MIR6740 (microRNA 6740) - Rat Genome Database

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Gene: MIR6740 (microRNA 6740) Homo sapiens
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Symbol: MIR6740
Name: microRNA 6740
RGD ID: 8550179
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6740
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1202,003,124 - 202,003,236 (+)EnsemblGRCh38hg38GRCh38
GRCh381202,003,124 - 202,003,236 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371201,972,252 - 201,972,364 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map1q32.1NCBI
HuRef1173,138,140 - 173,138,252 (+)NCBIHuRef
CHM1_11203,394,499 - 203,394,611 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:22955976  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:35423
Count of gene targets:13250
Count of transcripts:26262
Interacting mature miRNAs:hsa-miR-6740-3p, hsa-miR-6740-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage entire extraembryonic component
High
Medium 1 1
Low 288 158 367 66 176 33 350 104 418 29 340 458 35 65 188 3
Below cutoff 459 361 327 118 261 69 546 280 625 52 236 289 53 158 310

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_106798 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC099676 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000618268
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1202,003,124 - 202,003,236 (+)Ensembl
RefSeq Acc Id: NR_106798
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381202,003,124 - 202,003,236 (+)NCBI
HuRef1173,138,140 - 173,138,252 (+)NCBI
CHM1_11203,394,499 - 203,394,611 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 1q32.1(chr1:200144603-203112078)x1 copy number loss See cases [RCV000133625] Chr1:200144603..203112078 [GRCh38]
Chr1:200113731..203081206 [GRCh37]
Chr1:198380354..201347829 [NCBI36]
Chr1:1q32.1
pathogenic
GRCh38/hg38 1q32.1(chr1:201226425-202014204)x3 copy number gain See cases [RCV000051558] Chr1:201226425..202014204 [GRCh38]
Chr1:201195553..201983332 [GRCh37]
Chr1:199462176..200249955 [NCBI36]
Chr1:1q32.1
uncertain significance
GRCh38/hg38 1q31.1-42.11(chr1:187143981-224299417)x3 copy number gain See cases [RCV000051857] Chr1:187143981..224299417 [GRCh38]
Chr1:187113113..224487119 [GRCh37]
Chr1:185379736..222553742 [NCBI36]
Chr1:1q31.1-42.11
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR6740 COSMIC
Ensembl Genes ENSG00000275207 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000618268 ENTREZGENE
GTEx ENSG00000275207 GTEx
HGNC ID HGNC:50082 ENTREZGENE
Human Proteome Map MIR6740 Human Proteome Map
miRBase MI0022585 ENTREZGENE
NCBI Gene MIR6740 ENTREZGENE
RNAcentral URS000075CDE3 RNACentral
  URS000075D24A RNACentral
  URS000075E833 RNACentral