MIR6132 (microRNA 6132) - Rat Genome Database
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Gene: MIR6132 (microRNA 6132) Homo sapiens
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Symbol: MIR6132
Name: microRNA 6132
RGD ID: 8551327
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6132
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl7117,020,211 - 117,020,319 (+)EnsemblGRCh38hg38GRCh38
GRCh387117,020,211 - 117,020,319 (+)NCBIGRCh38GRCh38hg38GRCh38
Cytogenetic Map7q31.2NCBI
HuRef7111,025,483 - 111,025,591 (+)NCBIHuRef
CHM1_17116,593,929 - 116,594,037 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:22454130  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:51166
Count of gene targets:17812
Count of transcripts:43694
Interacting mature miRNAs:hsa-miR-6132
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENST00000622083
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl7117,020,211 - 117,020,319 (+)Ensembl
RefSeq Acc Id: NR_106748
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh387117,020,211 - 117,020,319 (+)NCBI
HuRef7111,025,483 - 111,025,591 (+)NCBI
CHM1_17116,593,929 - 116,594,037 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 7q31.1-31.33(chr7:114142477-125840381)x1 copy number loss See cases [RCV000135311] Chr7:114142477..125840381 [GRCh38]
Chr7:113782532..125480435 [GRCh37]
Chr7:113569768..125267671 [NCBI36]
Chr7:7q31.1-31.33
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:54185-159282390)x1 copy number loss See cases [RCV000135401] Chr7:54185..159282390 [GRCh38]
Chr7:54185..159075079 [GRCh37]
Chr7:149268..158767840 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q21.3-36.3(chr7:97419852-158923762)x3 copy number gain See cases [RCV000136717] Chr7:97419852..158923762 [GRCh38]
Chr7:97049164..158716453 [GRCh37]
Chr7:96887100..158409214 [NCBI36]
Chr7:7q21.3-36.3
pathogenic
GRCh38/hg38 7q22.1-31.31(chr7:102196924-121278641)x1 copy number loss See cases [RCV000137522] Chr7:102196924..121278641 [GRCh38]
Chr7:101912320..120918695 [GRCh37]
Chr7:101626924..120705931 [NCBI36]
Chr7:7q22.1-31.31
pathogenic
GRCh38/hg38 7q31.2-36.3(chr7:115459015-159325817)x3 copy number gain See cases [RCV000141413] Chr7:115459015..159325817 [GRCh38]
Chr7:115099069..159118507 [GRCh37]
Chr7:114886305..158811268 [NCBI36]
Chr7:7q31.2-36.3
pathogenic
GRCh38/hg38 7q31.1-31.31(chr7:114898882-117790123)x1 copy number loss See cases [RCV000142459] Chr7:114898882..117790123 [GRCh38]
Chr7:114538937..117430177 [GRCh37]
Chr7:114326173..117217413 [NCBI36]
Chr7:7q31.1-31.31
pathogenic
GRCh38/hg38 7q31.1-31.2(chr7:114389395-117253741)x1 copy number loss See cases [RCV000143413] Chr7:114389395..117253741 [GRCh38]
Chr7:114029450..116893795 [GRCh37]
Chr7:113816686..116681031 [NCBI36]
Chr7:7q31.1-31.2
pathogenic
GRCh38/hg38 7p22.3-q36.3(chr7:53985-159282531)x1 copy number loss See cases [RCV000052250] Chr7:53985..159282531 [GRCh38]
Chr7:53985..159075220 [GRCh37]
Chr7:149068..158767981 [NCBI36]
Chr7:7p22.3-q36.3
pathogenic
GRCh38/hg38 7q31.1-31.31(chr7:110524677-118306203)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054159]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000054159]|See cases [RCV000054159] Chr7:110524677..118306203 [GRCh38]
Chr7:110164734..117946257 [GRCh37]
Chr7:109951970..117733493 [NCBI36]
Chr7:7q31.1-31.31
pathogenic
GRCh38/hg38 7q31.1-31.33(chr7:113799835-124899218)x1 copy number loss See cases [RCV000054160] Chr7:113799835..124899218 [GRCh38]
Chr7:113439890..124539272 [GRCh37]
Chr7:113227126..124326508 [NCBI36]
Chr7:7q31.1-31.33
pathogenic
NC_000007.13:g.(?_116339129)_(117144427_?)dup duplication Renal cell carcinoma, papillary, 1 [RCV000707756] Chr7:116699075..117504373 [GRCh38]
Chr7:116339129..117144427 [GRCh37]
Chr7:7q31.2
uncertain significance

Additional Information

Database Acc Id Source(s)
COSMIC MIR6132 COSMIC
Ensembl Genes ENSG00000283923 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000622083 ENTREZGENE
GTEx ENSG00000283923 GTEx
HGNC ID HGNC:50272 ENTREZGENE
Human Proteome Map MIR6132 Human Proteome Map
miRBase MI0021277 ENTREZGENE
NCBI Gene MIR6132 ENTREZGENE
RNAcentral URS000075A7DE RNACentral
  URS000075C834 RNACentral