MIR6861 (microRNA 6861) - Rat Genome Database

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Gene: MIR6861 (microRNA 6861) Homo sapiens
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Symbol: MIR6861
Name: microRNA 6861
RGD ID: 8550545
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6861
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12112,163,258 - 112,163,321 (-)EnsemblGRCh38hg38GRCh38
GRCh3812112,163,258 - 112,163,321 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712112,601,062 - 112,601,125 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map12q24.13NCBI
HuRef12109,614,205 - 109,614,268 (-)NCBIHuRef
CHM1_112112,569,254 - 112,569,317 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:22955976  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:38869
Count of gene targets:16419
Count of transcripts:32599
Interacting mature miRNAs:hsa-miR-6861-3p, hsa-miR-6861-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage
High
Medium
Low 16 9 6 4 4 4 12 10 13 1 2 1 7 6
Below cutoff 3 2 1 1 1 1 9 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_106921 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC073575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000618657
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl12112,163,258 - 112,163,321 (-)Ensembl
RefSeq Acc Id: NR_106921
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh3812112,163,258 - 112,163,321 (-)NCBI
HuRef12109,614,205 - 109,614,268 (-)NCBI
CHM1_112112,569,254 - 112,569,317 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 12p13.33-q24.33(chr12:121271-133196807)x3 copy number gain See cases [RCV000139555] Chr12:121271..133196807 [GRCh38]
Chr12:282465..133773393 [GRCh37]
Chr12:100698..132283466 [NCBI36]
Chr12:12p13.33-q24.33
pathogenic
GRCh38/hg38 12q23.3-24.13(chr12:105234677-112194686)x1 copy number loss See cases [RCV000050807] Chr12:105234677..112194686 [GRCh38]
Chr12:105628455..112632490 [GRCh37]
Chr12:104152585..111116873 [NCBI36]
Chr12:12q23.3-24.13
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR6861 COSMIC
Ensembl Genes ENSG00000283793 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000618657 ENTREZGENE
GTEx ENSG00000283793 GTEx
HGNC ID HGNC:50129 ENTREZGENE
Human Proteome Map MIR6861 Human Proteome Map
miRBase MI0022708 ENTREZGENE
NCBI Gene MIR6861 ENTREZGENE
RNAcentral URS000075B829 RNACentral
  URS000075B892 RNACentral
  URS000075D08E RNACentral