Ddx1 (DEAD box helicase 1) - Rat Genome Database

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Gene: Ddx1 (DEAD box helicase 1) Mus musculus
Analyze
Symbol: Ddx1
Name: DEAD box helicase 1
RGD ID: 737233
MGI Page MGI
Description: Enables double-stranded RNA binding activity. Involved in positive regulation of I-kappaB kinase/NF-kappaB signaling and positive regulation of myeloid dendritic cell cytokine production. Acts upstream of or within response to exogenous dsRNA and response to virus. Located in cytoplasmic stress granule; cytosol; and mitochondrion. Is expressed in several structures, including 1st branchial arch; cardiovascular system; central nervous system; genitourinary system; and stomach. Orthologous to human DDX1 (DEAD-box helicase 1).
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: AA409185; ATP-dependent RNA helicase DDX1; DBP-RB; DEAD (Asp-Glu-Ala-Asp) box polypeptide 1; DEAD box protein 1; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391213,269,308 - 13,299,175 (-)NCBIGRCm39mm39
GRCm39 Ensembl1213,266,974 - 13,299,214 (-)Ensembl
GRCm381213,219,307 - 13,249,174 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1213,216,973 - 13,249,213 (-)EnsemblGRCm38mm10GRCm38
MGSCv371213,226,113 - 13,255,980 (-)NCBIGRCm37mm9NCBIm37
MGSCv361213,245,295 - 13,275,162 (-)NCBImm8
Celera1213,565,291 - 13,593,111 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
References

Additional References at PubMed
PMID:7689221   PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12477932   PMID:12520002   PMID:12533789   PMID:12904583   PMID:14610273  
PMID:15489334   PMID:15782199   PMID:16041369   PMID:16141072   PMID:16141073   PMID:18323671   PMID:18495661   PMID:18758164   PMID:18799693   PMID:18809582   PMID:19340935   PMID:19398953  
PMID:21703541   PMID:21873635   PMID:21933836   PMID:22586277   PMID:22902294   PMID:23892456   PMID:24090483   PMID:24194600   PMID:24457600   PMID:25176654   PMID:25299332   PMID:25909345  
PMID:26167872   PMID:26206133   PMID:26265008   PMID:26336360   PMID:26370502   PMID:26510153   PMID:28378742   PMID:28978771   PMID:29530978   PMID:29731414   PMID:30196744   PMID:30295850  
PMID:30457570   PMID:30550785   PMID:31330130   PMID:32325033   PMID:33503245   PMID:34388251   PMID:35012549  


