APOD (apolipoprotein D) - Rat Genome Database
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Gene: APOD (apolipoprotein D) Homo sapiens
Analyze
Symbol: APOD
Name: apolipoprotein D
RGD ID: 737460
HGNC Page HGNC
Description: Exhibits cholesterol binding activity. Involved in several processes, including negative regulation of cell-matrix adhesion; negative regulation of macromolecule metabolic process; and negative regulation of protein import into nucleus. Localizes to extracellular space and perinuclear region of cytoplasm. Implicated in obesity and type 2 diabetes mellitus. Biomarker of Alzheimer's disease; gestational diabetes; and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: apo-D
RGD Orthologs
Mouse
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3195,568,705 - 195,584,033 (-)EnsemblGRCh38hg38GRCh38
GRCh383195,568,705 - 195,583,940 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373195,295,573 - 195,311,076 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh373195,295,576 - 195,310,811 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363196,776,865 - 196,792,278 (-)NCBINCBI36hg18NCBI36
Celera3193,705,274 - 193,720,781 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3192,666,066 - 192,681,572 (-)NCBIHuRef
CHM1_13195,258,489 - 195,273,995 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(-)-demecolcine  (EXP)
17beta-estradiol  (EXP)
2,2',4,4',5,5'-hexachlorobiphenyl  (ISO)
2,2',5,5'-tetrachlorobiphenyl  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,3,7,8-Tetrachlorodibenzofuran  (ISO)
2-acetamidofluorene  (ISO)
3,3',5,5'-tetrabromobisphenol A  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP)
3-methyladenine  (EXP)
3-methylcholanthrene  (ISO)
4,4'-sulfonyldiphenol  (ISO)
4-hydroxynon-2-enal  (ISO)
4-hydroxyphenyl retinamide  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
8-anilinonaphthalene-1-sulfonic acid  (EXP)
afimoxifene  (EXP)
aflatoxin B1  (EXP)
aflatoxin B2  (EXP)
alachlor  (ISO)
all-trans-4-oxoretinoic acid  (EXP)
all-trans-retinoic acid  (EXP)
all-trans-retinol  (EXP)
ammonium chloride  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP)
benzo[a]pyrene  (EXP,ISO)
benzo[e]pyrene  (EXP)
bexarotene  (ISO)
bisphenol A  (EXP,ISO)
bisphenol F  (ISO)
cadmium atom  (EXP)
cadmium dichloride  (EXP,ISO)
carbon nanotube  (ISO)
chloroquine  (EXP)
cisplatin  (EXP)
clozapine  (ISO)
copper atom  (EXP)
copper(0)  (EXP)
coumestrol  (EXP)
dexamethasone  (EXP)
dibenz[a,h]anthracene  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dioxygen  (EXP)
diuron  (ISO)
doxorubicin  (EXP,ISO)
fenvalerate  (ISO)
flavonoids  (ISO)
flurbiprofen  (ISO)
folic acid  (ISO)
formaldehyde  (EXP)
fulvestrant  (EXP)
furan  (ISO)
genistein  (EXP,ISO)
haloperidol  (ISO)
indometacin  (EXP)
isoprenaline  (ISO)
medroxyprogesterone acetate  (EXP)
methamphetamine  (ISO)
methapyrilene  (EXP)
methotrexate  (ISO)
methylseleninic acid  (EXP)
monosodium L-glutamate  (ISO)
naphthalene  (ISO)
nickel atom  (EXP)
ozone  (ISO)
paclitaxel  (EXP)
paraquat  (EXP,ISO)
PCB138  (ISO)
phencyclidine  (ISO)
progesterone  (EXP)
propanal  (EXP)
raloxifene  (EXP)
silicon dioxide  (EXP)
sirolimus  (EXP)
testosterone  (ISO)
trichostatin A  (EXP)
trimellitic anhydride  (ISO)
troglitazone  (ISO)
valproic acid  (EXP,ISO)
vincristine  (EXP)
vinyl carbamate  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

Additional References at PubMed
PMID:2083249   PMID:2244881   PMID:2439269   PMID:2891117   PMID:3104518   PMID:3453108   PMID:6774335   PMID:7613477   PMID:7918467   PMID:8549691   PMID:8692868   PMID:8889548  
PMID:9278274   PMID:10391209   PMID:11058760   PMID:11344130   PMID:11744388   PMID:12052480   PMID:12363390   PMID:12477932   PMID:12497622   PMID:12837283   PMID:12873803   PMID:14500696  
