration (ortholog); ASSOCIATED WITH Neointima (ortholog); FOUND IN cleavage furrow (ortholog); cytoplasm (ortholog); cytoplasmic vesicle (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Previously known as: serine/threonine-protein kinase N1
RGD Orthologs
Human
Mouse
Rat
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: ChiLan1.0 - Chinchilla ChiLan1.0 Assembly
Position:
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541533,043,918 - 33,063,567 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541533,040,868 - 33,062,753 (+)NCBIChiLan1.0ChiLan1.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
Neointima  (ISO)

References

References - curated
# Reference Title Reference Citation
1. Transitive Annotation Pipeline Automated assignment of GO, PW and RDO ISO annotations across species
Additional References at PubMed
PMID:22301074   PMID:30032202  


Genomics

Comparative Map Data
Pkn1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541533,043,918 - 33,063,567 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541533,040,868 - 33,062,753 (+)NCBIChiLan1.0ChiLan1.0
PKN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381914,433,306 - 14,471,859 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1914,433,053 - 14,471,867 (+)EnsemblGRCh38hg38GRCh38
GRCh371914,544,118 - 14,582,671 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361914,405,166 - 14,443,679 (+)NCBINCBI36Build 36hg18NCBI36
Build 341914,405,165 - 14,443,678NCBI
Celera1914,438,283 - 14,476,800 (+)NCBICelera
Cytogenetic Map19p13.12NCBI
HuRef1914,121,160 - 14,152,794 (+)NCBIHuRef
CHM1_11914,544,156 - 14,582,658 (+)NCBICHM1_1
T2T-CHM13v2.01914,559,936 - 14,598,492 (+)NCBIT2T-CHM13v2.0
Pkn1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,393,162 - 84,425,819 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl884,393,165 - 84,425,808 (-)EnsemblGRCm39 Ensembl
GRCm38883,666,533 - 83,699,181 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl883,666,536 - 83,699,179 (-)EnsemblGRCm38mm10GRCm38
MGSCv37886,193,995 - 86,223,025 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36886,560,201 - 86,589,231 (-)NCBIMGSCv36mm8
Celera887,960,887 - 87,989,891 (-)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.22NCBI
Pkn1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81941,346,855 - 41,374,832 (+)NCBIGRCr8
mRatBN7.21924,442,130 - 24,470,107 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1924,442,122 - 24,470,107 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1931,263,238 - 31,291,231 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01931,917,654 - 31,945,652 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01934,140,489 - 34,168,479 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01924,803,524 - 24,832,305 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1924,803,524 - 24,831,500 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01935,782,679 - 35,810,655 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41926,132,497 - 26,160,471 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11926,137,378 - 26,165,287 (+)NCBI
Celera1923,985,369 - 24,013,043 (+)NCBICelera
Cytogenetic Map19q11NCBI
PKN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22019,362,860 - 19,401,637 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11918,365,105 - 18,403,896 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01913,996,454 - 14,035,272 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11914,838,478 - 14,879,205 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1914,846,463 - 14,879,205 (+)Ensemblpanpan1.1panPan2
PKN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12048,160,480 - 48,184,346 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2048,160,529 - 48,184,751 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2048,036,227 - 48,059,971 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02048,679,041 - 48,702,797 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2048,679,045 - 48,703,317 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12047,890,581 - 47,914,314 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02048,316,854 - 48,340,898 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02048,559,780 - 48,583,516 (-)NCBIUU_Cfam_GSD_1.0
Pkn1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118207,340,155 - 207,365,294 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049366592,990,937 - 3,014,485 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049366592,990,905 - 3,014,553 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PKN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl264,800,721 - 64,824,957 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1264,800,718 - 64,824,952 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2265,194,139 - 65,211,437 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PKN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1613,088,060 - 13,130,848 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl613,082,132 - 13,130,897 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660746,525,087 - 6,570,118 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Pkn1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046249011,582,790 - 1,605,279 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2


Expression

RNA-SEQ Expression


Sequence


Ensembl Acc Id: ENSCLAT00000023912   ⟹   ENSCLAP00000023686
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0 EnsemblNW_00495541533,043,918 - 33,063,567 (+)Ensembl
RefSeq Acc Id: XM_005381094   ⟹   XP_005381151
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541533,041,080 - 33,062,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005381095   ⟹   XP_005381152
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541533,041,080 - 33,062,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005381096   ⟹   XP_005381153
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541533,043,850 - 33,062,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005381097   ⟹   XP_005381154
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541533,043,850 - 33,062,753 (+)NCBI
Sequence:
RefSeq Acc Id: XM_005381098   ⟹   XP_005381155
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541533,041,080 - 33,062,689 (+)NCBI
Sequence:
RefSeq Acc Id: XM_013512169   ⟹   XP_013367623
Type: CODING
Position:
Chinchilla AssemblyChrPosition (strand)Source
ChiLan1.0NW_00495541533,040,868 - 33,062,753 (+)NCBI
Sequence:
RefSeq Acc Id: XP_005381155   ⟸   XM_005381098
- Peptide Label: isoform X6
- UniProtKB: A0A8C2W967 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005381151   ⟸   XM_005381094
- Peptide Label: isoform X2
- UniProtKB: A0A8C2W967 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005381152   ⟸   XM_005381095
- Peptide Label: isoform X3
- UniProtKB: A0A8C2W967 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005381154   ⟸   XM_005381097
- Peptide Label: isoform X5
- UniProtKB: A0A8C2W967 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_005381153   ⟸   XM_005381096
- Peptide Label: isoform X4
- UniProtKB: A0A8C2W967 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013367623   ⟸   XM_013512169
- Peptide Label: isoform X1
- UniProtKB: A0A8C2W967 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSCLAP00000023686   ⟸   ENSCLAT00000023912
Protein Domains
AGC-kinase C-terminal   C2   Protein kinase   REM-1


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCLAG00000016252 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCLAT00000023912 ENTREZGENE
  ENSCLAT00000023912.1 UniProtKB/TrEMBL
Gene3D-CATH HR1 repeat UniProtKB/TrEMBL
  Transferase(Phosphotransferase) domain 1 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  C2_dom UniProtKB/TrEMBL
  C2_domain_sf UniProtKB/TrEMBL
  C2_PKN UniProtKB/TrEMBL
  HR1_rho-bd UniProtKB/TrEMBL
  HR1_rpt_sf UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  PKN1_HR1_2 UniProtKB/TrEMBL
  PKN_HR1_1 UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Ser_Thr_kinase_AGC UniProtKB/TrEMBL
NCBI Gene Pkn1 ENTREZGENE
PANTHER SERINE/THREONINE-PROTEIN KINASE UniProtKB/TrEMBL
  SERINE_THREONINE-PROTEIN KINASE N1 UniProtKB/TrEMBL
Pfam HR1 UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  PS50004 UniProtKB/TrEMBL
  REM_1 UniProtKB/TrEMBL
SMART Hr1 UniProtKB/TrEMBL
  S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF46585 UniProtKB/TrEMBL
  SSF49562 UniProtKB/TrEMBL
  SSF56112 UniProtKB/TrEMBL
UniProt A0A8C2W967 ENTREZGENE, UniProtKB/TrEMBL