Cacng1 (calcium channel, voltage-dependent, gamma subunit 1) - Rat Genome Database

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Gene: Cacng1 (calcium channel, voltage-dependent, gamma subunit 1) Mus musculus
Analyze
Symbol: Cacng1
Name: calcium channel, voltage-dependent, gamma subunit 1
RGD ID: 737287
MGI Page MGI
Description: Enables voltage-gated calcium channel activity. Acts upstream of or within calcium ion transmembrane transport; establishment of localization in cell; and sarcoplasmic reticulum calcium ion transport. Predicted to be located in plasma membrane. Predicted to be part of L-type voltage-gated calcium channel complex. Is expressed in brain; heart; retina; and spinal cord. Human ortholog(s) of this gene implicated in malignant hyperthermia. Orthologous to human CACNG1 (calcium voltage-gated channel auxiliary subunit gamma 1).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: dihydropyridine receptor gamma 1; dihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gamma; MGC117703; voltage-dependent calcium channel gamma-1 subunit
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911107,594,044 - 107,607,302 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11107,594,044 - 107,607,348 (-)EnsemblGRCm39 Ensembl
GRCm3811107,703,218 - 107,716,476 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11107,703,218 - 107,716,522 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711107,564,532 - 107,577,790 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611107,519,308 - 107,532,566 (-)NCBIMGSCv36mm8
Celera11119,438,411 - 119,451,651 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1170.29NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

References - curated
# Reference Title Reference Citation
1. Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility. Iles DE, etal., Hum Mol Genet 1993 Jul;2(7):863-8.
2. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
3. MGDs mouse GO annotations MGD data from the GO Consortium
4. MGD IEA MGD IEA
5. Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. Mouse MP Annotation Import Pipeline RGD automated import pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
Additional References at PubMed
PMID:9504716   PMID:10349636   PMID:10799530   PMID:11042159   PMID:11076861   PMID:11217851   PMID:11389198   PMID:11495636   PMID:12477932   PMID:15504904   PMID:16141072   PMID:16141073  
PMID:16602821   PMID:16985003   PMID:17906876   PMID:17978188   PMID:18192372   PMID:21267068   PMID:21677750   PMID:21873635   PMID:22982493   PMID:29866044   PMID:33911096  


Genomics

Comparative Map Data
Cacng1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911107,594,044 - 107,607,302 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl11107,594,044 - 107,607,348 (-)EnsemblGRCm39 Ensembl
GRCm3811107,703,218 - 107,716,476 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11107,703,218 - 107,716,522 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711107,564,532 - 107,577,790 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv3611107,519,308 - 107,532,566 (-)NCBIMGSCv36mm8
Celera11119,438,411 - 119,451,651 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1170.29NCBI
CACNG1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381767,044,554 - 67,056,797 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1767,044,554 - 67,056,797 (+)EnsemblGRCh38hg38GRCh38
GRCh371765,040,670 - 65,052,913 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361762,471,168 - 62,483,375 (+)NCBINCBI36Build 36hg18NCBI36
Build 341762,471,167 - 62,483,371NCBI
Celera1761,613,382 - 61,625,583 (+)NCBICelera
Cytogenetic Map17q24.2NCBI
HuRef1760,429,261 - 60,441,513 (+)NCBIHuRef
CHM1_11765,104,606 - 65,116,856 (+)NCBICHM1_1
T2T-CHM13v2.01767,920,364 - 67,932,598 (+)NCBIT2T-CHM13v2.0
Cacng1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81093,152,558 - 93,165,246 (-)NCBIGRCr8
mRatBN7.21092,652,924 - 92,665,612 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1092,652,614 - 92,665,783 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1097,711,022 - 97,723,710 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01097,174,042 - 97,186,732 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01092,575,656 - 92,588,362 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01095,921,479 - 95,934,170 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1095,921,174 - 95,934,345 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01095,655,624 - 95,668,315 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41097,105,707 - 97,118,400 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11097,120,076 - 97,132,770 (-)NCBI
Celera1091,318,721 - 91,331,399 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Cacng1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554786,294,974 - 6,305,669 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554786,295,046 - 6,305,625 (+)NCBIChiLan1.0ChiLan1.0
CACNG1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v21983,071,599 - 83,090,853 (+)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11787,891,441 - 87,914,656 (+)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01760,978,895 - 60,993,621 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11766,187,565 - 66,199,795 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1766,187,565 - 66,199,789 (+)Ensemblpanpan1.1panPan2
CACNG1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1913,425,898 - 13,438,275 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl913,426,105 - 13,438,614 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha914,320,527 - 14,332,878 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0915,088,975 - 15,101,463 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl915,089,182 - 15,101,509 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1914,036,391 - 14,048,856 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0913,485,243 - 13,497,697 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0913,486,979 - 13,499,379 (+)NCBIUU_Cfam_GSD_1.0
Cacng1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560213,154,750 - 13,165,862 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365416,028,669 - 6,040,034 (-)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365416,028,775 - 6,039,882 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNG1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1213,463,058 - 13,481,645 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11213,462,589 - 13,481,651 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21213,833,206 - 13,844,295 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CACNG1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11654,383,328 - 54,397,331 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl1654,383,204 - 54,396,610 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_02366607725,422,067 - 25,435,899 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Cacng1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248701,333,843 - 1,344,483 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248701,333,907 - 1,344,386 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Cacng1
371 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:273
Count of miRNA genes:214
Interacting mature miRNAs:240
Transcripts:ENSMUST00000021065
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156864027114157957Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162590826109390826Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177063779111063918Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177437183111437322Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177437183111437322Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177770978111771099Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179156009107616472Mouse
14746970Manh71_mmandible shape 71 (mouse)1179416257113416257Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181574481115574636Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181574481115574636Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181810267115810267Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182377698116377820Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185844911119844911Mouse
15039374Adip29_madiposity 29 (mouse)1186608320120608320Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186608320120608320Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186608320120608320Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187490826121873369Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187502600121502698Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189869251121973369Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191604608121973369Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191604608121973369Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1192939373112544554Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193229183121973369Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194063779118022724Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194190826118890826Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94437183118022724Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195403965121973369Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195403965121973369Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196137674121973369Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196176465108806384Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196810136121973369Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1196897693110603991Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198352609121973369Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198500469121973369Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199254187121973369Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100058103121973369Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100254186120887165Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101022590121973369Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101504820114472363Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101504820114472363Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101504820114472363Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101504820114472363Mouse
1300957Pbd1_mpeak bone density 1 (mouse)Not determined11102344123112384123Mouse
4141612Cia40_mcollagen induced arthritis 40 (mouse)Not determined11103273992115021444Mouse

