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Gene: GTF2A2 (general transcription factor IIA subunit 2) Homo sapiens
Symbol: GTF2A2
Name: general transcription factor IIA subunit 2
Description: Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and the general initiation factors TFIIA, TFIIB (MIM 189963), TFIID (MIM 313650), TFIIE (MIM 189962), TFIIF (MIM 189968), TFIIG/TFIIJ, and TFIIH (MIM 189972). The first step involves recognition of the TATA element by the TATA-binding subunit (TBP; MIM 600075) and may be regulated by TFIIA, a factor that interacts with both TBP and a TBP-associated factor (TAF; MIM 600475) in TFIID. TFIIA has 2 subunits (43 and 12 kD) in yeast and 3 subunits in higher eukaryotes. In HeLa extracts, it consists of a 35-kD alpha subunit and a 19-kD beta subunit encoded by the N- and C-terminal regions of GTF2A1 (MIM 600520), respectively, and a 12-kD gamma subunit encoded by GTF2A2 (DeJong et al., 1995 [PubMed 7724559]).[supplied by OMIM, Mar 2008]
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: general transcription factor IIA 2; general transcription factor iia, 2 (12kd subunit); general transcription factor IIA, 2, 12kDa; HsT18745; T18745; TF2A2; TFIIA; TFIIA gamma subunit; TFIIA p12 subunit; TFIIA-12; TFIIA-gamma; TFIIAS; transcription initiation factor IIA gamma chain; transcription initiation factor IIA subunit 2
Mus musculus (house mouse) : Gtf2a2 (general transcription factor II A, 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Gtf2a2 (general transcription factor 2A subunit 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Gtf2a2 (general transcription factor IIA subunit 2)
Pan paniscus (bonobo/pygmy chimpanzee) : GTF2A2 (general transcription factor IIA subunit 2)
Canis lupus familiaris (dog) : GTF2A2 (general transcription factor IIA subunit 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Gtf2a2 (general transcription factor IIA subunit 2)
Sus scrofa (pig) : GTF2A2 (general transcription factor IIA subunit 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381559,638,062 - 59,657,541 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371559,930,261 - 59,949,737 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361557,718,358 - 57,736,987 (-)NCBINCBI36hg18NCBI36
Build 341557,718,357 - 57,736,985NCBI
Celera1536,818,236 - 36,837,689 (-)NCBI
Cytogenetic Map15q22.2NCBI
HuRef1536,752,262 - 36,771,682 (-)NCBIHuRef
CHM1_11560,048,219 - 60,067,698 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated
RGD Disease Portals


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on GTF2A2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 737167
Created: 2004-02-06
Species: Homo sapiens
Last Modified: 2019-06-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.