MIR5787 (microRNA 5787) - Rat Genome Database

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Gene: MIR5787 (microRNA 5787) Homo sapiens
Analyze
Symbol: MIR5787
Name: microRNA 5787
RGD ID: 8551126
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-5787
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl350,227,436 - 50,227,490 (+)EnsemblGRCh38hg38GRCh38
GRCh38350,227,436 - 50,227,490 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37350,264,868 - 50,264,922 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map3p21.31NCBI
HuRef350,320,556 - 50,320,610 (+)NCBIHuRef
CHM1_1350,217,143 - 50,217,197 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
cyclosporin A  (EXP)
toluene  (EXP)

References
Additional References at PubMed
PMID:16381832   PMID:22062548   PMID:34247256  


Genomics

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
ELF5hsa-miR-5787Mirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22062548

Predicted Targets
Summary Value
Count of predictions:89482
Count of gene targets:24459
Count of transcripts:65059
Interacting mature miRNAs:hsa-miR-5787
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 1 1 1
Low 66 55 44 12 109 10 117 63 96 11 43 108 6 23 62
Below cutoff 10 10 5 4 21 6 11 15 30 6 9 4 1 5

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000611784
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl350,227,436 - 50,227,490 (+)Ensembl
RefSeq Acc Id: NR_106714
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38350,227,436 - 50,227,490 (+)NCBI
HuRef350,320,556 - 50,320,610 (+)NCBI
CHM1_1350,217,143 - 50,217,197 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p21.31-21.2(chr3:45879883-50749922)x4 copy number gain See cases [RCV000133650] Chr3:45879883..50749922 [GRCh38]
Chr3:45921375..50787353 [GRCh37]
Chr3:45896379..50762357 [NCBI36]
Chr3:3p21.31-21.2
pathogenic
GRCh38/hg38 3p21.31-14.3(chr3:49461000-55314500)x1 copy number loss See cases [RCV000051511] Chr3:49461000..55314500 [GRCh38]
Chr3:49498433..55348528 [GRCh37]
Chr3:49473437..55323568 [NCBI36]
Chr3:3p21.31-14.3
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR5787 COSMIC
Ensembl Genes ENSG00000275334 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000611784 ENTREZGENE
GTEx ENSG00000275334 GTEx
HGNC ID HGNC:49930 ENTREZGENE
Human Proteome Map MIR5787 Human Proteome Map
miRBase MI0019797 ENTREZGENE
NCBI Gene MIR5787 ENTREZGENE
RNAcentral URS000075B8AF RNACentral
  URS000075CA3A RNACentral