Ptprv (protein tyrosine phosphatase, receptor type, V) - Rat Genome Database

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Gene: Ptprv (protein tyrosine phosphatase, receptor type, V) Mus musculus
Analyze
Symbol: Ptprv
Name: protein tyrosine phosphatase, receptor type, V
RGD ID: 737251
MGI Page MGI
Description: Predicted to enable protein tyrosine phosphatase activity. Predicted to be involved in protein dephosphorylation. Is expressed in several structures, including early conceptus; gonad; hemolymphoid system gland; limb; and skeleton. Orthologous to human PTPRVP (protein tyrosine phosphatase receptor type V, pseudogene).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: E; embryonic stem cell phosphatase; embryonic stem cell protein-tyrosine phosphatase; ES cell phosphatase; Esp; mOST; mOST-PTP; O; OST; OST-PTP; R-PTP-V; receptor-type tyrosine-protein phosphatase V; tyrosine phosphatase
RGD Orthologs
Human
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,036,236 - 135,060,313 (-)NCBIGRCm39mm39
GRCm39 Ensembl1135,036,235 - 135,060,332 (-)Ensembl
GRCm381135,108,498 - 135,132,575 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,108,497 - 135,132,594 (-)EnsemblGRCm38mm10GRCm38
MGSCv371137,005,075 - 137,029,152 (-)NCBIGRCm37mm9NCBIm37
MGSCv361136,924,923 - 136,945,687 (-)NCBImm8
Celera1137,735,674 - 137,759,530 (-)NCBICelera
Cytogenetic Map1E4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal glucose homeostasis  (IAGP)
abnormal male germ cell apoptosis  (IAGP)
abnormal male germ cell morphology  (IAGP)
abnormal mitochondrial morphology  (IAGP)
abnormal pancreatic islet morphology  (IAGP)
decreased circulating free fatty acids level  (IAGP)
decreased circulating glucose level  (IAGP)
decreased circulating potassium level  (IEA)
decreased circulating triglyceride level  (IAGP)
decreased gonadal fat pad weight  (IAGP)
decreased mean corpuscular volume  (IEA)
decreased prepulse inhibition  (IEA)
decreased sensitivity to xenobiotic induced morbidity/mortality  (IAGP)
decreased susceptibility to diet-induced obesity  (IAGP)
enlarged testis  (IAGP)
hypoglycemia  (IAGP)
improved glucose tolerance  (IAGP)
increased adipocyte glucose uptake  (IAGP)
increased circulating adiponectin level  (IAGP)
increased circulating insulin level  (IAGP)
increased circulating testosterone level  (IAGP)
increased energy expenditure  (IAGP)
increased epididymis weight  (IAGP)
increased fat cell size  (IAGP)
increased insulin secretion  (IAGP)
increased insulin sensitivity  (IAGP)
increased Leydig cell number  (IAGP)
increased muscle cell glucose uptake  (IAGP)
increased pancreatic beta cell mass  (IAGP)
increased pancreatic beta cell proliferation  (IAGP)
increased pancreatic islet number  (IAGP)
increased seminal vesicle weight  (IAGP)
increased sperm number  (IAGP)
increased testis weight  (IAGP)
no abnormal phenotype detected  (IAGP)
pancreatic islet hyperplasia  (IAGP)
postnatal lethality, incomplete penetrance  (IAGP)
References

Additional References at PubMed
PMID:8843390   PMID:8951793   PMID:9546595   PMID:10349636   PMID:11042159   PMID:11076861   PMID:11080586   PMID:11217851   PMID:11423996   PMID:14610273   PMID:15042706   PMID:15660420  
PMID:15780994   PMID:16107883   PMID:16141072   PMID:16141073   PMID:17693256   PMID:18391535   PMID:19103808   PMID:19726872   PMID:20038793   PMID:20655470   PMID:21267068   PMID:21333348  
PMID:21873635   PMID:24569637   PMID:25920569   PMID:27626380  


Genomics

Comparative Map Data
Ptprv
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391135,036,236 - 135,060,313 (-)NCBIGRCm39mm39
GRCm39 Ensembl1135,036,235 - 135,060,332 (-)Ensembl