Genomics

Comparative Map Data
Ddx1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391213,269,308 - 13,299,175 (-)NCBIGRCm39mm39
GRCm39 Ensembl1213,266,974 - 13,299,214 (-)Ensembl
GRCm381213,219,307 - 13,249,174 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1213,216,973 - 13,249,213 (-)EnsemblGRCm38mm10GRCm38
MGSCv371213,226,113 - 13,255,980 (-)NCBIGRCm37mm9NCBIm37
MGSCv361213,245,295 - 13,275,162 (-)NCBImm8
Celera1213,565,291 - 13,593,111 (-)NCBICelera
Cytogenetic Map12A1.1NCBI
DDX1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38215,591,868 - 15,631,101 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl215,591,178 - 15,634,346 (+)EnsemblGRCh38hg38GRCh38
GRCh37215,731,992 - 15,771,225 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36215,649,221 - 15,688,676 (+)NCBINCBI36hg18NCBI36
Build 34215,682,367 - 15,721,823NCBI
Celera215,649,490 - 15,688,945 (+)NCBI
Cytogenetic Map2p24.3NCBI
HuRef215,583,004 - 15,622,496 (+)NCBIHuRef
CHM1_1215,661,598 - 15,701,093 (+)NCBICHM1_1
Ddx1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.2635,996,469 - 36,027,340 (-)NCBImRatBN7.2
mRatBN7.2 Ensembl635,996,469 - 36,027,365 (-)Ensembl
Rnor_6.0638,422,892 - 38,453,762 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl638,422,888 - 38,453,797 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0647,188,697 - 47,219,567 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4636,794,602 - 36,825,473 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1636,812,356 - 36,818,005 (-)NCBI
Celera635,359,044 - 35,389,916 (-)NCBICelera
Cytogenetic Map6q15NCBI
Ddx1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554879,085,918 - 9,119,979 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554879,085,950 - 9,117,599 (+)NCBIChiLan1.0ChiLan1.0
DDX1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.12A15,716,044 - 15,753,482 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl2A15,716,044 - 15,753,623 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v02A15,582,499 - 15,619,751 (+)NCBIMhudiblu_PPA_v0panPan3
DDX1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11711,432,060 - 11,467,000 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1711,432,136 - 11,466,990 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1711,375,128 - 11,409,962 (+)NCBI
ROS_Cfam_1.01711,559,789 - 11,594,731 (+)NCBI
ROS_Cfam_1.0 Ensembl1711,559,798 - 11,594,727 (+)Ensembl
UMICH_Zoey_3.11711,419,496 - 11,454,379 (+)NCBI
UNSW_CanFamBas_1.01711,429,814 - 11,464,805 (+)NCBI
UU_Cfam_GSD_1.01711,454,120 - 11,488,966 (+)NCBI
Ddx1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440629255,920,933 - 55,954,651 (+)NCBI
SpeTri2.0NW_00493649314,884,532 - 14,918,621 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
DDX1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl3121,818,406 - 121,853,958 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.13121,818,400 - 121,856,667 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.23130,448,196 - 130,480,756 (+)NCBISscrofa10.2Sscrofa10.2susScr3
DDX1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11492,007,446 - 92,045,414 (-)NCBIChlSab1.1chlSab2
ChlSab1.1 Ensembl1492,007,036 - 92,045,190 (-)EnsemblChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366604520,189,540 - 20,227,199 (+)NCBIVero_WHO_p1.0
Ddx1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_004624865898,850 - 927,375 (-)NCBIHetGla_female_1.0hetGla2

Position Markers
RH124830  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381213,219,377 - 13,219,593UniSTSGRCm38
MGSCv371213,226,183 - 13,226,399UniSTSGRCm37
Celera1213,565,361 - 13,565,577UniSTS
Cytogenetic Map12A1.1UniSTS