PMID:14551159   PMID:14596852   PMID:14718574   PMID:14760718   PMID:15192024   PMID:15316799   PMID:15489334   PMID:15862967   PMID:15916898   PMID:16169070   PMID:16335952   PMID:16344560  
PMID:16402085   PMID:16437381   PMID:16502470   PMID:16966838   PMID:17353931   PMID:17601350   PMID:17885669   PMID:18330697   PMID:18419796   PMID:18458334   PMID:18671953   PMID:18842892  
PMID:18977241   PMID:18979643   PMID:19056867   PMID:19176353   PMID:19330472   PMID:19519777   PMID:19723339   PMID:19878569   PMID:19913121   PMID:19944460   PMID:20023409   PMID:20430392  
PMID:20493910   PMID:20551380   PMID:20628086   PMID:20855565   PMID:21145461   PMID:21182205   PMID:21319273   PMID:21429623   PMID:21516116   PMID:21526344   PMID:21705670   PMID:21873635  
PMID:22479522   PMID:23296401   PMID:23376485   PMID:23533145   PMID:23602568   PMID:23690001   PMID:23715769   PMID:23777559   PMID:23895740   PMID:24167586   PMID:24623722   PMID:25261976  
PMID:25416956   PMID:25513803   PMID:25609649   PMID:25910212   PMID:25918162   PMID:25953740   PMID:26083030   PMID:26186194   PMID:26826316   PMID:26829325   PMID:27068509   PMID:27197790  
PMID:27271124   PMID:27705803   PMID:27804940   PMID:28301514   PMID:28514442   PMID:28675297   PMID:28977666   PMID:29117568   PMID:29222871   PMID:29509190   PMID:29863498   PMID:29869155  
PMID:30097533   PMID:30353968   PMID:30630053   PMID:31280863   PMID:31436131   PMID:31515488   PMID:31779197   PMID:32203420   PMID:32296183   PMID:32554047  


Genomics

Candidate Gene Status
APOD is a candidate Gene for QTL BW262_H
Comparative Map Data
APOD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl3195,568,705 - 195,584,033 (-)EnsemblGRCh38hg38GRCh38
GRCh383195,568,705 - 195,583,940 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373195,295,573 - 195,311,076 (-)NCBIGRCh37GRCh37hg19GRCh37
GRCh373195,295,576 - 195,310,811 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363196,776,865 - 196,792,278 (-)NCBINCBI36hg18NCBI36
Celera3193,705,274 - 193,720,781 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3192,666,066 - 192,681,572 (-)NCBIHuRef
CHM1_13195,258,489 - 195,273,995 (-)NCBICHM1_1
Apod
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391631,115,010 - 31,133,626 (-)NCBIGRCm39mm39
GRCm381631,296,192 - 31,314,808 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1631,296,192 - 31,314,808 (-)EnsemblGRCm38mm10GRCm38
MGSCv371631,296,278 - 31,314,682 (-)NCBIGRCm37mm9NCBIm37
MGSCv361631,215,939 - 31,234,343 (-)NCBImm8
Celera1631,811,354 - 31,812,738 (-)NCBICelera
Cytogenetic Map16B2NCBI
cM Map1621.41NCBI
Apod
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21169,431,261 - 69,452,306 (+)NCBI
Rnor_6.0 Ensembl1172,705,129 - 72,726,301 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01172,705,204 - 72,726,263 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01175,781,496 - 75,804,020 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1168,851,395 - 68,872,467 (+)NCBICelera
Cytogenetic Map11q22NCBI
Apod
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542013,553,058 - 13,573,690 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495542013,553,254 - 13,570,357 (+)NCBIChiLan1.0ChiLan1.0
APOD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.13203,152,476 - 203,167,888 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl3203,152,476 - 203,168,060 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v03192,852,887 - 192,868,233 (-)NCBIMhudiblu_PPA_v0panPan3
APOD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl3330,488,135 - 30,509,289 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.13330,490,149 - 30,504,804 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Apod
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936833260,798 - 277,060 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
