Ulbp1 (UL16 binding protein 1) - Rat Genome Database

Name: Ulbp1
Creator: Rat Genome Database
License: Creative Commons CC BY 4.0
Keywords: Rat Gene RGD Genome

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Gene: Ulbp1 (UL16 binding protein 1) Rattus norvegicus

Analyze

Symbol:

Ulbp1

Name:

UL16 binding protein 1

RGD ID:

7509852

Description:

Predicted to enable natural killer cell lectin-like receptor binding activity. Predicted to be involved in natural killer cell activation and natural killer cell mediated cytotoxicity. Predicted to act upstream of or within several processes, including positive regulation of immune response; positive regulation of leukocyte activation; and positive regulation of nitric oxide biosynthetic process. Predicted to be located in cytosol and external side of plasma membrane. Orthologous to several human genes including ULBP2 (UL16 binding protein 2); RAET1E (retinoic acid early transcript 1E); and RAET1L (retinoic acid early transcript 1L); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; rotenone; silicon dioxide.

Type:

protein-coding

RefSeq Status:

MODEL

Previously known as:

histocompatibility antigen 60b-like; LOC102547056; retinoic acid early-inducible protein 1-gamma-like

RGD Orthologs

Human

Mouse

Bonobo

Green Monkey

Alliance Genes

More Info

more info ...

Latest Assembly:

mRatBN7.2 - mRatBN7.2 Assembly

Position:

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	1,694,255 - 1,716,160 (+)	NCBI	mRatBN7.2	mRatBN7.2
Rnor_6.0	1	1,181,301 - 1,200,526 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	1,180,932 - 1,220,916 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	2,908,847 - 2,910,387 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	1	393,918 - 415,841 (+)	NCBI		Celera
Cytogenetic Map	1	p13	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

Disease Annotations Click to see Annotation Detail View

genetic disease (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

17beta-estradiol (ISO)

2,2',4,4',5,5'-hexachlorobiphenyl (ISO)

2,2',5,5'-tetrachlorobiphenyl (ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2-hydroxypropanoic acid (ISO)

3,3',5,5'-tetrabromobisphenol A (ISO)

acrylamide (ISO)

all-trans-retinoic acid (ISO)

arsenite(3-) (ISO)

arsenous acid (ISO)

benzo[a]pyrene diol epoxide I (ISO)

bisphenol A (ISO)

butanal (ISO)

carbon nanotube (ISO)

chlordecone (ISO)

chloropicrin (ISO)

D-mannitol (ISO)

diarsenic trioxide (ISO)

dimethylarsinic acid (ISO)

erlotinib hydrochloride (ISO)

gefitinib (ISO)

Goe 6976 (ISO)

hydralazine (ISO)

Licochalcone B (ISO)

methylarsonic acid (ISO)

methylisothiazolinone (ISO)

N-methyl-4-phenylpyridinium (ISO)

paracetamol (ISO)

PCB138 (ISO)

pentanal (ISO)

phorbol 13-acetate 12-myristate (ISO)

potassium chromate (ISO)

propanal (ISO)

protein kinase inhibitor (ISO)

prothioconazole (ISO)

quercetin (ISO)

rac-lactic acid (ISO)

resveratrol (ISO)

rotenone (EXP)

rottlerin (ISO)

silicon dioxide (EXP)

sodium arsenate (ISO)

sodium arsenite (ISO)

sunitinib (ISO)

temozolomide (ISO)

thapsigargin (ISO)

triptonide (ISO)

tunicamycin (ISO)

valproic acid (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

natural killer cell activation (ISO)

natural killer cell mediated cytotoxicity (ISO)

positive regulation of immune response to tumor cell (ISO)

positive regulation of macrophage activation (ISO)

positive regulation of natural killer cell activation (ISO)

positive regulation of nitric oxide biosynthetic process (ISO)

positive regulation of type II interferon production (ISO)

susceptibility to natural killer cell mediated cytotoxicity (ISO)

Cellular Component

cytosol (ISO)

external side of plasma membrane (ISO)

obsolete anchored component of plasma membrane (ISO)

plasma membrane (ISO)

Molecular Function

natural killer cell lectin-like receptor binding (ISO)

protein binding (ISO)

References

References - curated

#	Reference Title	Reference Citation
1.	Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium.	Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.

Additional References at PubMed

PMID:11239445	PMID:12645935	PMID:18676862

Genomics

Comparative Map Data

Ulbp1
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
mRatBN7.2	1	1,694,255 - 1,716,160 (+)	NCBI	mRatBN7.2	mRatBN7.2
Rnor_6.0	1	1,181,301 - 1,200,526 (+)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	1,180,932 - 1,220,916 (+)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	2,908,847 - 2,910,387 (+)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
Celera	1	393,918 - 415,841 (+)	NCBI		Celera
Cytogenetic Map	1	p13	NCBI

ULBP1
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	6	149,963,943 - 149,973,715 (+)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p13 Ensembl	6	149,963,943 - 149,973,715 (+)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	6	150,285,079 - 150,294,851 (+)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	6	150,326,836 - 150,336,539 (+)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	6	150,377,256 - 150,386,958	NCBI
Celera	6	151,019,759 - 151,029,462 (+)	NCBI		Celera
Cytogenetic Map	6	q25.1	NCBI
HuRef	6	147,850,624 - 147,860,327 (+)	NCBI		HuRef
CHM1_1	6	150,549,752 - 150,559,455 (+)	NCBI		CHM1_1
T2T-CHM13v2.0	6	151,163,286 - 151,173,058 (+)	NCBI		T2T-CHM13v2.0

