MIR548AY (microRNA 548ay) - Rat Genome Database
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Gene: MIR548AY (microRNA 548ay) Homo sapiens
Analyze
Symbol: MIR548AY
Name: microRNA 548ay
RGD ID: 8550505
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-548ay
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl332,506,283 - 32,506,389 (-)EnsemblGRCh38hg38GRCh38
GRCh38332,506,283 - 32,506,389 (-)NCBIGRCh38GRCh38hg38GRCh38
Cytogenetic Map3p22.3NCBI
HuRef332,483,081 - 32,483,187 (-)NCBIHuRef
CHM1_1332,497,774 - 32,497,880 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:21807764  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:33024
Count of gene targets:10232
Count of transcripts:20842
Interacting mature miRNAs:hsa-miR-548ay-3p, hsa-miR-548ay-5p
Prediction methods:Microtar, Miranda, Pita, Pita,Targetscan, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium
Low 11 35 11 1 59 1 38 13 116 7 17 31 7 21 1
Below cutoff 63 101 38 9 127 5 98 59 271 10 44 47 4 25 58 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_106753 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC104306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000617669
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl332,506,283 - 32,506,389 (-)Ensembl
RefSeq Acc Id: NR_106753
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38332,506,283 - 32,506,389 (-)NCBI
HuRef332,483,081 - 32,483,187 (-)NCBI
CHM1_1332,497,774 - 32,497,880 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3p26.3-22.1(chr3:53308-41381521)x3 copy number gain See cases [RCV000141810] Chr3:53308..41381521 [GRCh38]
Chr3:94991..41423012 [GRCh37]
Chr3:69991..41398016 [NCBI36]
Chr3:3p26.3-22.1
pathogenic
GRCh38/hg38 3p22.3-22.2(chr3:32322382-36775606)x1 copy number loss See cases [RCV000051509] Chr3:32322382..36775606 [GRCh38]
Chr3:32363874..36817097 [GRCh37]
Chr3:32338878..36792101 [NCBI36]
Chr3:3p22.3-22.2
pathogenic
GRCh38/hg38 3p25.3-22.2(chr3:11463328-38919543)x3 copy number gain See cases [RCV000051720] Chr3:11463328..38919543 [GRCh38]
Chr3:11504802..38961034 [GRCh37]
Chr3:11479802..38936038 [NCBI36]
Chr3:3p25.3-22.2
pathogenic
GRCh38/hg38 3p26.3-22.2(chr3:52266-37148076)x3 copy number gain See cases [RCV000051097] Chr3:52266..37148076 [GRCh38]
Chr3:93949..37189567 [GRCh37]
Chr3:68949..37164571 [NCBI36]
Chr3:3p26.3-22.2
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR548AY COSMIC
Ensembl Genes ENSG00000276147 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000617669 ENTREZGENE
GTEx ENSG00000276147 GTEx
HGNC ID HGNC:49943 ENTREZGENE
Human Proteome Map MIR548AY Human Proteome Map
miRBase MI0022210 ENTREZGENE
NCBI Gene MIR548AY ENTREZGENE
RNAcentral URS000075B13F RNACentral
  URS000075D0C5 RNACentral
  URS000075EF99 RNACentral

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.