APOD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl13132,514,949 - 132,562,599 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.113132,514,546 - 132,562,594 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.213142,076,180 - 142,096,088 (+)NCBISscrofa10.2Sscrofa10.2susScr3
APOD
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11589,612,210 - 89,624,038 (-)NCBI
ChlSab1.1 Ensembl1589,612,040 - 89,624,012 (-)Ensembl
Apod
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462473062,535,005 - 62,552,405 (+)NCBI

Position Markers
D3S1305  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373195,310,991 - 195,311,194UniSTSGRCh37
GRCh373195,311,005 - 195,311,194UniSTSGRCh37
Build 363196,792,294 - 196,792,483RGDNCBI36
Celera3193,720,710 - 193,720,899RGD
Celera3193,720,696 - 193,720,899UniSTS
HuRef3192,681,501 - 192,681,690UniSTS
HuRef3192,681,487 - 192,681,690UniSTS
Marshfield Genetic Map3222.83RGD
Genethon Genetic Map3225.1UniSTS
TNG Radiation Hybrid Map3108349.0UniSTS
deCODE Assembly Map3217.6UniSTS
Stanford-G3 RH Map38607.0UniSTS
NCBI RH Map32087.5UniSTS
GeneMap99-G3 RH Map39077.0UniSTS
GDB:181196  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373195,295,624 - 195,295,804UniSTSGRCh37
Build 363196,776,913 - 196,777,093RGDNCBI36
Celera3193,705,325 - 193,705,508RGD
Cytogenetic Map3q26.2-qterUniSTS
HuRef3192,666,117 - 192,666,301UniSTS
WI-18936  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373195,295,629 - 195,295,903UniSTSGRCh37
Build 363196,776,918 - 196,777,192RGDNCBI36
Celera3193,705,330 - 193,705,607RGD
Cytogenetic Map3q26.2-qterUniSTS
HuRef3192,666,122 - 192,666,400UniSTS
GeneMap99-GB4 RH Map3726.38UniSTS
Whitehead-RH Map3879.6UniSTS
STS-W81076  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373195,295,589 - 195,295,813UniSTSGRCh37
Build 363196,776,878 - 196,777,102RGDNCBI36
Celera3193,705,290 - 193,705,517RGD
Cytogenetic Map3q26.2-qterUniSTS
HuRef3192,666,082 - 192,666,310UniSTS
GeneMap99-GB4 RH Map3737.22UniSTS
STS-J02611  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373195,295,748 - 195,295,963UniSTSGRCh37
GRCh373195,295,601 - 195,295,777UniSTSGRCh37
Build 363196,776,890 - 196,777,066RGDNCBI36
Celera3193,705,452 - 193,705,667UniSTS
Celera3193,705,302 - 193,705,481RGD
Cytogenetic Map3q26.2-qterUniSTS
HuRef3192,666,094 - 192,666,274UniSTS
HuRef3192,666,245 - 192,666,460UniSTS
TNG Radiation Hybrid Map3108338.0UniSTS
GeneMap99-GB4 RH Map3726.38UniSTS
RH69430  
Human AssemblyChrPosition (strand)SourceJBrowse
GRCh373195,295,749 - 195,295,894UniSTSGRCh37
Build 363196,777,038 - 196,777,183RGDNCBI36
Celera3193,705,453 - 193,705,598RGD
Cytogenetic Map3q26.2-qterUniSTS
HuRef3192,666,246 - 192,666,391UniSTS
GeneMap99-GB4 RH Map3726.48UniSTS
STS-J02611  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3q26.2-qterUniSTS
TNG Radiation Hybrid Map3108338.0UniSTS
GeneMap99-GB4 RH Map3726.48UniSTS
D3S1305  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3q26.2-qterUniSTS
Marshfield Genetic Map3222.83UniSTS
Genethon Genetic Map3225.1UniSTS
deCODE Assembly Map3217.6UniSTS
D3S1305  
Human AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map3q26.2-qterUniSTS
TNG Radiation Hybrid Map3108349.0UniSTS
Stanford-G3 RH Map38607.0UniSTS
NCBI RH Map32087.5UniSTS
GeneMap99-G3 RH Map39077.0UniSTS

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1024
Count of miRNA genes:506
Interacting mature miRNAs:551
Transcripts:ENST00000343267, ENST00000421243, ENST00000453131, ENST00000458447, ENST00000463719
Prediction methods:Microtar, Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system sensory system visual system adipose tissue appendage entire extraembryonic component pharyngeal arch
High 243 464 391 102 4 2241 357 753 2 133 405 104 1 947 1396
