MIR6514 (microRNA 6514) - Rat Genome Database

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Gene: MIR6514 (microRNA 6514) Homo sapiens
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Symbol: MIR6514
Name: microRNA 6514
RGD ID: 8551146
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6514; mir-6514
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1162,792,702 - 62,792,771 (-)EnsemblGRCh38hg38GRCh38
GRCh381162,792,702 - 62,792,771 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371162,560,174 - 62,560,243 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map11q12.3NCBI
HuRef1158,889,200 - 58,889,269 (-)NCBIHuRef
CHM1_11162,443,256 - 62,443,325 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:21037258   PMID:21807764  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:43069
Count of gene targets:15402
Count of transcripts:31788
Interacting mature miRNAs:hsa-miR-6514-3p, hsa-miR-6514-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 3 1 1 1
Low 87 69 54 27 253 30 146 47 94 32 98 147 3 20 30 2
Below cutoff 32 30 14 2 50 2 41 32 37 11 15 28 1 14 16 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000622549
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1162,792,702 - 62,792,771 (-)Ensembl
RefSeq Acc Id: NR_106769
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,792,702 - 62,792,771 (-)NCBI
HuRef1158,889,200 - 58,889,269 (-)NCBI
CHM1_11162,443,256 - 62,443,325 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q12.3(chr11:62562836-62840570)x3 copy number gain See cases [RCV000134807] Chr11:62562836..62840570 [GRCh38]
Chr11:62330308..62608042 [GRCh37]
Chr11:62086884..62364618 [NCBI36]
Chr11:11q12.3
uncertain significance
GRCh38/hg38 11q12.3(chr11:62249520-62946093)x3 copy number gain See cases [RCV000138411] Chr11:62249520..62946093 [GRCh38]
Chr11:62016992..62713565 [GRCh37]
Chr11:61773568..62470141 [NCBI36]
Chr11:11q12.3
pathogenic
GRCh38/hg38 11q12.3(chr11:62433886-63096003)x3 copy number gain See cases [RCV000053620] Chr11:62433886..63096003 [GRCh38]
Chr11:62201358..62863475 [GRCh37]
Chr11:61957934..62620051 [NCBI36]
Chr11:11q12.3
pathogenic
GRCh38/hg38 11q12.3(chr11:62452571-62862781)x3 copy number gain See cases [RCV000053621] Chr11:62452571..62862781 [GRCh38]
Chr11:62220043..62630253 [GRCh37]
Chr11:61976619..62386829 [NCBI36]
Chr11:11q12.3
pathogenic
NM_006362.5(NXF1):c.1761-4C>A single nucleotide variant not provided [RCV000924234] Chr11:62792705 [GRCh38]
Chr11:62560177 [GRCh37]
Chr11:11q12.3
likely benign

Additional Information

Database Acc Id Source(s)
COSMIC MIR6514 COSMIC
Ensembl Genes ENSG00000274066 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000622549 ENTREZGENE
GTEx ENSG00000274066 GTEx
HGNC ID HGNC:50147 ENTREZGENE
Human Proteome Map MIR6514 Human Proteome Map
miRBase MI0022226 ENTREZGENE
NCBI Gene MIR6514 ENTREZGENE
RNAcentral URS000075B538 RNACentral
  URS000075BA81 RNACentral
  URS000075C48C RNACentral