MIR6732 (microRNA 6732) - Rat Genome Database
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Gene: MIR6732 (microRNA 6732) Homo sapiens
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Symbol: MIR6732
Name: microRNA 6732
RGD ID: 8550270
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6732
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl137,480,230 - 37,480,289 (+)EnsemblGRCh38hg38GRCh38
GRCh38137,480,230 - 37,480,289 (+)NCBIGRCh38GRCh38hg38GRCh38
Cytogenetic Map1p34.3NCBI
HuRef136,062,875 - 36,062,934 (+)NCBIHuRef
CHM1_1138,061,958 - 38,062,017 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:22955976  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:75833
Count of gene targets:24129
Count of transcripts:62585
Interacting mature miRNAs:hsa-miR-6732-3p, hsa-miR-6732-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 36 63 22 10 40 3 138 19 18 3 32 41 7 29 68
Below cutoff 12 12 10 5 11 4 18 6 6 2 1 3 1 9 10

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_106790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AL034379 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000619365
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl137,480,230 - 37,480,289 (+)Ensembl
RefSeq Acc Id: NR_106790
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38137,480,230 - 37,480,289 (+)NCBI
HuRef136,062,875 - 36,062,934 (+)NCBI
CHM1_1138,061,958 - 38,062,017 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1p36.11-34.2(chr1:24381206-41401517)x3 copy number gain See cases [RCV000138891] Chr1:24381206..41401517 [GRCh38]
Chr1:24707696..41886350 [GRCh37]
Chr1:24580283..41658937 [NCBI36]
Chr1:1p36.11-34.2
pathogenic
GRCh38/hg38 1p34.3(chr1:37443860-37704418)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053658]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053658]|See cases [RCV000053658] Chr1:37443860..37704418 [GRCh38]
Chr1:37909461..38170090 [GRCh37]
Chr1:37682048..37942677 [NCBI36]
Chr1:1p34.3
benign

Additional Information

Database Acc Id Source(s)
COSMIC MIR6732 COSMIC
Ensembl Genes ENSG00000283724 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000619365 ENTREZGENE
GTEx ENSG00000283724 GTEx
HGNC ID HGNC:50066 ENTREZGENE
Human Proteome Map MIR6732 Human Proteome Map
miRBase MI0022577 ENTREZGENE
NCBI Gene MIR6732 ENTREZGENE
RNAcentral URS000075DB80 RNACentral
  URS000075DD0B RNACentral
  URS000075DED0 RNACentral