MIR6743 (microRNA 6743) - Rat Genome Database

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Gene: MIR6743 (microRNA 6743) Homo sapiens
Analyze
Symbol: MIR6743
Name: microRNA 6743
RGD ID: 8551403
HGNC Page HGNC:50008
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-6743
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3811209,336 - 209,406 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl11209,336 - 209,406 (+)EnsemblGRCh38hg38GRCh38
GRCh3711209,336 - 209,406 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map11p15.5NCBI
HuRef1129,353 - 29,423 (+)NCBIHuRef
CHM1_111208,010 - 208,080 (+)NCBICHM1_1
T2T-CHM13v2.011250,534 - 250,604 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
progesterone  (EXP)

References
Additional References at PubMed
PMID:16381832   PMID:22955976   PMID:30146847  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11p15.5(chr11:196966-244236)x1 copy number loss See cases [RCV000050265] Chr11:196966..244236 [GRCh38]
Chr11:196966..244236 [GRCh37]
Chr11:186966..234236 [NCBI36]
Chr11:11p15.5		 uncertain significance
GRCh38/hg38 11p15.5(chr11:196966-244236)x3 copy number gain See cases [RCV000133626] Chr11:196966..244236 [GRCh38]
Chr11:196966..244236 [GRCh37]
Chr11:186966..234236 [NCBI36]
Chr11:11p15.5		 benign
GRCh38/hg38 11p15.5(chr11:200222-237805)x3 copy number gain See cases [RCV000140063] Chr11:200222..237805 [GRCh38]
Chr11:200222..237805 [GRCh37]
Chr11:190222..227805 [NCBI36]
Chr11:11p15.5		 benign
GRCh38/hg38 11p15.5-15.4(chr11:61793-10727969)x3 copy number gain See cases [RCV000139987] Chr11:61793..10727969 [GRCh38]
Chr11:61793..10749516 [GRCh37]
Chr11:51793..10706092 [NCBI36]
Chr11:11p15.5-15.4		 pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:196855-5321874)x3 copy number gain See cases [RCV000142890] Chr11:196855..5321874 [GRCh38]
Chr11:196855..5343104 [GRCh37]
Chr11:186855..5299680 [NCBI36]
Chr11:11p15.5-15.4		 pathogenic
GRCh38/hg38 11p15.5(chr11:196855-2116185)x3 copy number gain See cases [RCV000142923] Chr11:196855..2116185 [GRCh38]
Chr11:196855..2137415 [GRCh37]
Chr11:186855..2093991 [NCBI36]
Chr11:11p15.5		 pathogenic
GRCh38/hg38 11p15.5(chr11:196966-251588)x3 copy number gain See cases [RCV000051693] Chr11:196966..251588 [GRCh38]
Chr11:196966..251588 [GRCh37]
Chr11:186966..241588 [NCBI36]
Chr11:11p15.5		 uncertain significance
GRCh38/hg38 11p15.5-15.4(chr11:196966-4435344)x3 copy number gain See cases [RCV000050927] Chr11:196966..4435344 [GRCh38]
Chr11:196966..4456574 [GRCh37]
Chr11:186966..4413150 [NCBI36]
Chr11:11p15.5-15.4		 pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:196966-3377077)x3 copy number gain See cases [RCV000050947] Chr11:196966..3377077 [GRCh38]
Chr11:196966..3398307 [GRCh37]
Chr11:186966..3354883 [NCBI36]
Chr11:11p15.5-15.4		 pathogenic
GRCh38/hg38 11p15.5-13(chr11:202758-31726224)x3 copy number gain See cases [RCV000053613] Chr11:202758..31726224 [GRCh38]
Chr11:202758..31747772 [GRCh37]
Chr11:192758..31704348 [NCBI36]
Chr11:11p15.5-13		 pathogenic
GRCh38/hg38 11p15.5-15.4(chr11:196966-3624139)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053592]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053592]|See cases [RCV000053592] Chr11:196966..3624139 [GRCh38]
Chr11:196966..3645369 [GRCh37]
Chr11:186966..3601945 [NCBI36]
Chr11:11p15.5-15.4		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:81384
Count of gene targets:23404
Count of transcripts:62859
Interacting mature miRNAs:hsa-miR-6743-3p, hsa-miR-6743-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000611346
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl11209,336 - 209,406 (+)Ensembl
RefSeq Acc Id: NR_106801
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3811209,336 - 209,406 (+)NCBI
HuRef1129,353 - 29,423 (+)NCBI
CHM1_111208,010 - 208,080 (+)NCBI
T2T-CHM13v2.011250,534 - 250,604 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR6743 COSMIC
Ensembl Genes ENSG00000283920 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000611346 ENTREZGENE
GTEx ENSG00000283920 GTEx
HGNC ID HGNC:50008 ENTREZGENE
Human Proteome Map MIR6743 Human Proteome Map
miRBase MI0022588 ENTREZGENE
NCBI Gene MIR6743 ENTREZGENE
RNAcentral URS0000759F68 RNACentral
  URS000075A77C RNACentral
  URS000075E7A2 RNACentral