Medium 2033 1808 842 84 401 24 1900 1783 2892 186 1126 946 62 257 1390 4 2
Low 90 647 381 338 1023 339 26 22 19 184 112 111 4 2 2
Below cutoff 55 66 90 84 346 84 108 27 41 19 49 93 4

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001647 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AB839003 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AC069213 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH002605 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK294523 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK312090 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC007402 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BQ008672 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019860 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BT019861 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU195270 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BU727194 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH471052 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR456838 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CR541773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DA892855 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  J02611 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  S80440 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENST00000343267   ⟹   ENSP00000345179
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3195,568,705 - 195,583,940 (-)Ensembl
RefSeq Acc Id: ENST00000421243   ⟹   ENSP00000415235
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3195,568,908 - 195,583,940 (-)Ensembl
RefSeq Acc Id: ENST00000453131   ⟹   ENSP00000393076
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3195,569,022 - 195,583,940 (-)Ensembl
RefSeq Acc Id: ENST00000458447   ⟹   ENSP00000391597
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3195,568,753 - 195,583,954 (-)Ensembl
RefSeq Acc Id: ENST00000463719
RefSeq Status:
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p13 Ensembl3195,570,591 - 195,584,033 (-)Ensembl
RefSeq Acc Id: NM_001647   ⟹   NP_001638
RefSeq Status: REVIEWED
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh383195,568,705 - 195,583,940 (-)NCBI
GRCh373195,295,573 - 195,311,076 (-)ENTREZGENE
Build 363196,776,865 - 196,792,278 (-)NCBI Archive
HuRef3192,666,066 - 192,681,572 (-)ENTREZGENE
CHM1_13195,258,489 - 195,273,995 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_001638   ⟸   NM_001647
- Peptide Label: precursor
- UniProtKB: P05090 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSP00000393076   ⟸   ENST00000453131
RefSeq Acc Id: ENSP00000391597   ⟸   ENST00000458447
RefSeq Acc Id: ENSP00000415235   ⟸   ENST00000421243
RefSeq Acc Id: ENSP00000345179   ⟸   ENST00000343267
Protein Domains
Lipocln_cytosolic_FA-bd_dom

Promoters
RGD ID:6866664
Promoter ID:EPDNEW_H6496
Type:initiation region
Name:APOD_1
Description:apolipoprotein D
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Human AssemblyChrPosition (strand)Source
GRCh383195,583,940 - 195,584,000EPDNEW
RGD ID:6851370
Promoter ID:EP73483
Type:initiation region
Name:HS_APOD
Description:Apolipoprotein D.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:NEDO full length human cDNA sequencing project.; Oligo-capping
Position:
Human AssemblyChrPosition (strand)Source
Build 363196,792,100 - 196,792,160EPD

Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 3q27.2-29(chr3:185485849-198110178)x1 copy number loss See cases [RCV000051608] Chr3:185485849..198110178 [GRCh38]
Chr3:185203637..197837049 [GRCh37]
Chr3:186686331..199321446 [NCBI36]
Chr3:3q27.2-29
pathogenic
GRCh38/hg38 3q24-29(chr3:147521892-198096565)x3 copy number gain See cases [RCV000051725] Chr3:147521892..198096565 [GRCh38]
Chr3:147239679..197823436 [GRCh37]