Markers in Region
25.MMHAP50FRA10.seq  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811107,703,326 - 107,703,476UniSTSGRCm38
MGSCv3711107,564,640 - 107,564,790UniSTSGRCm37
Celera11119,438,519 - 119,438,669UniSTS
Cytogenetic Map11E1UniSTS
Whitehead_YAC11 UniSTS


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000021065   ⟹   ENSMUSP00000021065
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl11107,594,044 - 107,607,348 (-)Ensembl
GRCm38.p6 Ensembl11107,703,218 - 107,716,522 (-)Ensembl
RefSeq Acc Id: NM_007582   ⟹   NP_031608
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911107,594,044 - 107,607,302 (-)NCBI
GRCm3811107,703,218 - 107,716,476 (-)ENTREZGENE
MGSCv3711107,564,532 - 107,577,790 (-)RGD
Celera11119,438,411 - 119,451,651 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Protein Sequences
Protein RefSeqs NP_031608 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AAH99482 (Get FASTA)   NCBI Sequence Viewer  
  BAE21242 (Get FASTA)   NCBI Sequence Viewer  
  CAA06966 (Get FASTA)   NCBI Sequence Viewer  
  EDL34335 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSMUSP00000021065
  ENSMUSP00000021065.6
GenBank Protein O70578 (Get FASTA)   NCBI Sequence Viewer  
Reference Protein Sequences
RefSeq Acc Id: NP_031608   ⟸   NM_007582
- UniProtKB: O70578 (UniProtKB/Swiss-Prot),   Q4KL26 (UniProtKB/TrEMBL),   Q3V1A9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000021065   ⟸   ENSMUST00000021065

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-O70578-F1-model_v2 AlphaFold O70578 1-223 view protein structure

Promoters
RGD ID:8677136
Promoter ID:EPDNEW_M16599
Type:initiation region
Name:Cacng1_1
Description:Mus musculus calcium channel, voltage-dependent, gamma subunit1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811107,716,469 - 107,716,529EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1206582 AgrOrtholog
Ensembl Genes ENSMUSG00000020722 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000021065 ENTREZGENE
  ENSMUST00000021065.6 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.140.150 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro PMP22/EMP/MP20/Claudin UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_g1su UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCC_gsu UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:12299 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:1206582 ENTREZGENE
NCBI Gene 12299 ENTREZGENE
PANTHER VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT-RELATED UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam Claudin_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Cacng1 PhenoGen
PRINTS VDCCGAMMA UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  VDCCGAMMA1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt CCG1_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q3V1A9 ENTREZGENE, UniProtKB/TrEMBL
  Q4KL26 ENTREZGENE, UniProtKB/TrEMBL