MIR6753 (microRNA 6753) - Rat Genome Database

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Gene: MIR6753 (microRNA 6753) Homo sapiens
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Symbol: MIR6753
Name: microRNA 6753
RGD ID: 8551098
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6753
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1168,044,794 - 68,044,957 (+)EnsemblGRCh38hg38GRCh38
GRCh381168,044,794 - 68,044,957 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371167,812,261 - 67,812,424 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map11q13.2NCBI
HuRef1164,147,605 - 64,147,768 (+)NCBIHuRef
CHM1_11167,696,018 - 67,696,181 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:22955976  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:52606
Count of gene targets:17206
Count of transcripts:41465
Interacting mature miRNAs:hsa-miR-6753-3p, hsa-miR-6753-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 6 164 5 3 234 3 5 2 8 3 11 105 3
Low 1922 1976 1168 308 1412 171 2186 890 962 122 900 1252 145 1006 1278 4
Below cutoff 303 585 212 87 28 71 1027 685 967 33 169 65 17 155 709

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000617169
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1168,044,794 - 68,044,957 (+)Ensembl
RefSeq Acc Id: NR_106811
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381168,044,794 - 68,044,957 (+)NCBI
HuRef1164,147,605 - 64,147,768 (+)NCBI
CHM1_11167,696,018 - 67,696,181 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q13.2-13.3(chr11:67217264-69448598)x1 copy number loss See cases [RCV000135609] Chr11:67217264..69448598 [GRCh38]
Chr11:66984735..69263366 [GRCh37]
Chr11:66741311..68972547 [NCBI36]
Chr11:11q13.2-13.3
likely pathogenic
GRCh38/hg38 11q13.2-13.4(chr11:68031693-71593495)x1 copy number loss See cases [RCV000142138] Chr11:68031693..71593495 [GRCh38]
Chr11:67799160..71304541 [GRCh37]
Chr11:67555736..70982189 [NCBI36]
Chr11:11q13.2-13.4
likely pathogenic
GRCh38/hg38 11q13.2(chr11:67446153-68679073)x1 copy number loss See cases [RCV000052683] Chr11:67446153..68679073 [GRCh38]
Chr11:67213624..68446541 [GRCh37]
Chr11:66970200..68203117 [NCBI36]
Chr11:11q13.2
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR6753 COSMIC
Ensembl Genes ENSG00000275022 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000617169 ENTREZGENE
GTEx ENSG00000275022 GTEx
HGNC ID HGNC:50255 ENTREZGENE
Human Proteome Map MIR6753 Human Proteome Map
miRBase MI0022598 ENTREZGENE
NCBI Gene MIR6753 ENTREZGENE
RNAcentral URS000075A4C6 RNACentral
  URS000075CB3A RNACentral
  URS000075EF1E RNACentral