Chr3:148722369..199307833 [NCBI36]
Chr3:3q24-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:157293378-198134727)x3 copy number gain See cases [RCV000051726] Chr3:157293378..198134727 [GRCh38]
Chr3:157011167..197861598 [GRCh37]
Chr3:158493861..199345995 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q26.32-29(chr3:178411707-198110319)x3 copy number gain See cases [RCV000051736] Chr3:178411707..198110319 [GRCh38]
Chr3:178129495..197837190 [GRCh37]
Chr3:179612189..199321587 [NCBI36]
Chr3:3q26.32-29
pathogenic
GRCh38/hg38 3q27.2-29(chr3:185920880-198110319)x3 copy number gain See cases [RCV000051738] Chr3:185920880..198110319 [GRCh38]
Chr3:185638668..197837190 [GRCh37]
Chr3:187121362..199321587 [NCBI36]
Chr3:3q27.2-29
pathogenic
GRCh38/hg38 3q28-29(chr3:189265371-198110178)x3 copy number gain See cases [RCV000051739] Chr3:189265371..198110178 [GRCh38]
Chr3:188983160..197837049 [GRCh37]
Chr3:190465854..199321446 [NCBI36]
Chr3:3q28-29
pathogenic
GRCh38/hg38 3q28-29(chr3:190667663-198110178)x3 copy number gain See cases [RCV000051740] Chr3:190667663..198110178 [GRCh38]
Chr3:190385452..197837049 [GRCh37]
Chr3:191868146..199321446 [NCBI36]
Chr3:3q28-29
pathogenic
GRCh38/hg38 3q29(chr3:193917490-198110319)x3 copy number gain See cases [RCV000051741] Chr3:193917490..198110319 [GRCh38]
Chr3:193635279..197837190 [GRCh37]
Chr3:195117973..199321587 [NCBI36]
Chr3:3q29
pathogenic
GRCh38/hg38 3q29(chr3:194424496-198168758)x3 copy number gain See cases [RCV000051742] Chr3:194424496..198168758 [GRCh38]
Chr3:194145225..197895629 [GRCh37]
Chr3:195626514..199380026 [NCBI36]
Chr3:3q29
pathogenic
GRCh38/hg38 3q22.3-29(chr3:137126982-198110178)x3 copy number gain Developmental Delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|Developmental delay and additional significant developmental and morphological phenotypes referred for genetic testing [RCV000051723]|See cases [RCV000051723] Chr3:137126982..198110178 [GRCh38]
Chr3:136845824..197837049 [GRCh37]
Chr3:138328514..199321446 [NCBI36]
Chr3:3q22.3-29
pathogenic
NM_001647.3(APOD):c.334+239G>C single nucleotide variant Lung cancer [RCV000093443] Chr3:195571038 [GRCh38]
Chr3:195297909 [GRCh37]
Chr3:3q29
uncertain significance
NM_001647.3(APOD):c.124-2165C>G single nucleotide variant Lung cancer [RCV000093444] Chr3:195576136 [GRCh38]
Chr3:195303007 [GRCh37]
Chr3:3q29
uncertain significance
NM_001647.3(APOD):c.-34-1226G>T single nucleotide variant Lung cancer [RCV000093445] Chr3:195580721 [GRCh38]
Chr3:195307592 [GRCh37]
Chr3:3q29
uncertain significance
GRCh38/hg38 3q13.11-29(chr3:103426882-198110178)x3 copy number gain See cases [RCV000134948] Chr3:103426882..198110178 [GRCh38]
Chr3:103145726..197837049 [GRCh37]
Chr3:104628416..199321446 [NCBI36]
Chr3:3q13.11-29
pathogenic
GRCh38/hg38 3q29(chr3:194338534-197693741)x1 copy number loss See cases [RCV000136517] Chr3:194338534..197693741 [GRCh38]
Chr3:194059263..197420612 [GRCh37]
Chr3:195540958..198905009 [NCBI36]
Chr3:3q29
pathogenic|uncertain significance
GRCh38/hg38 3q29(chr3:195147600-195711857)x3 copy number gain See cases [RCV000136583] Chr3:195147600..195711857 [GRCh38]
Chr3:194868329..195438728 [GRCh37]
Chr3:196349618..196924399 [NCBI36]
Chr3:3q29
uncertain significance
GRCh38/hg38 3q29(chr3:195537179-195732718)x3 copy number gain See cases [RCV000135914] Chr3:195537179..195732718 [GRCh38]
Chr3:195263979..195459589 [GRCh37]
Chr3:196745268..196945260 [NCBI36]
Chr3:3q29
benign
GRCh38/hg38 3q26.2-29(chr3:168167568-198110178)x3 copy number gain See cases [RCV000137106] Chr3:168167568..198110178 [GRCh38]
Chr3:167885356..197837049 [GRCh37]
Chr3:169368050..199321446 [NCBI36]
Chr3:3q26.2-29
pathogenic
GRCh38/hg38 3q29(chr3:195537187-195736631)x3 copy number gain See cases [RCV000136843] Chr3:195537187..195736631 [GRCh38]
Chr3:195263987..195463502 [GRCh37]
