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Gene: GTF2A2 (general transcription factor IIA subunit 2) Homo sapiens
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Symbol: GTF2A2
Name: general transcription factor IIA subunit 2
Description: Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: general transcription factor IIA 2; general transcription factor iia, 2 (12kd subunit); general transcription factor IIA, 2, 12kDa; HsT18745; T18745; TF2A2; TFIIA; TFIIA gamma subunit; TFIIA p12 subunit; TFIIA-12; TFIIA-gamma; TFIIAS; transcription initiation factor IIA gamma chain; transcription initiation factor IIA subunit 2
Orthologs:
Mus musculus (house mouse) : Gtf2a2 (general transcription factor II A, 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gtf2a2 (general transcription factor 2A subunit 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gtf2a2 (general transcription factor IIA subunit 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GTF2A2 (general transcription factor IIA subunit 2)
Canis lupus familiaris (dog) : GTF2A2 (general transcription factor IIA subunit 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gtf2a2 (general transcription factor IIA subunit 2)
Sus scrofa (pig) : GTF2A2 (general transcription factor IIA subunit 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381559,638,062 - 59,657,541 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371559,930,261 - 59,949,737 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361557,718,358 - 57,736,987 (-)NCBINCBI36hg18NCBI36
Build 341557,718,357 - 57,736,985NCBI
Celera1536,818,236 - 36,837,689 (-)NCBI
Cytogenetic Map15q22.2NCBI
HuRef1536,752,262 - 36,771,682 (-)NCBIHuRef
CHM1_11560,048,219 - 60,067,698 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Nucleotide Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on GTF2A2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737167
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.