MIR6825 (microRNA 6825) - Rat Genome Database

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Pathways
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Gene: MIR6825 (microRNA 6825) Homo sapiens
Analyze
Symbol: MIR6825
Name: microRNA 6825
RGD ID: 8550259
HGNC Page HGNC:50208
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: hsa-mir-6825
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383127,575,266 - 127,575,331 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl3127,575,266 - 127,575,331 (-)EnsemblGRCh38hg38GRCh38
GRCh373127,294,109 - 127,294,174 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map3q21.3NCBI
HuRef3124,674,446 - 124,674,511 (-)NCBIHuRef
CHM1_13127,257,455 - 127,257,520 (-)NCBICHM1_1
T2T-CHM13v2.03130,309,931 - 130,309,996 (-)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:16381832   PMID:22955976   PMID:36030223  


Genomics


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29		 pathogenic
GRCh38/hg38 3q21.3(chr3:126797420-128946623)x1 copy number loss See cases [RCV000137444] Chr3:126797420..128946623 [GRCh38]
Chr3:126516263..128665466 [GRCh37]
Chr3:127998953..130148156 [NCBI36]
Chr3:3q21.3		 pathogenic|uncertain significance
GRCh38/hg38 3q13.2-21.3(chr3:112620977-128734134)x1 copy number loss See cases [RCV000139033] Chr3:112620977..128734134 [GRCh38]
Chr3:112339824..128452977 [GRCh37]
Chr3:113822514..129935667 [NCBI36]
Chr3:3q13.2-21.3		 pathogenic
GRCh38/hg38 3q21.3-23(chr3:126106779-140918089)x3 copy number gain See cases [RCV000142010] Chr3:126106779..140918089 [GRCh38]
Chr3:125825622..140636931 [GRCh37]
Chr3:127308312..142119621 [NCBI36]
Chr3:3q21.3-23		 uncertain significance
GRCh38/hg38 3q11.1-24(chr3:93800620-145695381)x3 copy number gain See cases [RCV000142340] Chr3:93800620..145695381 [GRCh38]
Chr3:93519464..145413168 [GRCh37]
Chr3:95002154..146895858 [NCBI36]
Chr3:3q11.1-24		 pathogenic
miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:76216
Count of gene targets:23253
Count of transcripts:58786
Interacting mature miRNAs:hsa-miR-6825-3p, hsa-miR-6825-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium 1 1 2 1
Low 33 40 38 11 37 8 52 18 57 10 35 44 5 10 36
Below cutoff 18 15 10 3 13 2 10 16 15 3 5 9 1 7 6

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000618505
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl3127,575,266 - 127,575,331 (-)Ensembl
RefSeq Acc Id: NR_106883
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383127,575,266 - 127,575,331 (-)NCBI
HuRef3124,674,446 - 124,674,511 (-)NCBI
CHM1_13127,257,455 - 127,257,520 (-)NCBI
T2T-CHM13v2.03130,309,931 - 130,309,996 (-)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
COSMIC MIR6825 COSMIC
Ensembl Genes ENSG00000275067 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000618505 ENTREZGENE
GTEx ENSG00000275067 GTEx
HGNC ID HGNC:50208 ENTREZGENE
Human Proteome Map MIR6825 Human Proteome Map
miRBase MI0022670 ENTREZGENE
NCBI Gene MIR6825 ENTREZGENE
RNAcentral URS0000759D52 RNACentral
  URS000075B4D3 RNACentral
  URS000075D5CF RNACentral