MIR6745 (microRNA 6745) - Rat Genome Database

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Gene: MIR6745 (microRNA 6745) Homo sapiens
Analyze
Symbol: MIR6745
Name: microRNA 6745
RGD ID: 8551489
HGNC Page HGNC:50106
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-6745
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381147,179,611 - 47,179,737 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1147,179,611 - 47,179,737 (-)EnsemblGRCh38hg38GRCh38
GRCh371147,201,162 - 47,201,288 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map11p11.2NCBI
HuRef1146,900,138 - 46,900,264 (-)NCBIHuRef
CHM1_11147,199,896 - 47,200,022 (-)NCBICHM1_1
T2T-CHM13v2.01147,336,365 - 47,336,491 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:22955976   PMID:34775375  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11p12-11.2(chr11:41118322-48643003)x1 copy number loss See cases [RCV000135405] Chr11:41118322..48643003 [GRCh38]
Chr11:41139872..48664555 [GRCh37]
Chr11:41096448..48621131 [NCBI36]
Chr11:11p12-11.2		 pathogenic
GRCh38/hg38 11p12-11.12(chr11:39179252-49135735)x1 copy number loss See cases [RCV000137391] Chr11:39179252..49135735 [GRCh38]
Chr11:39200802..49157287 [GRCh37]
Chr11:39157378..49113863 [NCBI36]
Chr11:11p12-11.12		 pathogenic
GRCh38/hg38 11p12-11.12(chr11:42727555-49135735)x3 copy number gain See cases [RCV000139422] Chr11:42727555..49135735 [GRCh38]
Chr11:42749105..49157287 [GRCh37]
Chr11:42705681..49113863 [NCBI36]
Chr11:11p12-11.12		 likely pathogenic
GRCh38/hg38 11p11.2(chr11:46840454-48643003)x1 copy number loss See cases [RCV000051014] Chr11:46840454..48643003 [GRCh38]
Chr11:46862005..48664555 [GRCh37]
Chr11:46818581..48621131 [NCBI36]
Chr11:11p11.2		 pathogenic
GRCh38/hg38 11p12-11.2(chr11:36508280-48643003)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052680]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052680]|See cases [RCV000052680] Chr11:36508280..48643003 [GRCh38]
Chr11:36529830..48664555 [GRCh37]
Chr11:36486406..48621131 [NCBI36]
Chr11:11p12-11.2		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:33488
Count of gene targets:14603
Count of transcripts:30125
Interacting mature miRNAs:hsa-miR-6745
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium
Low 351 755 527 151 40 79 1308 611 554 26 415 504 76 166 988 1
Below cutoff 575 624 355 123 79 73 1133 679 646 43 281 296 53 315 758 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000612694
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1147,179,611 - 47,179,737 (-)Ensembl
RefSeq Acc Id: NR_106803
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381147,179,611 - 47,179,737 (-)NCBI
HuRef1146,900,138 - 46,900,264 (-)NCBI
CHM1_11147,199,896 - 47,200,022 (-)NCBI
T2T-CHM13v2.01147,336,365 - 47,336,491 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR6745 COSMIC
Ensembl Genes ENSG00000275208 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000612694 ENTREZGENE
GTEx ENSG00000275208 GTEx
HGNC ID HGNC:50106 ENTREZGENE
Human Proteome Map MIR6745 Human Proteome Map
miRBase MI0022590 ENTREZGENE
NCBI Gene MIR6745 ENTREZGENE
RNAcentral URS000075AE63 RNACentral
  URS000075C2C8 RNACentral