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
11039525Tbbr2_mTrypanosoma brucei brucei response 2 (mouse)12122418579Mouse
1301393Dyscalc3_mdystrophic cardiac calcinosis 3 (mouse)Not determined12122418579Mouse
10402496Lmr22_mleishmaniasis resistance 22 (mouse)Not determined12122418579Mouse
1301143Skull17_mskull morphology 17 (mouse)Not determined12122418579Mouse
1357519Vtbt12_mvertebral trabecular bone trait 12 (mouse)Not determined12124662697Mouse
1301655Bmd12_mbone mineral density 12 (mouse)Not determined12124662697Mouse
4141296Femwf9_mfemur work to failure 9 (mouse)Not determined127920733Mouse
4141436Chldq7_mcholesterol and HDL QTL 7 (mouse)Not determined12127920733Mouse
12910983Pifs1_mpeptide-induced fatal syndrome 1 (mouse)12130433078Mouse
1301925Ath6_matherosclerosis 6 (mouse)Not determined12132758756Mouse
1301207Circp1_mcircadian photosensitivity 1 (mouse)Not determined12133430339Mouse
4141660Nbwa1_mNZB and NZW autoimmunity 1 (mouse)Not determined1234013434340302Mouse
26884410Bzwq15_mbi-zygomatic width QTL 15, 16 week (mouse)12365000029749999Mouse
4142234Tmc1m3_mTmc1 modifier 3 (mouse)Not determined12541844077031203Mouse
1301163Eae16_msusceptibility to experimental allergic encephalomyelitis 16 (mouse)Not determined12772315841723301Mouse
13208568Bmiq11_mbody mass index QTL 11 (mouse)12805000040049999Mouse
1301037Cd4ts5_mCD4 T cell subset 5 (mouse)Not determined12835244442352581Mouse
1301723Fcsa7_mfemoral cross-sectional area 7 (mouse)Not determined12949100443491112Mouse
27226753Femd7_mfemur midshaft diameter 7, 10 week (mouse)12955000084146774Mouse
12792982Fbmd4_mfemoral bone mineral density 4, females only (mouse)121004319424365136Mouse
14746972Manh72_mmandible shape 72 (mouse)121061528144615281Mouse
10401249Bglu15_mblood glucose level 15 (mouse)Not determined121062064244620809Mouse
13524843Ppiq8_mprepulse inhibition QTL 8 (mouse)121104319450945796Mouse
13207568Tcq14_mtotal cholesterol QTL 14 (mouse)121166000197176774Mouse
4141516slwr_mslowlearner (mouse)Not determined1239247546392614Mouse
13524839Ppiq10_mprepulse inhibition QTL 10 (mouse)121304319554945798Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:90
Count of miRNA genes:89
Interacting mature miRNAs:90
Transcripts:ENSMUST00000071103
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000071103   ⟹   ENSMUSP00000065987
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1213,266,974 - 13,299,214 (-)Ensembl
GRCm38.p6 Ensembl1213,216,973 - 13,249,213 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221028
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1213,275,162 - 13,279,380 (-)Ensembl
GRCm38.p6 Ensembl1213,225,161 - 13,229,379 (-)Ensembl
RefSeq Acc Id: ENSMUST00000221623   ⟹   ENSMUSP00000152513
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1213,287,733 - 13,299,164 (-)Ensembl
GRCm38.p6 Ensembl1213,237,732 - 13,249,163 (-)Ensembl
RefSeq Acc Id: NM_134040   ⟹   NP_598801
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391213,269,308 - 13,299,175 (-)NCBI
GRCm381213,219,307 - 13,249,174 (-)ENTREZGENE
MGSCv371213,226,113 - 13,255,980 (-)RGD
Celera1213,565,291 - 13,593,111 (-)RGD
cM Map12 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_598801   ⟸   NM_134040
- UniProtKB: Q91VR5 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000065987   ⟸   ENSMUST00000071103
RefSeq Acc Id: ENSMUSP00000152513   ⟸   ENSMUST00000221623
Protein Structures
Name Modeller Protein Id AA Range Protein Structure Video
AF-Q91VR5-F1-model_v2 AlphaFold Q91VR5 1-740 view protein structure  

Promoters
RGD ID:8677930
Promoter ID:EPDNEW_M16996
Type:initiation region
Name:Ddx1_1
Description:Mus musculus DEAD (Asp-Glu-Ala-Asp) box polypeptide 1 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381213,249,181 - 13,249,241EPDNEW
RGD ID:6822842
Promoter ID:MM_KWN:11180
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day4,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6
Transcripts:ENSMUST00000071103
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv361213,255,714 - 13,256,214 (-)MPROMDB

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2144727 AgrOrtholog
Ensembl Genes ENSMUSG00000037149 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000065987 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000152513 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000071103 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000221623 UniProtKB/TrEMBL
Gene3D-CATH 2.60.120.920 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.40.50.300 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro B30.2/SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  B30.2/SPRY_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  ConA-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  DEAD/DEAH_box_helicase_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_ATP-bd UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  RNA_helicase_DEAD_Q_motif UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:104721 UniProtKB/Swiss-Prot
MGD MGI:2144727 ENTREZGENE
NCBI Gene 104721 ENTREZGENE
Pfam DEAD UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Helicase_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Ddx1 PhenoGen
PROSITE B302_SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_ATP_BIND_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICASE_CTER UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Q_MOTIF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART DEXDc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  HELICc UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SPRY UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF49899 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF52540 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt A0A1Y7VM48_MOUSE UniProtKB/TrEMBL
  DDX1_MOUSE UniProtKB/Swiss-Prot
  Q3V1Z7_MOUSE UniProtKB/TrEMBL
  Q8BKG1_MOUSE UniProtKB/TrEMBL
  Q91VR5 ENTREZGENE
  Q922B8_MOUSE UniProtKB/TrEMBL
UniProt Secondary Q3TU41 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-04-07 Ddx1  DEAD box helicase 1  Ddx1  DEAD (Asp-Glu-Ala-Asp) box polypeptide 1  Symbol and/or name change 5135510 APPROVED