GRCm381135,108,498 - 135,132,575 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1135,108,497 - 135,132,594 (-)EnsemblGRCm38mm10GRCm38
MGSCv371137,005,075 - 137,029,152 (-)NCBIGRCm37mm9NCBIm37
MGSCv361136,924,923 - 136,945,687 (-)NCBImm8
Celera1137,735,674 - 137,759,530 (-)NCBICelera
Cytogenetic Map1E4NCBI
PTPRVP
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1202,168,051 - 202,189,455 (+)EnsemblGRCh38hg38GRCh38
GRCh381202,168,051 - 202,189,449 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371202,137,179 - 202,158,577 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361200,403,802 - 200,425,104 (+)NCBINCBI36hg18NCBI36
Celera1175,261,036 - 175,282,499 (+)NCBI
Cytogenetic Map1q32.1NCBI
HuRef1173,302,732 - 173,324,045 (+)NCBIHuRef
CHM1_11203,559,463 - 203,580,808 (+)NCBICHM1_1

Position Markers
Ptprv  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371137,005,224 - 137,005,560UniSTSGRCm37
MGSCv371137,015,261 - 137,016,401UniSTSGRCm37
Celera1137,735,821 - 137,736,157UniSTS
Celera1137,745,646 - 137,746,845UniSTS
cM Map1 UniSTS
Ptprv  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381135,118,684 - 135,119,824UniSTSGRCm38
MGSCv371137,015,261 - 137,016,401UniSTSGRCm37
Celera1137,745,646 - 137,746,845UniSTS
Ptprv  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381135,108,647 - 135,108,983UniSTSGRCm38
MGSCv371137,005,224 - 137,005,560UniSTSGRCm37
Celera1137,735,821 - 137,736,157UniSTS
cM Map1 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
13824984Twq5_mtestis weight QTL 5 (mouse)13000000185000000Mouse
1357753Kidq2_mkidney weight QTL 2 (mouse)Not determined134721057150318120Mouse
1357488Splq3_mspleen weight QTL 3 (mouse)Not determined134721057150318120Mouse
1558860W10q7_mweight 10 weeks QTL 7 (mouse)Not determined134721057150318120Mouse
1301722Cia9_mcollagen induced arthritis QTL 9 (mouse)Not determined145744740189571420Mouse
4142291Aec2_mautoimmune exocrinopathy 2 (mouse)Not determined52418578182423027Mouse
10412185Hcs9_mhepatocarcinogenesis susceptibility 9 (mouse)Not determined163815531189571420Mouse
1300841Ssial1_msusceptibility to sialadenitis 1 (mouse)Not determined163880843153681816Mouse
1300989Lrdg1_mlight induced retinal degeneration 1 (mouse)Not determined173716016147249632Mouse
4141914Gcsfis_mG-CSF induced splenomegaly (mouse)Not determined74477076148839837Mouse
27095928Pglq6_mpelvic girdle length QTL 6, 10 week (mouse)176000000148900000Mouse
26884448Sklq1_mskull length QTL 1, 5 week (mouse)176000000181500000Mouse
1301350Nidd4k_mNidd4 on KK-A (mouse)Not determined782314261147249632Mouse
1357439Popoa_mpremature ovulation and primary oocyte arrest (mouse)Not determined182665468135687641Mouse
27095913Scvln2_msacral vertebrae length 2, 5 week (mouse)194200000148900000Mouse
27095901Scvln8_msacral vertebrae length 2, 10 week (mouse)194200000172200000Mouse
27226779Tibl1_mtibia length 1, 5 week (mouse)195600000162200000Mouse
1301193Lxw3_mlupus BXSB x NZW 3 (mouse)Not determined1103040804137040937Mouse
10412162Nobq3_mNew Zealand obese QTL 3 (mouse)Not determined1104005680191493284Mouse
12790994Aaaq1_maortic arch angle QTL 1 (mouse)1109568206143568206Mouse
1301979Melm1_mmelanoma modifier 1 (mouse)Not determined1109710525143710742Mouse
1357600Obq17_mobesity QTL 17 (mouse)Not determined1110625442144625561Mouse
10401248Bglu12_mblood glucose level 12 (mouse)Not determined1110625442144625561Mouse
1301149Lrnx12_mlearning-contextual 12 (mouse)Not determined1112081092168358833Mouse
1302098Eila1_methanol induced locomotor activity 1 (mouse)Not determined1112081092175641372Mouse
1301249Sbw1_msplenomegaly-NZB x NZW 1 (mouse)Not determined1112203268146203348Mouse
