MIR6735 (microRNA 6735) - Rat Genome Database

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Gene: MIR6735 (microRNA 6735) Homo sapiens
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Symbol: MIR6735
Name: microRNA 6735
RGD ID: 8550598
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6735
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl143,448,539 - 43,448,611 (+)EnsemblGRCh38hg38GRCh38
GRCh38143,448,539 - 43,448,611 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37143,914,210 - 43,914,282 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1p34.2NCBI
HuRef142,033,355 - 42,033,427 (+)NCBIHuRef
CHM1_1144,030,578 - 44,030,650 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:22955976  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:97076
Count of gene targets:25516
Count of transcripts:68250
Interacting mature miRNAs:hsa-miR-6735-3p, hsa-miR-6735-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system
High
Medium
Low 2 1 3
Below cutoff 1 1 7 1 2 4 1 1 1 4

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000615179
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl143,448,539 - 43,448,611 (+)Ensembl
RefSeq Acc Id: NR_106793
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38143,448,539 - 43,448,611 (+)NCBI
HuRef142,033,355 - 42,033,427 (+)NCBI
CHM1_1144,030,578 - 44,030,650 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p34.3-34.1(chr1:38222737-45636176)x3 copy number gain See cases [RCV000051803] Chr1:38222737..45636176 [GRCh38]
Chr1:38688409..46101848 [GRCh37]
Chr1:38460996..45874435 [NCBI36]
Chr1:1p34.3-34.1
pathogenic
GRCh38/hg38 1p34.2-34.1(chr1:40693289-44514104)x1 copy number loss See cases [RCV000050706] Chr1:40693289..44514104 [GRCh38]
Chr1:41158961..44979776 [GRCh37]
Chr1:40931548..44752363 [NCBI36]
Chr1:1p34.2-34.1
pathogenic
GRCh38/hg38 1p34.3-33(chr1:39479787-47688131)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051817]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051817]|See cases [RCV000051817] Chr1:39479787..47688131 [GRCh38]
Chr1:39945459..48153803 [GRCh37]
Chr1:39718046..47926390 [NCBI36]
Chr1:1p34.3-33
pathogenic
GRCh38/hg38 1p34.2-34.1(chr1:40462415-44668040)x1 copy number loss See cases [RCV000053837] Chr1:40462415..44668040 [GRCh38]
Chr1:40928087..45133712 [GRCh37]
Chr1:40700674..44906299 [NCBI36]
Chr1:1p34.2-34.1
pathogenic
NM_001365999.1(SZT2):c.9970-7C>G single nucleotide variant not provided [RCV000228267] Chr1:43448605 [GRCh38]
Chr1:43914276 [GRCh37]
Chr1:1p34.2
likely benign
NM_001365999.1(SZT2):c.9970-9C>T single nucleotide variant not provided [RCV000464156] Chr1:43448603 [GRCh38]
Chr1:43914274 [GRCh37]
Chr1:1p34.2
likely benign
NC_000001.11:g.(?_43446935)_(43450500_?)del deletion not provided [RCV000815275] Chr1:43446935..43450500 [GRCh38]
Chr1:43912606..43916171 [GRCh37]
Chr1:1p34.2
uncertain significance

Additional Information

Database Acc Id Source(s)
COSMIC MIR6735 COSMIC
Ensembl Genes ENSG00000274975 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000615179 ENTREZGENE
GTEx ENSG00000274975 GTEx
HGNC ID HGNC:50126 ENTREZGENE
Human Proteome Map MIR6735 Human Proteome Map
miRBase MI0022580 ENTREZGENE
NCBI Gene MIR6735 ENTREZGENE
RNAcentral URS000075AB2A RNACentral
  URS000075B9AD RNACentral
  URS000075ED0C RNACentral