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Gene: ADRA2A (adrenoceptor alpha 2A) Homo sapiens
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Symbol: ADRA2A
Name: adrenoceptor alpha 2A
Description: Exhibits several functions, including catecholamine binding activity; enzyme binding activity; and protein dimerization activity. Involved in several processes, including adrenergic receptor signaling pathway; negative regulation of insulin secretion involved in cellular response to glucose stimulus; and positive regulation of cellular protein metabolic process. Localizes to the cytoplasm; integral component of plasma membrane; and receptor complex. Implicated in attention deficit hyperactivity disorder and type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADRA2; ADRA2R; ADRAR; adrenergic receptor, alpha 2a; adrenergic, alpha-2A-, receptor; alpha-2 adrenergic receptor subtype C10; alpha-2-adrenergic receptor, platelet type; alpha-2A adrenergic receptor; alpha-2A adrenoceptor; alpha-2A adrenoreceptor; alpha-2AAR subtype C10; ALPHA2AAR; ZNF32
Orthologs:
Mus musculus (house mouse) : Adra2a (adrenergic receptor, alpha 2a)  MGI  Alliance
Rattus norvegicus (Norway rat) : Adra2a (adrenoceptor alpha 2A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Adra2a (adrenoceptor alpha 2A)
Pan paniscus (bonobo/pygmy chimpanzee) : ADRA2A (adrenoceptor alpha 2A)
Canis lupus familiaris (dog) : ADRA2A (adrenoceptor alpha 2A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Adra2a (adrenoceptor alpha 2A)
Sus scrofa (pig) : ADRA2A (adrenoceptor alpha 2A)
Chlorocebus sabaeus (African green monkey) : ADRA2A (adrenoceptor alpha 2A)
Heterocephalus glaber (naked mole-rat) : Adra2a (adrenoceptor alpha 2A)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl10111,077,029 - 111,080,907 (+)Ensembl
GRCh3810111,077,029 - 111,080,907 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710112,836,790 - 112,840,665 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610112,826,911 - 112,830,560 (+)NCBINCBI36hg18NCBI36
Build 3410112,826,910 - 112,830,560NCBI
Celera10106,568,388 - 106,572,263 (+)NCBI
Cytogenetic Map10q25.2ENTREZGENE
HuRef10106,465,554 - 106,469,429 (+)NCBIHuRef
CHM1_110113,118,624 - 113,122,499 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on ADRA2A
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737381
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2020-01-14
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.