MIR6748 (microRNA 6748) - Rat Genome Database
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Gene: MIR6748 (microRNA 6748) Homo sapiens
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Symbol: MIR6748
Name: microRNA 6748
RGD ID: 8550109
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6748
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1162,789,815 - 62,789,885 (+)EnsemblGRCh38hg38GRCh38
GRCh381162,789,815 - 62,789,885 (+)NCBIGRCh38GRCh38hg38GRCh38
Cytogenetic Map11q12.3NCBI
HuRef1158,886,313 - 58,886,383 (+)NCBIHuRef
CHM1_11162,440,369 - 62,440,439 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:22955976  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:61015
Count of gene targets:19815
Count of transcripts:48106
Interacting mature miRNAs:hsa-miR-6748-3p, hsa-miR-6748-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system adipose tissue appendage
High
Medium
Low 70 59 78 7 48 5 106 42 84 3 53 63 2 34 66
Below cutoff 17 31 17 4 9 4 22 27 53 3 5 7 10 16

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_106806 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AP001160 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000610433
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1162,789,815 - 62,789,885 (+)Ensembl
RefSeq Acc Id: NR_106806
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381162,789,815 - 62,789,885 (+)NCBI
HuRef1158,886,313 - 58,886,383 (+)NCBI
CHM1_11162,440,369 - 62,440,439 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 11q12.3(chr11:62562836-62840570)x3 copy number gain See cases [RCV000134807] Chr11:62562836..62840570 [GRCh38]
Chr11:62330308..62608042 [GRCh37]
Chr11:62086884..62364618 [NCBI36]
Chr11:11q12.3
uncertain significance
GRCh38/hg38 11q12.3(chr11:62249520-62946093)x3 copy number gain See cases [RCV000138411] Chr11:62249520..62946093 [GRCh38]
Chr11:62016992..62713565 [GRCh37]
Chr11:61773568..62470141 [NCBI36]
Chr11:11q12.3
pathogenic
GRCh38/hg38 11q12.3(chr11:62433886-63096003)x3 copy number gain See cases [RCV000053620] Chr11:62433886..63096003 [GRCh38]
Chr11:62201358..62863475 [GRCh37]
Chr11:61957934..62620051 [NCBI36]
Chr11:11q12.3
pathogenic
GRCh38/hg38 11q12.3(chr11:62452571-62862781)x3 copy number gain See cases [RCV000053621] Chr11:62452571..62862781 [GRCh38]
Chr11:62220043..62630253 [GRCh37]
Chr11:61976619..62386829 [NCBI36]
Chr11:11q12.3
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR6748 COSMIC
Ensembl Genes ENSG00000284535 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000610433 ENTREZGENE
GTEx ENSG00000284535 GTEx
HGNC ID HGNC:50141 ENTREZGENE
Human Proteome Map MIR6748 Human Proteome Map
miRBase MI0022593 ENTREZGENE
NCBI Gene MIR6748 ENTREZGENE
RNAcentral URS000075D023 RNACentral
  URS000075E2F1 RNACentral
  URS000075ECB7 RNACentral