MIR8080 (microRNA 8080) - Rat Genome Database

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Gene: MIR8080 (microRNA 8080) Homo sapiens
Analyze
Symbol: MIR8080
Name: microRNA 8080
RGD ID: 8550928
HGNC Page HGNC:49989
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-8080
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38279,866,495 - 79,866,583 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl279,866,495 - 79,866,583 (-)EnsemblGRCh38hg38GRCh38
GRCh37280,093,621 - 80,093,709 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map2p12NCBI
HuRef279,829,011 - 79,829,099 (-)NCBIHuRef
CHM1_1280,022,923 - 80,023,011 (-)NCBICHM1_1
T2T-CHM13v2.0279,866,790 - 79,866,878 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:23612084  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p12-11.2(chr2:77025216-90282666)x3 copy number gain See cases [RCV000134786] Chr2:77025216..90282666 [GRCh38]
Chr2:77252342..91619262 [GRCh37]
Chr2:77105850..90982989 [NCBI36]
Chr2:2p12-11.2		 pathogenic
GRCh38/hg38 2p12(chr2:79680727-80974466)x3 copy number gain See cases [RCV000135457] Chr2:79680727..80974466 [GRCh38]
Chr2:79907853..81201590 [GRCh37]
Chr2:79761361..81055101 [NCBI36]
Chr2:2p12		 uncertain significance
GRCh38/hg38 2p16.1-11.2(chr2:58279519-83586962)x3 copy number gain See cases [RCV000136053] Chr2:58279519..83586962 [GRCh38]
Chr2:58506654..83814086 [GRCh37]
Chr2:58360158..83667597 [NCBI36]
Chr2:2p16.1-11.2		 pathogenic
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2		 uncertain significance
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2		 benign
GRCh38/hg38 2p12(chr2:79252886-81305516)x1 copy number loss See cases [RCV000143017] Chr2:79252886..81305516 [GRCh38]
Chr2:79480012..81532640 [GRCh37]
Chr2:79333520..81386151 [NCBI36]
Chr2:2p12		 uncertain significance
GRCh38/hg38 2p12(chr2:79119966-80133374)x3 copy number gain See cases [RCV000143643] Chr2:79119966..80133374 [GRCh38]
Chr2:79347092..80360500 [GRCh37]
Chr2:79200600..80214011 [NCBI36]
Chr2:2p12		 uncertain significance
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:15000
Count of gene targets:6217
Count of transcripts:11552
Interacting mature miRNAs:hsa-miR-8080
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage
High
Medium
Low 4 2 4 4 2 18 2 6 3 1 2
Below cutoff 6 1 8 2 2 31 19 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000622224
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl279,866,495 - 79,866,583 (-)Ensembl
RefSeq Acc Id: NR_107047
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38279,866,495 - 79,866,583 (-)NCBI
HuRef279,829,011 - 79,829,099 (-)NCBI
CHM1_1280,022,923 - 80,023,011 (-)NCBI
T2T-CHM13v2.0279,866,790 - 79,866,878 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR8080 COSMIC
Ensembl Genes ENSG00000276917 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000622224 ENTREZGENE
GTEx ENSG00000276917 GTEx
HGNC ID HGNC:49989 ENTREZGENE
Human Proteome Map MIR8080 Human Proteome Map
miRBase MI0025916 ENTREZGENE
NCBI Gene MIR8080 ENTREZGENE
RNAcentral URS000075AAE2 RNACentral
  URS000075DFCA RNACentral