MIR6884 (microRNA 6884) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: MIR6884 (microRNA 6884) Homo sapiens
Analyze
Symbol: MIR6884
Name: microRNA 6884
RGD ID: 8551048
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6884
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1740,026,332 - 40,026,409 (-)EnsemblGRCh38hg38GRCh38
GRCh381740,026,332 - 40,026,409 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371738,182,585 - 38,182,662 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map17q21.1NCBI
HuRef1733,976,477 - 33,976,554 (-)NCBIHuRef
CHM1_11738,418,283 - 38,418,360 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:22955976  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:60189
Count of gene targets:19402
Count of transcripts:44318
Interacting mature miRNAs:hsa-miR-6884-3p, hsa-miR-6884-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 381 339 256 34 106 5 1023 259 426 3 245 320 29 226 654
Below cutoff 238 176 133 45 97 19 388 250 246 17 72 67 26 122 264

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_106944 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC102799 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000614287
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1740,026,332 - 40,026,409 (-)Ensembl
RefSeq Acc Id: NR_106944
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381740,026,332 - 40,026,409 (-)NCBI
HuRef1733,976,477 - 33,976,554 (-)NCBI
CHM1_11738,418,283 - 38,418,360 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q23.1-25.1(chr17:36449220-75053130)x3 copy number gain See cases [RCV000137437] Chr17:36449220..75053130 [GRCh38]
Chr17:57595736..73049225 [GRCh37]
Chr17:54950518..70560820 [NCBI36]
Chr17:17q23.1-25.1
pathogenic
GRCh38/hg38 17q21.1(chr17:39876786-40048205)x1 copy number loss See cases [RCV000142465] Chr17:39876786..40048205 [GRCh38]
Chr17:38033039..38204458 [GRCh37]
Chr17:35286565..35457984 [NCBI36]
Chr17:17q21.1
uncertain significance
GRCh38/hg38 17q21.33-24.2(chr17:36449220-68170214)x3 copy number gain See cases [RCV000050957] Chr17:36449220..68170214 [GRCh38]
Chr17:48563237..65936105 [GRCh37]
Chr17:45918236..63677950 [NCBI36]
Chr17:17q21.33-24.2
pathogenic
GRCh38/hg38 17q12-21.31(chr17:39199873-45629579)x3 copy number gain See cases [RCV000052479] Chr17:39199873..45629579 [GRCh38]
Chr17:37356126..43706945 [GRCh37]
Chr17:34609652..41062728 [NCBI36]
Chr17:17q12-21.31
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR6884 COSMIC
Ensembl Genes ENSG00000283721 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000614287 ENTREZGENE
GTEx ENSG00000283721 GTEx
HGNC ID HGNC:50091 ENTREZGENE
Human Proteome Map MIR6884 Human Proteome Map
miRBase MI0022731 ENTREZGENE
NCBI Gene MIR6884 ENTREZGENE
RNAcentral URS0000759FCF RNACentral
  URS000075AC98 RNACentral
  URS000075E1B2 RNACentral