Chr3:196745276..196949173 [NCBI36]
Chr3:3q29
benign
GRCh38/hg38 3q26.32-29(chr3:176439911-198118383)x3 copy number gain See cases [RCV000138009] Chr3:176439911..198118383 [GRCh38]
Chr3:176157699..197845254 [GRCh37]
Chr3:177640393..199329651 [NCBI36]
Chr3:3q26.32-29
pathogenic|likely benign
GRCh38/hg38 3q29(chr3:192752937-198118383)x3 copy number gain See cases [RCV000137827] Chr3:192752937..198118383 [GRCh38]
Chr3:192470726..197845254 [GRCh37]
Chr3:193953420..199329651 [NCBI36]
Chr3:3q29
pathogenic
GRCh38/hg38 3q26.32-29(chr3:176168525-198118383)x3 copy number gain See cases [RCV000138662] Chr3:176168525..198118383 [GRCh38]
Chr3:175886313..197845254 [GRCh37]
Chr3:177369007..199329651 [NCBI36]
Chr3:3q26.32-29
pathogenic
GRCh38/hg38 3q29(chr3:194296197-198110198)x3 copy number gain See cases [RCV000138492] Chr3:194296197..198110198 [GRCh38]
Chr3:194013986..197837069 [GRCh37]
Chr3:195496680..199321466 [NCBI36]
Chr3:3q29
pathogenic
GRCh38/hg38 3q29(chr3:195537024-195730806)x3 copy number gain See cases [RCV000138633] Chr3:195537024..195730806 [GRCh38]
Chr3:195263824..195457677 [GRCh37]
Chr3:196745113..196943348 [NCBI36]
Chr3:3q29
likely benign
GRCh38/hg38 3q29(chr3:195537024-195730806)x1 copy number loss See cases [RCV000138634] Chr3:195537024..195730806 [GRCh38]
Chr3:195263824..195457677 [GRCh37]
Chr3:196745113..196943348 [NCBI36]
Chr3:3q29
likely benign
GRCh38/hg38 3q25.1-29(chr3:152100512-198118383)x3 copy number gain See cases [RCV000139435] Chr3:152100512..198118383 [GRCh38]
Chr3:151818301..197845254 [GRCh37]
Chr3:153300991..199329651 [NCBI36]
Chr3:3q25.1-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:156321878-198113452)x3 copy number gain See cases [RCV000140849] Chr3:156321878..198113452 [GRCh38]
Chr3:156039667..197840323 [GRCh37]
Chr3:157522361..199324720 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q25.31-29(chr3:156118441-198125115)x3 copy number gain See cases [RCV000142310] Chr3:156118441..198125115 [GRCh38]
Chr3:155836230..197851986 [GRCh37]
Chr3:157318924..199336383 [NCBI36]
Chr3:3q25.31-29
pathogenic
GRCh38/hg38 3q26.1-29(chr3:166137209-198125115)x3 copy number gain See cases [RCV000143694] Chr3:166137209..198125115 [GRCh38]
Chr3:165854997..197851986 [GRCh37]
Chr3:167337691..199336383 [NCBI36]
Chr3:3q26.1-29
pathogenic
GRCh38/hg38 3q29(chr3:193704605-198125115)x3 copy number gain See cases [RCV000143501] Chr3:193704605..198125115 [GRCh38]
Chr3:193422394..197851986 [GRCh37]
Chr3:194905088..199336383 [NCBI36]
Chr3:3q29
pathogenic
GRCh37/hg19 3q25.32-29(chr3:158980631-197766890)x3 copy number gain See cases [RCV000447464] Chr3:158980631..197766890 [GRCh37]
Chr3:3q25.32-29
pathogenic
GRCh37/hg19 3q26.33-29(chr3:181911498-197851986)x4 copy number gain See cases [RCV000446732] Chr3:181911498..197851986 [GRCh37]
Chr3:3q26.33-29
pathogenic
GRCh37/hg19 3q25.2-29(chr3:152356847-197851986)x3 copy number gain See cases [RCV000448608] Chr3:152356847..197851986 [GRCh37]
Chr3:3q25.2-29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986)x3 copy number gain See cases [RCV000511055] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61892-197851986) copy number gain See cases [RCV000512358] Chr3:61892..197851986 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3q26.33-29(chr3:182539234-197851986)x3 copy number gain not provided [RCV000682336] Chr3:182539234..197851986 [GRCh37]
Chr3:3q26.33-29
pathogenic
GRCh37/hg19 3q27.1-29(chr3:184003967-197851986)x3 copy number gain not provided [RCV000682339] Chr3:184003967..197851986 [GRCh37]
Chr3:3q27.1-29
pathogenic
GRCh37/hg19 3q28-29(chr3:187913567-197851986)x3 copy number gain not provided [RCV000682344] Chr3:187913567..197851986 [GRCh37]
Chr3:3q28-29
pathogenic
GRCh37/hg19 3q28-29(chr3:191593619-197851986)x3 copy number gain not provided [RCV000682346] Chr3:191593619..197851986 [GRCh37]
