MIR6769B (microRNA 6769b) - Rat Genome Database

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Gene: MIR6769B (microRNA 6769b) Homo sapiens
Analyze
Symbol: MIR6769B
Name: microRNA 6769b
RGD ID: 8550851
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6769b
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1206,474,803 - 206,474,864 (+)EnsemblGRCh38hg38GRCh38
GRCh381206,474,803 - 206,474,864 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371206,648,146 - 206,648,207 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1q32.1NCBI
HuRef1177,346,396 - 177,346,455 (+)NCBIHuRef
CHM1_11207,920,342 - 207,920,403 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
toluene  (EXP)

References
Additional References at PubMed
PMID:16381832   PMID:22955976  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:72014
Count of gene targets:21716
Count of transcripts:55066
Interacting mature miRNAs:hsa-miR-6769b-3p, hsa-miR-6769b-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system appendage
High
Medium
Low 9 11 3 3 22 8 5 5 2 5 3 5
Below cutoff 8 1 2 1 18 1 3 2 6 1 2 3 1 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000622159
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1206,474,803 - 206,474,864 (+)Ensembl
RefSeq Acc Id: NR_106919
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381206,474,803 - 206,474,864 (+)NCBI
HuRef1177,346,396 - 177,346,455 (+)NCBI
CHM1_11207,920,342 - 207,920,403 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q32.1-42.12(chr1:204764914-225408698)x3 copy number gain See cases [RCV000142054] Chr1:204764914..225408698 [GRCh38]
Chr1:204734042..225596400 [GRCh37]
Chr1:203000665..223663023 [NCBI36]
Chr1:1q32.1-42.12
pathogenic
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11
pathogenic
GRCh38/hg38 1q32.1-32.2(chr1:204990129-210220258)x3 copy number gain See cases [RCV000051859] Chr1:204990129..210220258 [GRCh38]
Chr1:204959257..210572305 [GRCh37]
Chr1:203225880..208638928 [NCBI36]
Chr1:1q32.1-32.2
pathogenic
NC_000001.11:g.(?_204033173)_(208209798_?)del deletion Autistic disorder of childhood onset [RCV000754138] Chr1:204033173..208209798 [GRCh38]
Chr1:1q32.1-32.2
likely pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR6769B COSMIC
Ensembl Genes ENSG00000278465 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000622159 ENTREZGENE
GTEx ENSG00000278465 GTEx
HGNC ID HGNC:50016 ENTREZGENE
Human Proteome Map MIR6769B Human Proteome Map
miRBase MI0022706 ENTREZGENE
NCBI Gene MIR6769B ENTREZGENE
RNAcentral URS000075B1DF RNACentral
  URS000075C6AD RNACentral
  URS000075CAD0 RNACentral