MIR6835 (microRNA 6835) - Rat Genome Database
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Gene: MIR6835 (microRNA 6835) Homo sapiens
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Symbol: MIR6835
Name: microRNA 6835
RGD ID: 8551470
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6835
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl634,240,673 - 34,240,736 (+)EnsemblGRCh38hg38GRCh38
GRCh38634,240,673 - 34,240,736 (+)NCBIGRCh38GRCh38hg38GRCh38
Cytogenetic Map6p21.31NCBI
HuRef633,931,116 - 33,931,179 (+)NCBIHuRef
CHM1_1634,211,040 - 34,211,103 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:22955976  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:61794
Count of gene targets:21576
Count of transcripts:53649
Interacting mature miRNAs:hsa-miR-6835-3p, hsa-miR-6835-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 60 2 13 6 135 9 118 20 33 16 54 121 4 2
Low 78 30 57 31 264 29 191 44 98 44 83 130 7 9 30 1
Below cutoff 4 7 2 1 7 1 21 8 18 2 4 3 4 14

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000621552
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl634,240,673 - 34,240,736 (+)Ensembl
RefSeq Acc Id: NR_106893
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38634,240,673 - 34,240,736 (+)NCBI
HuRef633,931,116 - 33,931,179 (+)NCBI
CHM1_1634,211,040 - 34,211,103 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR6835 COSMIC
Ensembl Genes ENSG00000276404 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000621552 ENTREZGENE
GTEx ENSG00000276404 GTEx
HGNC ID HGNC:49963 ENTREZGENE
Human Proteome Map MIR6835 Human Proteome Map
miRBase MI0022680 ENTREZGENE
NCBI Gene MIR6835 ENTREZGENE
RNAcentral URS000075A49E RNACentral
  URS000075A5BD RNACentral
  URS000075AE82 RNACentral