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Gene: YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta) Homo sapiens
Symbol: YWHAB
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
RGD ID: 737527
Description: Exhibits several functions, including histone deacetylase binding activity; identical protein binding activity; and phosphoserine residue binding activity. Involved in several processes, including cytoplasmic sequestering of protein; negative regulation of G protein-coupled receptor signaling pathway; and negative regulation of protein dephosphorylation. Localizes to cytosol and perinuclear region of cytoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 14-3-3 alpha; 14-3-3 protein beta/alpha; brain protein 14-3-3, beta isoform; epididymis secretory protein Li 1; GW128; HEL-S-1; HS1; KCIP-1; protein 1054; protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxgenase/tryptophan 5 monooxgenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; YWHAA
Related Pseudogenes: YWHABP1   YWHABP2  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl2044,885,702 - 44,908,532 (+)EnsemblGRCh38hg38GRCh38
GRCh382044,885,705 - 44,908,532 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh372043,514,240 - 43,537,173 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 362042,947,758 - 42,970,575 (+)NCBINCBI36hg18NCBI36
Build 342042,947,757 - 42,970,574NCBI
Celera2040,222,982 - 40,245,799 (+)NCBI
Cytogenetic Map20q13.12NCBI
HuRef2040,256,131 - 40,279,005 (+)NCBIHuRef
CHM1_12043,417,179 - 43,440,099 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on YWHAB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737527
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.