MIR6868 (microRNA 6868) - Rat Genome Database

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Gene: MIR6868 (microRNA 6868) Homo sapiens
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Symbol: MIR6868
Name: microRNA 6868
RGD ID: 8550012
HGNC Page HGNC
Description: microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Type: ncrna
RefSeq Status: PROVISIONAL
Also known as: hsa-mir-6868
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1776,098,019 - 76,098,076 (-)EnsemblGRCh38hg38GRCh38
GRCh381776,098,019 - 76,098,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371774,094,100 - 74,094,157 (-)NCBIGRCh37GRCh37hg19GRCh37
Cytogenetic Map17q25.1NCBI
HuRef1769,523,028 - 69,523,085 (-)NCBIHuRef
CHM1_11774,159,005 - 74,159,062 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


References
Additional References at PubMed
PMID:16381832   PMID:22955976   PMID:30486864  


Genomics

miRNA Target Status

Predicted Targets
Summary Value
Count of predictions:50197
Count of gene targets:16179
Count of transcripts:35952
Interacting mature miRNAs:hsa-miR-6868-3p, hsa-miR-6868-5p
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system adipose tissue appendage
High
Medium
Low 9 9 8 18 15 6 6 2 8 14 3 7
Below cutoff 3 1 1 20 1 5 6 13 5 5 7 1

Sequence


Reference Sequences
RefSeq Acc Id: ENST00000611215
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl1776,098,019 - 76,098,076 (-)Ensembl
RefSeq Acc Id: NR_106928
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh381776,098,019 - 76,098,076 (-)NCBI
HuRef1769,523,028 - 69,523,085 (-)NCBI
CHM1_11774,159,005 - 74,159,062 (-)NCBI
Sequence:

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 17q24.3-25.3(chr17:69916435-83102552)x3 copy number gain See cases [RCV000143342] Chr17:69916435..83102552 [GRCh38]
Chr17:67912576..81048189 [GRCh37]
Chr17:65424171..78653717 [NCBI36]
Chr17:17q24.3-25.3
pathogenic
GRCh38/hg38 17q23.2-25.3(chr17:36449220-83086677)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000052483]|See cases [RCV000052483] Chr17:36449220..83086677 [GRCh38]
Chr17:58617905..81044553 [GRCh37]
Chr17:55972687..78637842 [NCBI36]
Chr17:17q23.2-25.3
pathogenic
GRCh38/hg38 17q24.3-25.3(chr17:69209079-83086677)x3 copy number gain See cases [RCV000052486] Chr17:69209079..83086677 [GRCh38]
Chr17:67205220..81044553 [GRCh37]
Chr17:64716815..78637842 [NCBI36]
Chr17:17q24.3-25.3
pathogenic

Additional Information

Database Acc Id Source(s)
COSMIC MIR6868 COSMIC
Ensembl Genes ENSG00000275360 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000611215 ENTREZGENE
GTEx ENSG00000275360 GTEx
HGNC ID HGNC:50096 ENTREZGENE
Human Proteome Map MIR6868 Human Proteome Map
miRBase MI0022715 ENTREZGENE
NCBI Gene MIR6868 ENTREZGENE
RNAcentral URS000075CE71 RNACentral
  URS000075DF84 RNACentral
  URS000075EE35 RNACentral