Ulbp1
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	10	7,394,873 - 7,423,643 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	10	7,390,362 - 7,423,638 (-)	Ensembl		GRCm39 Ensembl
GRCm38	10	7,444,873 - 7,473,641 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	10	7,440,362 - 7,473,638 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv36	10	21,913,473 - 21,944,572 (+)	NCBI		MGSCv36	mm8
Celera	10	7,404,171 - 7,432,757 (-)	NCBI		Celera
Cytogenetic Map	10	A1	NCBI

LOC100986963
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
PanPan1.1	6	152,477,350 - 152,486,911 (+)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	6	152,477,350 - 152,486,911 (+)	Ensembl	panpan1.1		panPan2
Mhudiblu_PPA_v0	6	147,798,494 - 147,811,888 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3

LOC103240141
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	13	21,625,381 - 21,638,933 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	13	21,629,092 - 21,636,623 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666241	61,719 - 71,242 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Variants

Variants in Ulbp1
404 total Variants

QTLs in Region (mRatBN7.2)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
1354647	Despr8	Despair related QTL 8		0.0000341	locomotor behavior trait (VT:0001392)	amount of experiment time spent in a discrete space in an experimental apparatus (CMO:0000958)	1	1	24744506	Rat
2298546	Neuinf4	Neuroinflammation QTL 4	5.1		nervous system integrity trait (VT:0010566)	spinal cord RT1-B protein level (CMO:0002132)	1	1	28736750	Rat
2313053	Bss51	Bone structure and strength QTL 51	3.8	0.0001	tibia length (VT:0004357)	tibia length (CMO:0000450)	1	1	32356093	Rat
2313070	Bss52	Bone structure and strength QTL 52	4.4	0.0001	body length (VT:0001256)	body length (CMO:0000013)	1	1	32356093	Rat
2313090	Bmd69	Bone mineral density QTL 69	4.4	0.0001	tibia mineral mass (VT:1000283)	compact volumetric bone mineral density (CMO:0001730)	1	1	32356093	Rat
738020	Pia8	Pristane induced arthritis QTL 8	4.7		joint integrity trait (VT:0010548)	joint inflammation composite score (CMO:0000919)	1	1	65833076	Rat
1578650	Bmd6	Bone mineral density QTL 6	12.2		femur mineral mass (VT:0010011)	total volumetric bone mineral density (CMO:0001728)	1	509108	43284926	Rat
1578651	Bmd7	Bone mineral density QTL 7	14.2		femur mineral mass (VT:0010011)	compact volumetric bone mineral density (CMO:0001730)	1	509108	43284926	Rat
1578669	Bss9	Bone structure and strength QTL 9	6.3		femur morphology trait (VT:0000559)	bone trabecular cross-sectional area (CMO:0002311)	1	509108	43284926	Rat
1554320	Bmd1	Bone mineral density QTL 1	12.2	0.0001	femur mineral mass (VT:0010011)	volumetric bone mineral density (CMO:0001553)	1	509108	86060548	Rat

Expression

RNA-SEQ Expression

High: > 1000 TPM value Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM Below Cutoff: < 0.5 TPM

	alimentary part of gastrointestinal system	circulatory system	endocrine system	exocrine system	hemolymphoid system	hepatobiliary system	integumental system	musculoskeletal system	nervous system	renal system	reproductive system	respiratory system	appendage
High
Medium		18								8	6	1
Low	3	25	46	30	19	30	8	11	15	26	28	10	8
Below cutoff			10	10		10			57	1	6

View RNA-SEQ Expression Data

Sequence

Nucleotide Sequences


RefSeq Transcripts	XM_017588645	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_017590411	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_039098404	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XR_005497168	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	JACYVU010000007	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Reference Sequences

RefSeq Acc Id:

ENSRNOT00000087443 ⟹ ENSRNOP00000073465

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
Rnor_6.0 Ensembl	1	1,180,932 - 1,220,916 (+)	Ensembl

RefSeq Acc Id:

XM_039098404 ⟹ XP_038954332

RefSeq Status:

Type:

CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	1,694,255 - 1,716,160 (+)	NCBI

RefSeq Acc Id:

XR_005497168

RefSeq Status:

Type:

NON-CODING

Position:

Rat Assembly	Chr	Position (strand)	Source
mRatBN7.2	1	1,694,688 - 1,716,160 (+)	NCBI

Protein Sequences


Protein RefSeqs	XP_038954332	(Get FASTA)	NCBI Sequence Viewer

Reference Sequences

RefSeq Acc Id:

ENSRNOP00000073465 ⟸ ENSRNOT00000087443

RefSeq Acc Id:

XP_038954332 ⟸ XM_039098404

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-A0A0G2K5L0-F1-model_v2	AlphaFold	A0A0G2K5L0	1-255	view protein structure

Transcriptome

eQTL		View at Phenogen
WGCNA		View at Phenogen
Tissue/Strain Expression		View at Phenogen

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	RGD:7509852	AgrOrtholog
BioCyc Gene	G2FUF-62472	BioCyc
Ensembl Genes	ENSRNOG00000061316	Ensembl
NCBI Gene	LOC102547056	ENTREZGENE
PhenoGen	Ulbp1	PhenoGen

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2019-05-24	Ulbp1	UL16 binding protein 1	LOC102547056	retinoic acid early-inducible protein 1-gamma-like	Nomenclature updated to reflect human and mouse nomenclature	1299863	APPROVED
2013-12-17	LOC102547056	retinoic acid early-inducible protein 1-gamma-like			Symbol and Name status set to provisional	70820	PROVISIONAL

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

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