MIR6762 (microRNA 6762) - Rat Genome Database
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Gene: MIR6762 (microRNA 6762) Homo sapiens
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Symbol: MIR6762
Name: microRNA 6762
RGD ID: 8550744
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6762
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12113,291,523 - 113,291,608 (+)EnsemblGRCh38hg38GRCh38
GRCh3812113,291,523 - 113,291,608 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712113,729,328 - 113,729,413 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12q24.13NCBI
HuRef12110,741,819 - 110,741,904 (+)NCBIHuRef
CHM1_112113,697,576 - 113,697,661 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:22955976  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:115088
Count of gene targets:28073
Count of transcripts:82164
Interacting mature miRNAs:hsa-miR-6762-3p, hsa-miR-6762-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1
Low 166 377 321 43 149 15 710 95 303 23 200 401 32 142 494
Below cutoff 184 228 163 41 110 17 406 197 261 31 99 123 25 120 226 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_106820 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC010178 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000613340
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12113,291,523 - 113,291,608 (+)Ensembl
RefSeq Acc Id: NR_106820
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812113,291,523 - 113,291,608 (+)NCBI
HuRef12110,741,819 - 110,741,904 (+)NCBI
CHM1_112113,697,576 - 113,697,661 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q24.13-24.21(chr12:113077775-114372366)x1 copy number loss See cases [RCV000143532] Chr12:113077775..114372366 [GRCh38]
Chr12:113515580..114810171 [GRCh37]
Chr12:111999963..113294554 [NCBI36]
Chr12:12q24.13-24.21
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR6762 COSMIC
Ensembl Genes ENSG00000274822 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000613340 ENTREZGENE
GTEx ENSG00000274822 GTEx
HGNC ID HGNC:50168 ENTREZGENE
Human Proteome Map MIR6762 Human Proteome Map
miRBase MI0022607 ENTREZGENE
NCBI Gene MIR6762 ENTREZGENE
RNAcentral URS000075B2A2 RNACentral
  URS000075C247 RNACentral
  URS000075CFC5 RNACentral