MIR7843 (microRNA 7843) - Rat Genome Database

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Gene: MIR7843 (microRNA 7843) Homo sapiens
Analyze
Symbol: MIR7843
Name: microRNA 7843
RGD ID: 8550560
HGNC Page HGNC:50074
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-7843
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381472,516,820 - 72,516,898 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1472,516,820 - 72,516,898 (+)EnsemblGRCh38hg38GRCh38
GRCh371472,983,528 - 72,983,606 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map14q24.2NCBI
HuRef1453,150,049 - 53,150,127 (+)NCBIHuRef
CHM1_11472,921,544 - 72,921,622 (+)NCBICHM1_1
T2T-CHM13v2.01466,722,446 - 66,722,524 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:23226537   PMID:30232004  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 14q24.1-31.1(chr14:69562099-81975384)x1 copy number loss See cases [RCV000134154] Chr14:69562099..81975384 [GRCh38]
Chr14:70028816..82441728 [GRCh37]
Chr14:69098569..81511481 [NCBI36]
Chr14:14q24.1-31.1		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20151149-106855263)x3 copy number gain See cases [RCV000135543] Chr14:20151149..106855263 [GRCh38]
Chr14:20619308..107263478 [GRCh37]
Chr14:19689148..106334523 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q11.2-32.33(chr14:20043514-106877229)x3 copy number gain See cases [RCV000143373] Chr14:20043514..106877229 [GRCh38]
Chr14:20511673..107285437 [GRCh37]
Chr14:19581513..106356482 [NCBI36]
Chr14:14q11.2-32.33		 pathogenic
GRCh38/hg38 14q24.2(chr14:71647101-72567300)x3 copy number gain See cases [RCV000052082] Chr14:71647101..72567300 [GRCh38]
Chr14:72113818..73034008 [GRCh37]
Chr14:71183571..72103761 [NCBI36]
Chr14:14q24.2		 uncertain significance
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:61604
Count of gene targets:19561
Count of transcripts:47131
Interacting mature miRNAs:hsa-miR-7843-3p, hsa-miR-7843-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage entire extraembryonic component
High
Medium 4
Low 7 13 9 2 29 2 30 7 87 3 21 11 7 22
Below cutoff 6 11 8 10 1 22 17 58 2 12 11 7 15 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000622274
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl1472,516,820 - 72,516,898 (+)Ensembl
RefSeq Acc Id: NR_106994
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381472,516,820 - 72,516,898 (+)NCBI
HuRef1453,150,049 - 53,150,127 (+)NCBI
CHM1_11472,921,544 - 72,921,622 (+)NCBI
T2T-CHM13v2.01466,722,446 - 66,722,524 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR7843 COSMIC
Ensembl Genes ENSG00000273830 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000622274 ENTREZGENE
GTEx ENSG00000273830 GTEx
HGNC ID HGNC:50074 ENTREZGENE
Human Proteome Map MIR7843 Human Proteome Map
miRBase MI0025510 ENTREZGENE
NCBI Gene MIR7843 ENTREZGENE
RNAcentral URS000075A92E RNACentral
  URS000075D5E9 RNACentral
  URS000075E342 RNACentral