10045640Jckm4_mjuvenile cystic kidney modifier 4 (mouse)Not determined1116363098150363199Mouse
27095915Scvln13_msacral vertebrae length 2, 16 week (mouse)1117600000180000000Mouse
1302161Exq2_mexploratory and excitability QTL 2 (mouse)Not determined1118171982152172078Mouse
27226714Metcl1_mmetatarsal-calcaneal length 1, 5 week (mouse)1121800000139800000Mouse
27226740Metcl13_mmetatarsal-calcaneal length 13, 16 week (mouse)1121800000153900000Mouse
27226743Metcl7_mmetatarsal-calcaneal length 7, 10 week (mouse)1121800000154000000Mouse
27226767Tibl10_mtibia length 10, 10 week (mouse)1121800000165000000Mouse
27226799Feml5_mfemur length 5, 5 week (mouse)1122100000165000000Mouse
12880408V125Dq3_mvitamin D active form serum level QTL 3 (mouse)1123000000157000000Mouse
1301488Tir3b_mtrypansomiasis infection response 3b (mouse)Not determined1128551097157361794Mouse
27095935Ulnl5_mulna length 5, 10 week (mouse)1128800000181500000Mouse
1301608Emo3_memotionality 3 (mouse)Not determined1129255120163255255Mouse
1302128Ity3_mimmunity to S. typhimurium 3 (mouse)Not determined11131228571165311895Mouse
14746980Manh50_mmandible shape 50 (mouse)1134255813168255813Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1835
Count of miRNA genes:610
Interacting mature miRNAs:763
Transcripts:ENSMUST00000086432, ENSMUST00000182012, ENSMUST00000182120, ENSMUST00000182387, ENSMUST00000182541, ENSMUST00000182570, ENSMUST00000182718, ENSMUST00000183089, ENSMUST00000183212, ENSMUST00000183317, ENSMUST00000183328
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000086432   ⟹   ENSMUSP00000159183
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,038,907 - 135,040,044 (-)Ensembl
GRCm38.p6 Ensembl1135,111,169 - 135,112,306 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182012
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,036,367 - 135,037,327 (-)Ensembl
GRCm38.p6 Ensembl1135,108,629 - 135,109,589 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182120
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,036,235 - 135,037,174 (-)Ensembl
GRCm38.p6 Ensembl1135,108,497 - 135,109,436 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182387
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,054,114 - 135,056,000 (-)Ensembl
GRCm38.p6 Ensembl1135,126,376 - 135,128,262 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182541
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,054,096 - 135,060,306 (-)Ensembl
GRCm38.p6 Ensembl1135,126,358 - 135,132,568 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182570
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,036,238 - 135,037,046 (-)Ensembl
GRCm38.p6 Ensembl1135,108,500 - 135,109,308 (-)Ensembl
RefSeq Acc Id: ENSMUST00000182718
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,038,013 - 135,039,284 (-)Ensembl
GRCm38.p6 Ensembl1135,110,275 - 135,111,546 (-)Ensembl
RefSeq Acc Id: ENSMUST00000183089
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,037,754 - 135,038,202 (-)Ensembl
GRCm38.p6 Ensembl1135,110,016 - 135,110,464 (-)Ensembl
RefSeq Acc Id: ENSMUST00000183212
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,057,319 - 135,060,281 (-)Ensembl
GRCm38.p6 Ensembl1135,129,581 - 135,132,543 (-)Ensembl
RefSeq Acc Id: ENSMUST00000183317   ⟹   ENSMUSP00000158886
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,036,236 - 135,060,332 (-)Ensembl
GRCm38.p6 Ensembl1135,108,498 - 135,132,594 (-)Ensembl
RefSeq Acc Id: ENSMUST00000183328
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1135,057,210 - 135,058,901 (-)Ensembl
GRCm38.p6 Ensembl1135,129,472 - 135,131,163 (-)Ensembl
RefSeq Acc Id: NR_153383
RefSeq Status: VALIDATED
