MIR6721 (microRNA 6721) - Rat Genome Database

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Gene: MIR6721 (microRNA 6721) Homo sapiens
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Symbol: MIR6721
Name: microRNA 6721
RGD ID: 8550681
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6721; mir-6721
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl632,170,030 - 32,170,116 (-)EnsemblGRCh38hg38GRCh38
GRCh38632,170,030 - 32,170,116 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37632,137,807 - 32,137,893 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map6p21.32NCBI
HuRef631,892,006 - 31,892,092 (-)NCBIHuRef
CHM1_1632,140,291 - 32,140,377 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:21037258   PMID:22313525  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:76698
Count of gene targets:22124
Count of transcripts:58008
Interacting mature miRNAs:hsa-miR-6721-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 1
Low 152 121 155 20 65 12 193 98 260 11 148 160 8 68 147
Below cutoff 111 124 69 19 45 14 122 129 233 8 61 25 5 45 91

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000617181
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl632,170,030 - 32,170,116 (-)Ensembl
RefSeq Acc Id: NR_106779
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38632,170,030 - 32,170,116 (-)NCBI
HuRef631,892,006 - 31,892,092 (-)NCBI
CHM1_1632,140,291 - 32,140,377 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 6p25.3-12.3(chr6:156974-46789291)x3 copy number gain See cases [RCV000143497] Chr6:156974..46789291 [GRCh38]
Chr6:156974..46757028 [GRCh37]
Chr6:101974..46864987 [NCBI36]
Chr6:6p25.3-12.3
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR6721 COSMIC
Ensembl Genes ENSG00000284469 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000617181 ENTREZGENE
GTEx ENSG00000284469 GTEx
HGNC ID HGNC:50049 ENTREZGENE
Human Proteome Map MIR6721 Human Proteome Map
miRBase MI0022556 ENTREZGENE
NCBI Gene MIR6721 ENTREZGENE
RNAcentral URS000075D15B RNACentral
  URS000075E1DC RNACentral