Chr3:3q28-29
pathogenic
GRCh37/hg19 3q27.3-29(chr3:186374365-197851986)x3 copy number gain not provided [RCV000682341] Chr3:186374365..197851986 [GRCh37]
Chr3:3q27.3-29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:61495-197838262)x3 copy number gain not provided [RCV000742138] Chr3:61495..197838262 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3p26.3-q29(chr3:60174-197948027)x3 copy number gain not provided [RCV000742133] Chr3:60174..197948027 [GRCh37]
Chr3:3p26.3-q29
pathogenic
GRCh37/hg19 3q26.31-29(chr3:173281266-197838262)x3 copy number gain not provided [RCV000742968] Chr3:173281266..197838262 [GRCh37]
Chr3:3q26.31-29
pathogenic
GRCh37/hg19 3q27.3-29(chr3:186374671-197838262)x3 copy number gain not provided [RCV000743037] Chr3:186374671..197838262 [GRCh37]
Chr3:3q27.3-29
pathogenic
GRCh37/hg19 3q28-29(chr3:189101446-197838262)x1 copy number loss not provided [RCV000743049] Chr3:189101446..197838262 [GRCh37]
Chr3:3q28-29
pathogenic
NM_001647.4(APOD):c.44T>C (p.Phe15Ser) single nucleotide variant not provided [RCV000948671] Chr3:195579418 [GRCh38]
Chr3:195306289 [GRCh37]
Chr3:3q29
benign
NM_001647.4(APOD):c.165C>A (p.Thr55=) single nucleotide variant not provided [RCV000925461] Chr3:195573930 [GRCh38]
Chr3:195300801 [GRCh37]
Chr3:3q29
likely benign
GRCh37/hg19 3q29(chr3:195279196-196022437)x3 copy number gain not provided [RCV000846857] Chr3:195279196..196022437 [GRCh37]
Chr3:3q29
uncertain significance
GRCh37/hg19 3q28-29(chr3:188386566-197838262)x3 copy number gain See cases [RCV000790566] Chr3:188386566..197838262 [GRCh37]
Chr3:3q28-29
pathogenic
GRCh37/hg19 3q29(chr3:195068028-197851986)x3 copy number gain not provided [RCV001259831] Chr3:195068028..197851986 [GRCh37]
Chr3:3q29
pathogenic
GRCh37/hg19 3q29(chr3:194498718-196196789)x1 copy number loss not provided [RCV001270643] Chr3:194498718..196196789 [GRCh37]
Chr3:3q29
uncertain significance

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:612 AgrOrtholog
COSMIC APOD COSMIC
Ensembl Genes ENSG00000189058 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSP00000345179 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSP00000391597 UniProtKB/TrEMBL
  ENSP00000393076 UniProtKB/TrEMBL
  ENSP00000415235 UniProtKB/TrEMBL
Ensembl Transcript ENST00000343267 ENTREZGENE, UniProtKB/Swiss-Prot
  ENST00000421243 UniProtKB/TrEMBL
  ENST00000453131 UniProtKB/TrEMBL
  ENST00000458447 UniProtKB/TrEMBL
Gene3D-CATH 2.40.128.20 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
GTEx ENSG00000189058 GTEx
HGNC ID HGNC:612 ENTREZGENE
Human Proteome Map APOD Human Proteome Map
InterPro ApoD_vertbrte UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ApolipopD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Calycin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocalin_ApoD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocalin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lipocln_cytosolic_FA-bd_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report hsa:347 UniProtKB/Swiss-Prot
NCBI Gene 347 ENTREZGENE
OMIM 107740 OMIM
Pfam Lipocalin_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PharmGKB PA24900 PharmGKB
PIRSF Lipocalin_ApoD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS APODVERTBRTE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  APOLIPOPROTD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE LIPOCALIN UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF50814 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt APOD_HUMAN UniProtKB/Swiss-Prot
  C9JF17_HUMAN UniProtKB/TrEMBL
  C9JX71_HUMAN UniProtKB/TrEMBL
  F8WBT9_HUMAN UniProtKB/TrEMBL
  P05090 ENTREZGENE
UniProt Secondary B2R579 UniProtKB/Swiss-Prot
  D3DNW6 UniProtKB/Swiss-Prot
  Q6IBG6 UniProtKB/Swiss-Prot