Type: NON-CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391135,036,236 - 135,060,313 (-)NCBI
GRCm381135,108,498 - 135,132,575 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: ENSMUSP00000159183   ⟸   ENSMUST00000086432
RefSeq Acc Id: ENSMUSP00000158886   ⟸   ENSMUST00000183317
Promoters
RGD ID:6875040
Promoter ID:EPDNEW_M971
Type:single initiation site
Name:Ptprv_2
Description:Mus musculus protein tyrosine phosphatase, receptor type, V ,non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M972  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381135,129,209 - 135,129,269EPDNEW
RGD ID:15092210
Promoter ID:EPDNEWNC_M111
Type:single initiation site
Name:Ptprv_1
Description:protein tyrosine phosphatase, receptor type, V [Source:MGISymbol;Acc:MGI:108027]
SO ACC ID:SO:0000170
Source:EPDNEWNC (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381135,131,163 - 135,131,223EPDNEWNC
RGD ID:6875042
Promoter ID:EPDNEW_M972
Type:initiation region
Name:Ptprv_1
Description:Mus musculus protein tyrosine phosphatase, receptor type, V ,non-coding RNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Alternative Promoters:null; see alsoEPDNEW_M971  
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381135,132,576 - 135,132,636EPDNEW
RGD ID:15092206
Promoter ID:EPDNEWNC_M112
Type:multiple initiation site
Name:Ptprv_2
Description:protein tyrosine phosphatase, receptor type, V [Source:MGISymbol;Acc:MGI:108027]
SO ACC ID:SO:0000170
Source:EPDNEWNC (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381135,132,576 - 135,132,636EPDNEWNC
RGD ID:6818337
Promoter ID:MM_KWN:2180
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   ES_Cell
Transcripts:UC007CSR.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361137,025,856 - 137,027,007 (-)MPROMDB
RGD ID:6818335
Promoter ID:MM_KWN:2182
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Lung,   Spleen
Transcripts:NM_007955,   NM_007955_PTPRV,   NM_177081
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361137,029,199 - 137,029,699 (+)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:108027 AgrOrtholog
Ensembl Genes ENSMUSG00000066885
  ENSMUSG00000097993 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000159183 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000086432 UniProtKB/TrEMBL
  ENSMUST00000183317 ENTREZGENE
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.90.190.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro FN3_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  FN3_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot-tyrosine_phosphatase-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPase_domain UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPRJ_TM UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_AS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Tyr_Pase_cat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:108027 ENTREZGENE
NCBI Gene 13924 ENTREZGENE
Pfam fn3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTP_tm UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Y_phosphatase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ptprv PhenoGen
PRINTS PRTYPHPHTASE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  TYR_PHOSPHATASE_PTP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART FN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  PTPc_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49265 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52799 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A5F8MPY9_MOUSE UniProtKB/TrEMBL
  P70289 ENTREZGENE, UniProtKB/Swiss-Prot
  Q60704_MOUSE UniProtKB/TrEMBL
  Q64504_MOUSE UniProtKB/TrEMBL
  Q9ERK5_MOUSE UniProtKB/TrEMBL