MIR7852 (microRNA 7852) - Rat Genome Database

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Gene: MIR7852 (microRNA 7852) Homo sapiens
Analyze
Symbol: MIR7852
Name: microRNA 7852
RGD ID: 8551262
HGNC Page HGNC:50201
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-7852
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381107,897,223 - 107,897,304 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1107,897,223 - 107,897,304 (+)EnsemblGRCh38hg38GRCh38
GRCh371108,439,845 - 108,439,926 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1p13.3NCBI
HuRef1106,385,615 - 106,385,696 (+)NCBIHuRef
CHM1_11108,554,658 - 108,554,739 (+)NCBICHM1_1
T2T-CHM13v2.01107,934,690 - 107,934,771 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Phenotype Annotations     Click to see Annotation Detail View

Human Phenotype
Autism  (IAGP)
References
Additional References at PubMed
PMID:16381832   PMID:23226537  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p13.3(chr1:107456821-108010045)x3 copy number gain See cases [RCV000133828] Chr1:107456821..108010045 [GRCh38]
Chr1:107999443..108552667 [GRCh37]
Chr1:107800966..108354190 [NCBI36]
Chr1:1p13.3		 uncertain significance
GRCh38/hg38 1p13.3(chr1:107395369-108383738)x3 copy number gain See cases [RCV000134068] Chr1:107395369..108383738 [GRCh38]
Chr1:107937991..108926360 [GRCh37]
Chr1:107739514..108727883 [NCBI36]
Chr1:1p13.3		 uncertain significance
GRCh38/hg38 1p21.3-13.3(chr1:97272349-108893138)x1 copy number loss See cases [RCV000135333] Chr1:97272349..108893138 [GRCh38]
Chr1:97737905..109435760 [GRCh37]
Chr1:97510493..109237283 [NCBI36]
Chr1:1p21.3-13.3		 pathogenic
GRCh38/hg38 1p21.1-12(chr1:104325484-119977655)x3 copy number gain See cases [RCV000142953] Chr1:104325484..119977655 [GRCh38]
Chr1:104868106..120471049 [GRCh37]
Chr1:104669629..120321801 [NCBI36]
Chr1:1p21.1-12		 pathogenic
GRCh38/hg38 1p21.1-13.2(chr1:105468292-112190626)x1 copy number loss See cases [RCV000142760] Chr1:105468292..112190626 [GRCh38]
Chr1:106010914..112733248 [GRCh37]
Chr1:105812437..112534771 [NCBI36]
Chr1:1p21.1-13.2		 pathogenic
GRCh38/hg38 1p21.3-13.3(chr1:97410602-110670510)x1 copy number loss See cases [RCV000053877] Chr1:97410602..110670510 [GRCh38]
Chr1:97876158..111213132 [GRCh37]
Chr1:97648746..111014655 [NCBI36]
Chr1:1p21.3-13.3		 pathogenic
GRCh38/hg38 1p21.3-13.3(chr1:98557000-107949047)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053878]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053878]|See cases [RCV000053878] Chr1:98557000..107949047 [GRCh38]
Chr1:99022556..108491669 [GRCh37]
Chr1:98795144..108293192 [NCBI36]
Chr1:1p21.3-13.3		 pathogenic
GRCh38/hg38 1p21.2-13.2(chr1:101618097-111703028)x1 copy number loss See cases [RCV000053879] Chr1:101618097..111703028 [GRCh38]
Chr1:102083653..112245650 [GRCh37]
Chr1:101856241..112047173 [NCBI36]
Chr1:1p21.2-13.2		 pathogenic
GRCh38/hg38 1p21.1-13.3(chr1:106074587-110144290)x1 copy number loss See cases [RCV000053881] Chr1:106074587..110144290 [GRCh38]
Chr1:106617209..110686912 [GRCh37]
Chr1:106418732..110488435 [NCBI36]
Chr1:1p21.1-13.3		 pathogenic
NC_000001.11:g.(?_103175204)_(111410059_?)del deletion Autism [RCV000754122] Chr1:103175204..111410059 [GRCh38]
Chr1:1p21.1-13.2		 likely pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:7258
Count of gene targets:3367
Count of transcripts:5901
Interacting mature miRNAs:hsa-miR-7852-3p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system nervous system respiratory system
High
Medium
Low 2 1 4 1
Below cutoff 3 2 2 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000617442
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1107,897,223 - 107,897,304 (+)Ensembl
RefSeq Acc Id: NR_107006
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381107,897,223 - 107,897,304 (+)NCBI
HuRef1106,385,615 - 106,385,696 (+)NCBI
CHM1_11108,554,658 - 108,554,739 (+)NCBI
T2T-CHM13v2.01107,934,690 - 107,934,771 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR7852 COSMIC
Ensembl Genes ENSG00000275455 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000617442 ENTREZGENE
GTEx ENSG00000275455 GTEx
HGNC ID HGNC:50201 ENTREZGENE
Human Proteome Map MIR7852 Human Proteome Map
miRBase MI0025522 ENTREZGENE
NCBI Gene MIR7852 ENTREZGENE
RNAcentral URS000075B643 RNACentral
  URS000075B70F RNACentral