Cmc4 (C-X9-C motif containing 4) - Rat Genome Database

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Gene: Cmc4 (C-X9-C motif containing 4) Rattus norvegicus
Analyze
Symbol: Cmc4
Name: C-X9-C motif containing 4
RGD ID: 7647017
Description: Predicted to be located in mitochondrion. Orthologous to human CMC4 (C-X9-C motif containing 4); INTERACTS WITH aflatoxin B1 (ortholog); benzo[a]pyrene (ortholog); bisphenol A (ortholog).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: cx9C motif-containing protein 4; cx9C motif-containing protein 4-like; LOC102546764
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr818139,382 - 147,037 (+)NCBIGRCr8
mRatBN7.218125,308 - 132,163 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl18125,227 - 132,160 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx18137,523 - 143,916 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018925,364 - 931,757 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.018139,432 - 145,825 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.018407,517 - 414,110 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18408,219 - 410,098 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.018453,285 - 459,145 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera18119,279 - 125,719 (+)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

References

References - curated
# Reference Title Reference Citation
1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
2. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:15632090  


Genomics

Comparative Map Data
Cmc4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr818139,382 - 147,037 (+)NCBIGRCr8
mRatBN7.218125,308 - 132,163 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl18125,227 - 132,160 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx18137,523 - 143,916 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.018925,364 - 931,757 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.018139,432 - 145,825 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.018407,517 - 414,110 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl18408,219 - 410,098 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.018453,285 - 459,145 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera18119,279 - 125,719 (+)NCBICelera
Cytogenetic Map18p13NCBI
CMC4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38X155,061,622 - 155,071,136 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 EnsemblX155,061,622 - 155,071,136 (-)EnsemblGRCh38hg38GRCh38
GRCh37X154,289,897 - 154,299,411 (-)NCBIGRCh37GRCh37hg19GRCh37
CeleraX154,448,614 - 154,458,264 (-)NCBICelera
Cytogenetic MapXq28NCBI
HuRefX142,835,131 - 142,844,484 (-)NCBIHuRef
CHM1_1X154,201,524 - 154,211,174 (-)NCBICHM1_1
T2T-CHM13v2.0X153,298,030 - 153,307,544 (-)NCBIT2T-CHM13v2.0
Cmc4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X74,448,452 - 74,460,190 (-)NCBIGRCm39GRCm39mm39
GRCm39 EnsemblX74,448,452 - 74,460,190 (-)EnsemblGRCm39 Ensembl
GRCm38X75,404,846 - 75,416,584 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX75,404,846 - 75,416,584 (-)EnsemblGRCm38mm10GRCm38
Cytogenetic MapXA7.3NCBI
Cmc4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_004955594618,516 - 624,780 (+)EnsemblChiLan1.0
ChiLan1.0NW_004955594618,516 - 624,780 (+)NCBIChiLan1.0ChiLan1.0
CMC4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v2X155,039,550 - 155,048,971 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan1X155,038,400 - 155,052,579 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v0X144,540,603 - 144,550,152 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.1X154,379,475 - 154,388,932 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX154,379,485 - 154,388,932 (-)Ensemblpanpan1.1panPan2
CMC4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1X123,071,076 - 123,080,799 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Dog10K_Boxer_TashaX108,064,456 - 108,074,186 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0X126,198,629 - 126,208,364 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 EnsemblX126,198,634 - 126,208,364 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1X121,946,517 - 121,956,248 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0X124,468,959 - 124,478,687 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0X124,189,658 - 124,199,387 (-)NCBIUU_Cfam_GSD_1.0
Cmc4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2X119,964,268 - 119,982,416 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_004936927320,833 - 341,021 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_004936927317,417 - 341,016 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CMC4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,372,941 - 125,376,999 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,372,941 - 125,383,272 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,099,933 - 143,110,085 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CMC4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1X129,348,831 - 129,358,601 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 EnsemblX129,349,054 - 129,351,326 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366606567,326,930 - 67,336,667 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cmc4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_004624963212,030 - 221,697 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_004624963212,470 - 221,697 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cmc4
75 total Variants

QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
8552968Pigfal19Plasma insulin-like growth factor 1 level QTL 1911.4blood insulin-like growth factor amount (VT:0010479)plasma insulin-like growth factor 1 level (CMO:0001299)18125758124Rat
9590248Scort10Serum corticosterone level QTL 1019.710.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)18125758124Rat
2312598Bp340Blood pressure QTL 3400.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)18130558703Rat
2300180Bmd67Bone mineral density QTL 674.80.0001femur mineral mass (VT:0010011)bone mineral density (CMO:0001226)18134291613Rat
2293661Bss50Bone structure and strength QTL 504.640.0003lumbar vertebra size trait (VT:0010518)lumbar vertebra trabecular cross-sectional area (CMO:0001692)18134291613Rat
61388Bp2Blood pressure QTL 23.23arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)18135374722Rat
9589153Insul31Insulin level QTL 317.150.05blood insulin amount (VT:0001560)plasma insulin level (CMO:0000342)18142547119Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 3 34 43 31 19 31 1 4 73 34 41 11 1
Low 9 14 10 10 7 7 1 1 7
Below cutoff

Sequence


RefSeq Acc Id: ENSRNOT00000084138   ⟹   ENSRNOP00000072400
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl18125,227 - 132,160 (+)Ensembl
Rnor_6.0 Ensembl18408,219 - 410,098 (-)Ensembl
RefSeq Acc Id: NM_001400848   ⟹   NP_001387777
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818140,121 - 146,519 (+)NCBI
mRatBN7.218125,765 - 132,163 (+)NCBI
RefSeq Acc Id: XM_006254392   ⟹   XP_006254454
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818143,308 - 147,037 (+)NCBI
mRatBN7.218128,721 - 132,163 (+)NCBI
Rnor_6.018407,517 - 411,234 (-)NCBI
Rnor_5.018453,285 - 459,145 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039097393   ⟹   XP_038953321
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr818139,382 - 147,037 (+)NCBI
mRatBN7.218125,308 - 132,163 (+)NCBI
Protein Sequences
Protein RefSeqs NP_001387777 (Get FASTA)   NCBI Sequence Viewer  
  XP_006254454 (Get FASTA)   NCBI Sequence Viewer  
  XP_038953321 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL86648 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000072400.2
RefSeq Acc Id: XP_006254454   ⟸   XM_006254392
- Peptide Label: isoform X2
- UniProtKB: A6KNC3 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSRNOP00000072400   ⟸   ENSRNOT00000084138
RefSeq Acc Id: XP_038953321   ⟸   XM_039097393
- Peptide Label: isoform X1
RefSeq Acc Id: NP_001387777   ⟸   NM_001400848
- UniProtKB: A6KNC3 (UniProtKB/TrEMBL)

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-A0A0G2K2W2-F1-model_v2 AlphaFold A0A0G2K2W2 1-68 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:7647017 AgrOrtholog
BioCyc Gene G2FUF-8443 BioCyc
Ensembl Genes ENSRNOG00000056435 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000084138.2 UniProtKB/TrEMBL
Gene3D-CATH CytochromE C oxidase copper chaperone UniProtKB/TrEMBL
InterPro Cys_alpha_HP_mot_SF UniProtKB/TrEMBL
  MTCP1 UniProtKB/TrEMBL
KEGG Report rno:102546764 UniProtKB/TrEMBL
NCBI Gene LOC102546764 ENTREZGENE
PANTHER CX9C MOTIF-CONTAINING PROTEIN 4 UniProtKB/TrEMBL
  PTHR15590 UniProtKB/TrEMBL
Pfam MTCP1 UniProtKB/TrEMBL
PhenoGen Cmc4 PhenoGen
PROSITE CHCH UniProtKB/TrEMBL
RatGTEx ENSRNOG00000056435 RatGTEx
Superfamily-SCOP SSF47072 UniProtKB/TrEMBL
UniProt A0A0G2K2W2_RAT UniProtKB/TrEMBL
  A6KNC3 ENTREZGENE, UniProtKB/TrEMBL


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2018-09-05 Cmc4  C-X9-C motif containing 4  LOC102546764  cx9C motif-containing protein 4-like  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2013-12-18 LOC102546764  cx9C motif-containing protein 4-like      Symbol and Name status set to provisional 70820 PROVISIONAL