MIR6785 (microRNA 6785) - Rat Genome Database

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Gene: MIR6785 (microRNA 6785) Homo sapiens
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Symbol: MIR6785
Name: microRNA 6785
RGD ID: 8551512
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6785
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1775,498,548 - 75,498,628 (+)EnsemblGRCh38hg38GRCh38
GRCh381775,498,548 - 75,498,628 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371773,494,629 - 73,494,709 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map17q25.1NCBI
HuRef1768,918,186 - 68,918,266 (+)NCBIHuRef
CHM1_11773,559,673 - 73,559,753 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
toluene  (EXP)

References
Additional References at PubMed
PMID:16381832   PMID:22955976   PMID:33015776   PMID:33609542  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:70928
Count of gene targets:21764
Count of transcripts:53688
Interacting mature miRNAs:hsa-miR-6785-3p, hsa-miR-6785-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 733 651 761 79 280 34 942 414 1644 38 652 687 45 336 657
Below cutoff 351 429 164 78 155 50 449 383 677 34 96 88 28 186 296

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000618984
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1775,498,548 - 75,498,628 (+)Ensembl
RefSeq Acc Id: NR_106843
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381775,498,548 - 75,498,628 (+)NCBI
HuRef1768,918,186 - 68,918,266 (+)NCBI
CHM1_11773,559,673 - 73,559,753 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q24.3-25.3(chr17:69916435-83102552)x3 copy number gain See cases [RCV000143342] Chr17:69916435..83102552 [GRCh38]
Chr17:67912576..81048189 [GRCh37]
Chr17:65424171..78653717 [NCBI36]
Chr17:17q24.3-25.3
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q24.3-25.3(chr17:69209079-83086677)x3 copy number gain See cases [RCV000052486] Chr17:69209079..83086677 [GRCh38]
Chr17:67205220..81044553 [GRCh37]
Chr17:64716815..78637842 [NCBI36]
Chr17:17q24.3-25.3
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR6785 COSMIC
Ensembl Genes ENSG00000284595 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000618984 ENTREZGENE
GTEx ENSG00000284595 GTEx
HGNC ID HGNC:50206 ENTREZGENE
Human Proteome Map MIR6785 Human Proteome Map
miRBase MI0022630 ENTREZGENE
NCBI Gene MIR6785 ENTREZGENE
RNAcentral URS0000759E52 RNACentral
  URS000075A0B8 RNACentral
  URS000075D162 RNACentral