MIR4433B (microRNA 4433b) - Rat Genome Database
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Gene: MIR4433B (microRNA 4433b) Homo sapiens
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Symbol: MIR4433B
Name: microRNA 4433b
RGD ID: 8550169
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-4433b
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl264,340,747 - 64,340,848 (-)EnsemblGRCh38hg38GRCh38
GRCh38264,340,747 - 64,340,848 (-)NCBIGRCh38GRCh38hg38GRCh38
Cytogenetic Map2p14NCBI
HuRef264,302,766 - 64,302,867 (-)NCBIHuRef
CHM1_1264,498,496 - 64,498,597 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
paracetamol  (EXP)

References
Additional References at PubMed
PMID:16381832   PMID:23226537   PMID:26646931  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:42622
Count of gene targets:15661
Count of transcripts:33928
Interacting mature miRNAs:hsa-miR-4433b-3p, hsa-miR-4433b-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1
Low 4 3 3 33 3 11 5 12 2
Below cutoff 1 2 1 2 1 1 3 3 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_106995 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC114752 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000581329
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl264,340,747 - 64,340,848 (-)Ensembl
RefSeq Acc Id: NR_106995
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38264,340,747 - 64,340,848 (-)NCBI
HuRef264,302,766 - 64,302,867 (-)NCBI
CHM1_1264,498,496 - 64,498,597 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 2p16.1-11.2(chr2:58279519-83586962)x3 copy number gain See cases [RCV000136053] Chr2:58279519..83586962 [GRCh38]
Chr2:58506654..83814086 [GRCh37]
Chr2:58360158..83667597 [NCBI36]
Chr2:2p16.1-11.2
pathogenic
GRCh38/hg38 2p16.3-11.2(chr2:47620388-86702722)x3 copy number gain See cases [RCV000137586] Chr2:47620388..86702722 [GRCh38]
Chr2:47847527..86929845 [GRCh37]
Chr2:47701031..86783356 [NCBI36]
Chr2:2p16.3-11.2
uncertain significance
GRCh38/hg38 2p25.1-11.2(chr2:7495123-87705899)x3 copy number gain See cases [RCV000141494] Chr2:7495123..87705899 [GRCh38]
Chr2:7635254..88005418 [GRCh37]
Chr2:7552705..87786533 [NCBI36]
Chr2:2p25.1-11.2
benign
GRCh38/hg38 2p15-14(chr2:63311999-67309291)x1 copy number loss See cases [RCV000054054] Chr2:63311999..67309291 [GRCh38]
Chr2:63539134..67536423 [GRCh37]
Chr2:63392638..67389927 [NCBI36]
Chr2:2p15-14
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR4433B COSMIC
Ensembl Genes ENSG00000264297 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000581329 ENTREZGENE
GTEx ENSG00000264297 GTEx
HGNC ID HGNC:50258 ENTREZGENE
Human Proteome Map MIR4433B Human Proteome Map
miRBase MI0025511 ENTREZGENE
NCBI Gene MIR4433B ENTREZGENE
RNAcentral URS0000759BCF RNACentral
  URS000075A912 RNACentral
  URS000075CAA8 RNACentral