MIR1199 (microRNA 1199) - Rat Genome Database
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Gene: MIR1199 (microRNA 1199) Homo sapiens
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Symbol: MIR1199
Name: microRNA 1199
RGD ID: 8550032
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-1199
RGD Orthologs
Mouse
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1914,073,361 - 14,073,479 (+)EnsemblGRCh38hg38GRCh38
GRCh381914,073,361 - 14,073,479 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371914,184,173 - 14,184,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map19p13.12NCBI
HuRef1913,755,831 - 13,755,949 (+)NCBIHuRef
CHM1_11914,184,744 - 14,184,862 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:23229173  


Genomics

Comparative Map Data
MIR1199
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1914,073,361 - 14,073,479 (+)EnsemblGRCh38hg38GRCh38
GRCh381914,073,361 - 14,073,479 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371914,184,173 - 14,184,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map19p13.12NCBI
HuRef1913,755,831 - 13,755,949 (+)NCBIHuRef
CHM1_11914,184,744 - 14,184,862 (+)NCBICHM1_1
Mir1199
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39884,738,144 - 84,738,262 (-)NCBIGRCm39mm39
GRCm39 Ensembl884,738,144 - 84,738,262 (-)Ensembl
GRCm38884,011,515 - 84,011,633 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl884,011,515 - 84,011,633 (-)EnsemblGRCm38mm10GRCm38
Celera888,304,650 - 88,304,768 (-)NCBICelera
Cytogenetic Map8C2NCBI
cM Map840.24NCBI

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:49676
Count of gene targets:18155
Count of transcripts:42737
Interacting mature miRNAs:hsa-miR-1199-3p, hsa-miR-1199-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NR_106715 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AC022098 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000621445
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1914,073,361 - 14,073,479 (+)Ensembl
RefSeq Acc Id: NR_106715
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381914,073,361 - 14,073,479 (+)NCBI
HuRef1913,755,831 - 13,755,949 (+)NCBI
CHM1_11914,184,744 - 14,184,862 (+)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 19p13.2-q13.31(chr19:11227942-44626354)x3 copy number gain See cases [RCV000133888] Chr19:11227942..44626354 [GRCh38]
Chr19:11338618..45129651 [GRCh37]
Chr19:11199618..49821491 [NCBI36]
Chr19:19p13.2-q13.31
pathogenic
GRCh38/hg38 19p13.13-13.12(chr19:13533925-15371089)x1 copy number loss See cases [RCV000136502] Chr19:13533925..15371089 [GRCh38]
Chr19:13644739..15481900 [GRCh37]
Chr19:13505739..15342900 [NCBI36]
Chr19:19p13.13-13.12
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:12580427-14742673)x1 copy number loss See cases [RCV000135937] Chr19:12580427..14742673 [GRCh38]
Chr19:12691241..14853485 [GRCh37]
Chr19:12552241..14714485 [NCBI36]
Chr19:19p13.2-13.12
pathogenic|likely pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11525163-14155021)x1 copy number loss See cases [RCV000136909] Chr19:11525163..14155021 [GRCh38]
Chr19:11635978..14265833 [GRCh37]
Chr19:11496978..14126833 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.13-13.12(chr19:13533925-14258833)x1 copy number loss See cases [RCV000051051] Chr19:13533925..14258833 [GRCh38]
Chr19:13644739..14369645 [GRCh37]
Chr19:13505739..14230645 [NCBI36]
Chr19:19p13.13-13.12
uncertain significance
GRCh38/hg38 19p13.2-13.12(chr19:12132052-14751798)x3 copy number gain See cases [RCV000052910] Chr19:12132052..14751798 [GRCh38]
Chr19:12242867..14862610 [GRCh37]
Chr19:12103867..14723610 [NCBI36]
Chr19:19p13.2-13.12
pathogenic
GRCh38/hg38 19p13.12-q11(chr19:13974677-27839676)x3 copy number gain See cases [RCV000052912] Chr19:13974677..27839676 [GRCh38]
Chr19:14085489..28330584 [GRCh37]
Chr19:13946489..33022424 [NCBI36]
Chr19:19p13.12-q11
pathogenic
GRCh38/hg38 19p13.2-13.12(chr19:11227942-14532135)x1 copy number loss Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000053944]|See cases [RCV000053944] Chr19:11227942..14532135 [GRCh38]
Chr19:11338618..14642947 [GRCh37]
Chr19:11199618..14503947 [NCBI36]
Chr19:19p13.2-13.12
pathogenic

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:50081 AgrOrtholog
COSMIC MIR1199 COSMIC
Ensembl Genes ENSG00000284081 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000621445 ENTREZGENE
GTEx ENSG00000284081 GTEx
HGNC ID HGNC:50081 ENTREZGENE
Human Proteome Map MIR1199 Human Proteome Map
miRBase MI0020340 ENTREZGENE
NCBI Gene MIR1199 ENTREZGENE
RNAcentral URS000075B871 RNACentral
  URS000075DBCC RNACentral
  URS000075F0BC RNACentral